Abstract：
:The tumor microenvironment has an essential role in defining tumor malignancy, since it can either promote or prevent tumor initiation and subsequent progression and metastatic dissemination. Recent studies demonstrate that highly aggressive cancer cells display a high degree of metabolic plasticity paralleled by the acquisition of stemness and chemoresistant properties. In addition, cancer-associated fibroblasts, endothelial cells, and immune cells have an important role in shaping the metabolic behavior of cancer cells. This review discusses the current knowledge of metabolic reprogramming in cancer, the tumor-stroma metabolic crosstalk, and the available compounds that may be used to effectively target the tumor-stroma metabolic symbiosis.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Morandi A,Giannoni E,Chiarugi Pdoi
10.1016/j.trecan.2016.11.001subject
Has Abstractpub_date
2016-12-01 00:00:00pages
736-746issue
12eissn
2405-8033issn
2405-8025pii
S2405-8033(16)30164-9journal_volume
2pub_type
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