Abstract：
:Cancer of unknown primary (CUP) is a rare malignancy that presents with metastatic disease and no identifiable site of origin. Most patients have unfavorable features and attempts to treat based on tissue-of-origin identification have not yielded a survival advantage compared with empiric chemotherapy. Next-generation sequencing has revealed genomic alterations that can be targeted in selected cases, suggesting that CUP represents a unique malignancy in which the genomic aberrations may be integral to the diagnosis. Recent trials focusing on tailored combination therapy matched to the genomic alterations in each cancer are providing new avenues of clinical investigation. Here, we discuss recent findings on molecular aberrations in CUP and how the genomic and immune landscape can be leveraged to optimize therapy.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Kato S,Alsafar A,Walavalkar V,Hainsworth J,Kurzrock Rdoi
10.1016/j.trecan.2020.11.002subject
Has Abstractpub_date
2021-01-27 00:00:00eissn
2405-8033issn
2405-8025pii
S2405-8033(20)30301-0pub_type
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