Abstract：
:The movement toward precision medicine with targeted therapeutics for cancer treatment has been hindered by both innate and acquired resistance. Understanding the molecular wiring and plasticity of oncogenic signaling networks is essential to the development of therapeutic strategies to avoid or overcome resistance. The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) represents a highly integrated signaling node that is dysregulated in the majority of human cancers. Several studies have revealed that sustained mTORC1 inhibition is essential to avoid resistance to targeted therapeutics against the driving oncogenic pathway in a given cancer. Here we discuss the role of mTORC1 in dictating the response of tumors to targeted therapeutics and review recent examples from lung cancer, breast cancer, and melanoma.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Ilagan E,Manning BDdoi
10.1016/j.trecan.2016.03.008subject
Has Abstractpub_date
2016-05-01 00:00:00pages
241-251issue
5eissn
2405-8033issn
2405-8025journal_volume
2pub_type
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