Abstract：
:Targeted therapy has become increasingly important in cancer therapy. For example, targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective treatment. PML is the core component of super-assembled structures called PML nuclear bodies (NBs). Although this nuclear megaDalton complex was first observed in the 1960s, the mechanism of its assembly remains poorly understood. We review recent breakthroughs in the PML field ranging from a revised assembly mechanism to PML-driven genome organization and carcinogenesis. In addition, we highlight that oncogenic oligomerization might also represent a promising target in the treatment of leukemias and solid tumors.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Li Y,Ma X,Wu W,Chen Z,Meng Gdoi
10.1016/j.trecan.2020.05.005subject
Has Abstractpub_date
2020-10-01 00:00:00pages
889-906issue
10eissn
2405-8033issn
2405-8025pii
S2405-8033(20)30160-6journal_volume
6pub_type
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