Abstract:
:Cadherins are key components in tissue morphogenesis and architecture, contributing to the establishment of cohesive cell adhesion. Reduced cellular adhesiveness as a result of cadherin dysfunction is a defining feature of cancer. During tumor development and progression, major changes in the glycan repertoire of cancer cells take place, affecting the stability, trafficking, and cell-adhesion properties of cadherins. Importantly, the different glycoforms of cadherins are promising biomarkers, with potential clinical application to improve the management of patients, and constitute targets for the development of new therapies. This review discusses the most recent insights on the impact of glycan structure on the regulation of cadherin function in cancer, and provides a perspective on how cadherin glycans constitute tumor biomarkers and potential therapeutic targets.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Carvalho S,Reis CA,Pinho SSdoi
10.1016/j.trecan.2016.08.003subject
Has Abstractpub_date
2016-09-01 00:00:00pages
519-531issue
9eissn
2405-8033issn
2405-8025pii
S2405-8033(16)30106-6journal_volume
2pub_type
杂志文章,评审相关文献
Trends in Cancer文献大全abstract::Epithelial-to-mesenchymal transition (EMT) determines the most lethal features of cancer, metastasis formation and chemoresistance, and therefore represents an attractive target in oncology. However, direct targeting of EMT effector molecules is, in most cases, pharmacologically challenging. Since emerging research ha...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2020.06.005
更新日期:2020-11-01 00:00:00
abstract::Cancer of unknown primary (CUP) is a rare malignancy that presents with metastatic disease and no identifiable site of origin. Most patients have unfavorable features and attempts to treat based on tissue-of-origin identification have not yielded a survival advantage compared with empiric chemotherapy. Next-generation...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2020.11.002
更新日期:2021-01-27 00:00:00
abstract::The extremely high cancer incidence associated with patients suffering from a rare human genetic disease, Fanconi anemia (FA), demonstrates the importance of FA genes. Over the course of human tumor development, FA genes perform critical tumor-suppression roles. In doing so, FA provides researchers with a unique genet...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2017.10.005
更新日期:2017-12-01 00:00:00
abstract::The molecular basis for the clinical heterogeneity observed in patients with malignant rhabdoid tumors is unknown. Recently, two reports revealed molecular inter-tumor heterogeneity in teratoid/rhabdoid tumors (ATRTs) and extra-cranial MRTs (ecMRTs) using genomic, transcriptomic and epigenomic profiling. Distinct mole...
journal_title:Trends in cancer
pub_type: 评论,杂志文章
doi:10.1016/j.trecan.2016.04.003
更新日期:2016-05-01 00:00:00
abstract::Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consid...
journal_title:Trends in cancer
pub_type: 杂志文章
doi:10.1016/j.trecan.2020.02.014
更新日期:2020-06-01 00:00:00
abstract::The repurposing of existing non-cancer drugs is a potential source of new treatment options for cancer patients with high unmet medical needs. While scientific research is progressing rapidly in the field of drug repurposing, the implementation of drug repurposing still faces important financial and regulatory hurdles...
journal_title:Trends in cancer
pub_type: 杂志文章
doi:10.1016/j.trecan.2017.06.007
更新日期:2017-08-01 00:00:00
abstract::The Abelson (ABL) tyrosine kinases were identified as drivers of leukemia in mice and humans. Emerging data has shown a role for the ABL family kinases, ABL1 and ABL2, in the progression of several solid tumors. This review will focus on recent reports of the involvement of the ABL kinases in tumor progression using m...
journal_title:Trends in cancer
pub_type: 杂志文章
doi:10.1016/j.trecan.2015.07.004
更新日期:2015-10-01 00:00:00
abstract::For millenia, plants have been a major source of medications against human and animal diseases. In the case of anticancer agents, a significant number of current agents can trace their source back to nominally plant secondary metabolites, with examples being taxol, vinca alkaloids, camptothecin (CPT), and their modifi...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2018.08.002
更新日期:2018-10-01 00:00:00
abstract::The tumor microenvironment has an essential role in defining tumor malignancy, since it can either promote or prevent tumor initiation and subsequent progression and metastatic dissemination. Recent studies demonstrate that highly aggressive cancer cells display a high degree of metabolic plasticity paralleled by the ...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2016.11.001
更新日期:2016-12-01 00:00:00
abstract::Cancers develop within complex tissue environments consisting of diverse innate and adaptive immune cells, along with stromal cells, vascular networks, and many other cellular and noncellular components. The high heterogeneity within the tumor microenvironment (TME) remains a key obstacle in understanding and treating...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2020.02.022
更新日期:2020-07-01 00:00:00
abstract::Ibrutinib resistance, as a result of coordinated rewiring of signaling networks and enforced tumor microenvironment (TME)-lymphoma interactions, drives unrestrained proliferation and disease progression. To combat resistance mechanisms, we must identify the compensatory resistance pathways and the central modulators o...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2018.01.004
更新日期:2018-03-01 00:00:00
abstract::Lysophosphatidate (LPA) is emerging as a potent mediator of cancer progression in the tumor microenvironment. Strategies for targeting LPA signaling have recently entered clinical trials for fibrosis. These therapies have potential to improve the efficacies of existing chemotherapies and radiotherapy by attenuating ch...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2017.09.004
更新日期:2017-11-01 00:00:00
abstract::Fusobacterium nucleatum is an oral bacterium associated with colorectal cancer (CRC) proliferation, chemoresistance, inflammation, metastasis, and now DNA damage. While controlling F. nucleatum through antibiotics could reduce cancer severity, this article proposes additional strategies to block Fusobacterium-host int...
journal_title:Trends in cancer
pub_type: 杂志文章
doi:10.1016/j.trecan.2020.11.006
更新日期:2020-12-09 00:00:00
abstract::Nuclear receptors are a family of transcription factors localized in cell nuclei, sensing specific ligands and fine-tuning a variety of cell physiological events. They have been intensively investigated in cancer biology. With their excellent properties of druggability and actionability, nuclear receptors have demonst...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2020.11.007
更新日期:2020-12-16 00:00:00
abstract::Even though we have known for over 250 years that cancers spread to regional lymph nodes (LNs) and distant organs, the fundamental question of which anatomical routes are taken by tumor cells has remained a mystery. Two recently published papers in Science, by Pereira et al. and Brown et al., directly address this imp...
journal_title:Trends in cancer
pub_type: 评论,杂志文章
doi:10.1016/j.trecan.2018.05.007
更新日期:2018-08-01 00:00:00
abstract::The regulation of immune responses by tumors is central to their survival. By diminishing the production of interferon (IFN) and other inflammatory mediators, tumors enhance immune evasion. Responses initiated by nucleic acid sensors and triggered by dysregulated RNA transcription and cytoplasmic DNA undergo down-modu...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2019.03.004
更新日期:2019-05-01 00:00:00
abstract::Alternative lengthening of telomeres (ALT) is an enigmatic process that allows certain cancers to maintain telomeres in the absence of telomerase. ALT cancers are frequently defective for ATRX/DAXX, a chaperone complex that deposits histone variant H3.3 at telomeres. We propose that mutations in alpha thalassemia-ment...
journal_title:Trends in cancer
pub_type: 杂志文章
doi:10.1016/j.trecan.2016.02.003
更新日期:2016-03-01 00:00:00
abstract::Cancer immunotherapy has recently emerged as a forefront strategy to fight cancer. Key players in antitumor responses are CD8+ cytolytic T lymphocytes (CTLs) that can detect tumor cells that carry antigens, in other words, small peptides bound to surface major histocompatibility complex (MHC) class I molecules. The su...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2017.07.007
更新日期:2017-10-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) represents a major global health problem that causes over 200000 deaths each year worldwide. The disease is highly resistant to cytotoxic and targeted therapies and the average survival is less than 12 months. This situation prompted Alessandro Carugo and Giulio Draetta to devel...
journal_title:Trends in cancer
pub_type: 评论,杂志文章
doi:10.1016/j.trecan.2016.07.002
更新日期:2016-08-01 00:00:00
abstract::Neutrophil extracellular traps (NETs) have emerged as significant contributors to cancer-associated pathologies such as metastasis, thrombosis, and organ dysfunction in preclinical models. We review recent discoveries of the involvement of NETs in human cancers and suggest tumor-induced NET formation as an interesting...
journal_title:Trends in cancer
pub_type: 杂志文章
doi:10.1016/j.trecan.2016.10.012
更新日期:2016-11-01 00:00:00
abstract::In a recent article, Bisogno et al. reported in a randomized trial that addition of metronomic maintenance therapy (MMT) with vinorelbine plus cyclophosphamide for children with rhabdomyosarcoma resulted in a significant increase in overall and event-free survival. Although the mechanism of action remains to be fully ...
journal_title:Trends in cancer
pub_type: 评论,杂志文章
doi:10.1016/j.trecan.2019.10.004
更新日期:2019-12-01 00:00:00
abstract::Targeted therapy has become increasingly important in cancer therapy. For example, targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective treatment. PML is the core component of super-assembled structures called PML nuclear bodies (NBs). Although this nuclear megaDalton complex was ...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2020.05.005
更新日期:2020-10-01 00:00:00
abstract::The liver is one of the major metabolic organs in the body, susceptible to injury caused by various factors. In response to injury, sophisticated mechanisms are engaged to repair and regenerate the damaged liver, preventing its failure. When the damage is chronic, regeneration goes awry, impairing liver function and c...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2020.08.005
更新日期:2021-01-01 00:00:00
abstract::Regular exercise reduces the risk of cancer. One potential mechanism for this efficacy is improved antitumor immunity. This is an important issue because evading immune destruction is a hallmark of cancer and immunotherapy is reshaping cancer treatment. Here we review recent developments reported by Wennerberg et al.,...
journal_title:Trends in cancer
pub_type: 杂志文章
doi:10.1016/j.trecan.2020.12.003
更新日期:2021-02-01 00:00:00
abstract::Preclinical and clinical data emerging over the past year demonstrate that cancer cells suppress the cytotoxic functions of natural killer cells by a variety of mechanisms. These findings reveal a new arsenal of actionable therapeutic targets to drive clinically relevant immune responses against cancer. ...
journal_title:Trends in cancer
pub_type: 信件
doi:10.1016/j.trecan.2018.12.005
更新日期:2019-03-01 00:00:00
abstract::TP53 is the most frequently mutated gene in breast cancer, but its role in survival is confounded by different studies concluding that TP53 mutations are associated with negative, neutral, or positive outcomes. Closer examination showed that many studies were limited by factors such as imprecise methods to detect TP53...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2020.01.007
更新日期:2020-02-01 00:00:00
abstract::Immuno-oncology has gained momentum thanks to the success of strategies aimed at enhancing immune-mediated antitumor response. The field of immunotherapeutic transport oncophysics investigates the physical processes that drive cancer immunotherapies. This review discusses three main aspects that determine the outcome ...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2019.11.008
更新日期:2020-01-01 00:00:00
abstract::GLI-similar 1-3 (GLIS1-3), a subfamily of Krüppel-like zinc finger transcription factors, function as key regulators of several biological processes important to oncogenesis, including control of cell proliferation, differentiation, self-renewal, and epithelial-mesenchymal transition. This review provides a short over...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2019.07.005
更新日期:2019-09-01 00:00:00
abstract::Patients with advanced prostate cancer (PCa) frequently develop skeletal metastases that are associated with fractures, disability, and increased mortality. Within the bone metastatic niche, mutual interactions between tumor cells and osteoblasts have been proposed as major contributors of osteotropism by PCa. Here, w...
journal_title:Trends in cancer
pub_type: 杂志文章,评审
doi:10.1016/j.trecan.2020.09.006
更新日期:2021-02-01 00:00:00
abstract::Traditionally, the efficacy of novel cancer therapies has been confirmed in patients failing regular treatment before being tested in early disease. Improved understanding of the mechanisms guiding therapeutic efficacy may challenge this dogma, suggesting novel therapies to move into early evaluation based on biologic...
journal_title:Trends in cancer
pub_type: 杂志文章
doi:10.1016/j.trecan.2020.11.010
更新日期:2020-12-22 00:00:00