abstract：:Patients with advanced prostate cancer (PCa) frequently develop skeletal metastases that are associated with fractures, disability, and increased mortality. Within the bone metastatic niche, mutual interactions between tumor cells and osteoblasts have been proposed as major contributors of osteotropism by PCa. Here, w...

journal_title：Trends in cancer

authors： Furesi G,Rauner M,Hofbauer LC

更新日期：2021-02-01 00:00:00

abstract：:Regular exercise reduces the risk of cancer. One potential mechanism for this efficacy is improved antitumor immunity. This is an important issue because evading immune destruction is a hallmark of cancer and immunotherapy is reshaping cancer treatment. Here we review recent developments reported by Wennerberg et al.,...

journal_title：Trends in cancer

authors： Fiuza-Luces C,Valenzuela PL,Castillo-García A,Lucia A

更新日期：2021-02-01 00:00:00

abstract：:Cancer of unknown primary (CUP) is a rare malignancy that presents with metastatic disease and no identifiable site of origin. Most patients have unfavorable features and attempts to treat based on tissue-of-origin identification have not yielded a survival advantage compared with empiric chemotherapy. Next-generation...

journal_title：Trends in cancer

authors： Kato S,Alsafar A,Walavalkar V,Hainsworth J,Kurzrock R

更新日期：2021-01-27 00:00:00

abstract：:Prediction of long-term outcomes from short-term measurements remains a fundamental challenge. Quantitative assessment of signaling dynamics, and the resulting transcriptomic and proteomic responses, has yielded fundamental insights into cellular outcomes. However, the utility of these measurements is limited by their...

journal_title：Trends in cancer

authors： Tsabar M,Lovitch SB,Jambhekar A,Lahav G

更新日期：2021-01-12 00:00:00

abstract：:The liver is one of the major metabolic organs in the body, susceptible to injury caused by various factors. In response to injury, sophisticated mechanisms are engaged to repair and regenerate the damaged liver, preventing its failure. When the damage is chronic, regeneration goes awry, impairing liver function and c...

journal_title：Trends in cancer

authors： Garrido A,Djouder N

更新日期：2021-01-01 00:00:00

abstract：:Traditionally, the efficacy of novel cancer therapies has been confirmed in patients failing regular treatment before being tested in early disease. Improved understanding of the mechanisms guiding therapeutic efficacy may challenge this dogma, suggesting novel therapies to move into early evaluation based on biologic...

journal_title：Trends in cancer

authors： Lønning PE

更新日期：2020-12-22 00:00:00

abstract：:Nuclear receptors are a family of transcription factors localized in cell nuclei, sensing specific ligands and fine-tuning a variety of cell physiological events. They have been intensively investigated in cancer biology. With their excellent properties of druggability and actionability, nuclear receptors have demonst...

journal_title：Trends in cancer

authors： Yang Z,Gimple RC,Zhou N,Zhao L,Gustafsson JÅ,Zhou S

更新日期：2020-12-16 00:00:00

abstract：:Fusobacterium nucleatum is an oral bacterium associated with colorectal cancer (CRC) proliferation, chemoresistance, inflammation, metastasis, and now DNA damage. While controlling F. nucleatum through antibiotics could reduce cancer severity, this article proposes additional strategies to block Fusobacterium-host int...

journal_title：Trends in cancer

authors： Slade DJ

更新日期：2020-12-09 00:00:00

abstract：:Mitochondria play an essential role in cellular metabolism, generation of reactive oxygen species (ROS), and the initiation of apoptosis. These properties enable mitochondria to be crucial integrators in the pathways of tumorigenesis. An open question is to what extent variation in the mitochondrial genome (mtDNA) con...

journal_title：Trends in cancer

authors： Tasdogan A,McFadden DG,Mishra P

更新日期：2020-12-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) determines the most lethal features of cancer, metastasis formation and chemoresistance, and therefore represents an attractive target in oncology. However, direct targeting of EMT effector molecules is, in most cases, pharmacologically challenging. Since emerging research ha...

journal_title：Trends in cancer

authors： Ramesh V,Brabletz T,Ceppi P

更新日期：2020-11-01 00:00:00

abstract：:Targeted therapy has become increasingly important in cancer therapy. For example, targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective treatment. PML is the core component of super-assembled structures called PML nuclear bodies (NBs). Although this nuclear megaDalton complex was ...

journal_title：Trends in cancer

authors： Li Y,Ma X,Wu W,Chen Z,Meng G

更新日期：2020-10-01 00:00:00

abstract：:In this commentary, we review the timeline of clinical trials and regulatory actions of approved immune checkpoint inhibitors for small cell lung cancer, discuss challenges faced by regulatory agencies, and highlight paradoxical lessons that emerge. Accelerated approvals may fail to expedite drugs to market in this se...

journal_title：Trends in cancer

authors： Gill J,Cetnar JP,Prasad V

更新日期：2020-09-01 00:00:00

abstract：:Prostate cancer affects one in every nine men in the USA and is the second leading cause of cancer-related death. The treatment landscape of advanced prostate cancer is changing rapidly. Multiple agents including abiraterone, enzalutamide, apalutamide, darolutamide, docetaxel, cabazitaxel, radium-223, and sipuleucel-T...

journal_title：Trends in cancer

authors： Swami U,McFarland TR,Nussenzveig R,Agarwal N

更新日期：2020-08-01 00:00:00

abstract：:Cancers develop within complex tissue environments consisting of diverse innate and adaptive immune cells, along with stromal cells, vascular networks, and many other cellular and noncellular components. The high heterogeneity within the tumor microenvironment (TME) remains a key obstacle in understanding and treating...

journal_title：Trends in cancer

authors： Duan Q,Zhang H,Zheng J,Zhang L

更新日期：2020-07-01 00:00:00

abstract：:Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consid...

journal_title：Trends in cancer

authors： McFarlane RJ,Wakeman JA

更新日期：2020-06-01 00:00:00

abstract：:Lactate dehydrogenase (LDH) accounts for the fermentative component of aerobic glycolysis, a near ubiquitous metabolic alteration in cancer. Recently, Oshima et al. developed a bioavailable LDH inhibitor that decreases tumor growth in mice and functions synergistically with mitochondrial respiration inhibitors. These ...

journal_title：Trends in cancer

authors： Quon E,Hart ML,Sullivan LB

更新日期：2020-05-01 00:00:00

abstract：:Tumor heterogeneity is a large conundrum in cancer medicine, making most therapeutic interventions palliative rather than curative. Here we discuss the implications of how molecularly targeted therapies in solid malignancies that promote limited cancer cell death may in fact make tumors more heterogeneous, increase ag...

journal_title：Trends in cancer

authors： Khatib S,Pomyen Y,Dang H,Wang XW

更新日期：2020-04-01 00:00:00

abstract：:Although immunotherapy has proved to be effective in a variety of cancer subtypes, the role of immune checkpoint inhibition in the treatment of prostate cancer remains unclear. Here we review results from the latest clinical trials and discuss data suggesting that certain genetic mutations may confer increased sensiti...

journal_title：Trends in cancer

authors： Nicholson LT,Fong L

更新日期：2020-03-01 00:00:00

abstract：:TP53 is the most frequently mutated gene in breast cancer, but its role in survival is confounded by different studies concluding that TP53 mutations are associated with negative, neutral, or positive outcomes. Closer examination showed that many studies were limited by factors such as imprecise methods to detect TP53...

journal_title：Trends in cancer

authors： Shahbandi A,Nguyen HD,Jackson JG

更新日期：2020-02-01 00:00:00

abstract：:Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome ...

journal_title：Trends in cancer

authors： Nizzero S,Shen H,Ferrari M,Corradetti B

更新日期：2020-01-01 00:00:00

abstract：:In a recent article, Bisogno et al. reported in a randomized trial that addition of metronomic maintenance therapy (MMT) with vinorelbine plus cyclophosphamide for children with rhabdomyosarcoma resulted in a significant increase in overall and event-free survival. Although the mechanism of action remains to be fully ...

journal_title：Trends in cancer

authors： André N,Corradini N,Shaked Y

更新日期：2019-12-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several protumourigenic functions. Several studies have recently reported that CAFs are more heterogenous and plastic than was previously thought. As such, there has been a shift...

journal_title：Trends in cancer

authors： Pereira BA,Vennin C,Papanicolaou M,Chambers CR,Herrmann D,Morton JP,Cox TR,Timpson P

更新日期：2019-11-01 00:00:00

abstract：:Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer. Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be opposed by deubiquitinases (DUBs), which have emerged as promising drug targets. Apart from protein localization and activity, ubiquitylati...

journal_title：Trends in cancer

authors： Mennerich D,Kubaichuk K,Kietzmann T

更新日期：2019-10-01 00:00:00

abstract：:GLI-similar 1-3 (GLIS1-3), a subfamily of Krüppel-like zinc finger transcription factors, function as key regulators of several biological processes important to oncogenesis, including control of cell proliferation, differentiation, self-renewal, and epithelial-mesenchymal transition. This review provides a short over...

journal_title：Trends in cancer

authors： Jetten AM

更新日期：2019-09-01 00:00:00

abstract：:The regulation of immune responses by tumors is central to their survival. By diminishing the production of interferon (IFN) and other inflammatory mediators, tumors enhance immune evasion. Responses initiated by nucleic acid sensors and triggered by dysregulated RNA transcription and cytoplasmic DNA undergo down-modu...

journal_title：Trends in cancer

authors： Herbert A

更新日期：2019-05-01 00:00:00

abstract：:Dysregulation of the PI3K/PTEN pathway is a frequent event in cancer, and PIK3CA and PTEN are the most commonly mutated genes after TP53. PIK3R1 is the predominant regulatory isoform of PI3K. PIK3R2 is an ubiquitous isoform that has been so far overlooked, but data from The Cancer Genome Atlas shows that increased exp...

journal_title：Trends in cancer

authors： Vallejo-Díaz J,Chagoyen M,Olazabal-Morán M,González-García A,Carrera AC

更新日期：2019-04-01 00:00:00

abstract：:Preclinical and clinical data emerging over the past year demonstrate that cancer cells suppress the cytotoxic functions of natural killer cells by a variety of mechanisms. These findings reveal a new arsenal of actionable therapeutic targets to drive clinically relevant immune responses against cancer. ...

journal_title：Trends in cancer

authors： Wennerberg E,Galluzzi L

更新日期：2019-03-01 00:00:00

abstract：:Alternative splicing (AS) has many important roles in the pathogenesis of leukemia. Recent papers suggest that one of its key aspects is exclusion of 3'-terminal exons in favor of premature termination using intronic polyadenylation signals. This process generates leukemia suppressor isoforms with truncated C termini ...

journal_title：Trends in cancer

authors： Asnani M,Thomas-Tikhonenko A

更新日期：2018-12-01 00:00:00

abstract：:Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection of immunogenic cancers and for the success of T cell-based immuno...

journal_title：Trends in cancer

authors： Böttcher JP,Reis e Sousa C

更新日期：2018-11-01 00:00:00

abstract：:For millenia, plants have been a major source of medications against human and animal diseases. In the case of anticancer agents, a significant number of current agents can trace their source back to nominally plant secondary metabolites, with examples being taxol, vinca alkaloids, camptothecin (CPT), and their modifi...

journal_title：Trends in cancer

authors： Newman DJ

更新日期：2018-10-01 00:00:00

abstract：:Given the implication of aberrant RAS-extracellular signal-regulated kinase (ERK) signaling in the development of a large number of tumor types, this route is under intense scrutiny to identify new anticancer drugs. Most avenues in that direction have been primarily focused on the inhibition of the catalytic activity ...

journal_title：Trends in cancer

authors： García-Gómez R,Bustelo XR,Crespo P

更新日期：2018-09-01 00:00:00

abstract：:Even though we have known for over 250 years that cancers spread to regional lymph nodes (LNs) and distant organs, the fundamental question of which anatomical routes are taken by tumor cells has remained a mystery. Two recently published papers in Science, by Pereira et al. and Brown et al., directly address this imp...

journal_title：Trends in cancer

authors： Achen MG,Stacker SA

更新日期：2018-08-01 00:00:00

abstract：:The rapidly evolving field of cancer immunotherapy recently saw the approval of several new therapeutic antibodies. Several cell therapies, for example, chimeric antigen receptor-expressing T cells (CAR-T), are currently in clinical trials for a variety of cancers and other diseases. However, approaches to monitor cha...

journal_title：Trends in cancer

authors： Wei W,Jiang D,Ehlerding EB,Luo Q,Cai W

更新日期：2018-05-01 00:00:00

abstract：:Obesity has been associated with increased severity of diagnoses for several types of cancer, and recent evidence suggests that the mechanism by which obese tissues contribute to cancer progression involves the extracellular matrix (ECM). Understanding the physicochemical differences between lean and obese ECM, and ho...

journal_title：Trends in cancer

authors： Druso JE,Fischbach C

更新日期：2018-04-01 00:00:00

abstract：:Ibrutinib resistance, as a result of coordinated rewiring of signaling networks and enforced tumor microenvironment (TME)-lymphoma interactions, drives unrestrained proliferation and disease progression. To combat resistance mechanisms, we must identify the compensatory resistance pathways and the central modulators o...

journal_title：Trends in cancer

authors： Shah B,Zhao X,Silva AS,Shain KH,Tao J

更新日期：2018-03-01 00:00:00

abstract：:The pace of genomic and immunological breakthroughs in oncology is accelerating, making it likely that large randomized trials will increasingly become outdated before their completion. Traditional clinical research/practice paradigms must adapt to the reality unveiled by genomics, especially the need for customized d...

journal_title：Trends in cancer

authors： Subbiah V,Kurzrock R

更新日期：2018-02-01 00:00:00

abstract：:Curative therapy for cancer patients with advanced-stage disease remains elusive. While rare outlier responses to anticancer therapies exist, barriers limit our understanding of the molecular and genetic basis of such profound, life-altering responses. Here, we describe how phenotype-to-genotype studies are elucidatin...

journal_title：Trends in cancer

authors： Jonsson P,Taylor BS

更新日期：2018-01-01 00:00:00

abstract：:The extremely high cancer incidence associated with patients suffering from a rare human genetic disease, Fanconi anemia (FA), demonstrates the importance of FA genes. Over the course of human tumor development, FA genes perform critical tumor-suppression roles. In doing so, FA provides researchers with a unique genet...

journal_title：Trends in cancer

authors： Nepal M,Che R,Zhang J,Ma C,Fei P

更新日期：2017-12-01 00:00:00

abstract：:Lysophosphatidate (LPA) is emerging as a potent mediator of cancer progression in the tumor microenvironment. Strategies for targeting LPA signaling have recently entered clinical trials for fibrosis. These therapies have potential to improve the efficacies of existing chemotherapies and radiotherapy by attenuating ch...

journal_title：Trends in cancer

authors： Benesch MGK,Yang Z,Tang X,Meng G,Brindley DN

更新日期：2017-11-01 00:00:00

abstract：:Cancer immunotherapy has recently emerged as a forefront strategy to fight cancer. Key players in antitumor responses are CD8+ cytolytic T lymphocytes (CTLs) that can detect tumor cells that carry antigens, in other words, small peptides bound to surface major histocompatibility complex (MHC) class I molecules. The su...

journal_title：Trends in cancer

authors： Vigneron N,Abi Habib J,Van den Eynde BJ

更新日期：2017-10-01 00:00:00