Abstract：
:Pancreatic ductal adenocarcinoma (PDAC) represents a major global health problem that causes over 200000 deaths each year worldwide. The disease is highly resistant to cytotoxic and targeted therapies and the average survival is less than 12 months. This situation prompted Alessandro Carugo and Giulio Draetta to develop a novel genetic mouse system, termed Patient-Based In Vivo Lethality to Optimize Treatment (PILOT), to perform functional RNAi-based in vivo screens to uncover and target PDAC drivers. In a forward genetic screen focused on epigenetic modifiers, a WDR5-Myc axis that regulates the DNA replication checkpoint was identified and exploited in vivo for therapeutic intervention.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Schneider G,Saur Ddoi
10.1016/j.trecan.2016.07.002subject
Has Abstractpub_date
2016-08-01 00:00:00pages
391-392issue
8eissn
2405-8033issn
2405-8025pii
S2405-8033(16)30081-4journal_volume
2pub_type
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