Abstract：
:Lactate dehydrogenase (LDH) accounts for the fermentative component of aerobic glycolysis, a near ubiquitous metabolic alteration in cancer. Recently, Oshima et al. developed a bioavailable LDH inhibitor that decreases tumor growth in mice and functions synergistically with mitochondrial respiration inhibitors. These findings suggest a cooperative mechanism of action that targets redox homeostasis.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Quon E,Hart ML,Sullivan LBdoi
10.1016/j.trecan.2020.02.012subject
Has Abstractpub_date
2020-05-01 00:00:00pages
359-361issue
5eissn
2405-8033issn
2405-8025pii
S2405-8033(20)30073-Xjournal_volume
6pub_type
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