Abstract：
:Given the implication of aberrant RAS-extracellular signal-regulated kinase (ERK) signaling in the development of a large number of tumor types, this route is under intense scrutiny to identify new anticancer drugs. Most avenues in that direction have been primarily focused on the inhibition of the catalytic activity of the kinases that participate in this pathway. Although promising, the efficacy of these therapies is short lived due to undesired toxicity and/or drug resistance problems. As an alternative path, new efforts are now being devoted to the targeting of protein-protein interactions (PPIs) involved in the flow of RAS-ERK signals. Many of these efforts have shown promising results in preclinical models. In this review, we summarize recent progress made in this area.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
García-Gómez R,Bustelo XR,Crespo Pdoi
10.1016/j.trecan.2018.07.002subject
Has Abstractpub_date
2018-09-01 00:00:00pages
616-633issue
9eissn
2405-8033issn
2405-8025pii
S2405-8033(18)30155-9journal_volume
4pub_type
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