Abstract：
:Alternative splicing (AS) has many important roles in the pathogenesis of leukemia. Recent papers suggest that one of its key aspects is exclusion of 3'-terminal exons in favor of premature termination using intronic polyadenylation signals. This process generates leukemia suppressor isoforms with truncated C termini and acting in loss-of-function or dominant-negative manners.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Asnani M,Thomas-Tikhonenko Adoi
10.1016/j.trecan.2018.10.005subject
Has Abstractpub_date
2018-12-01 00:00:00pages
796-798issue
12eissn
2405-8033issn
2405-8025pii
S2405-8033(18)30223-1journal_volume
4pub_type
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