Abstract：
:The extremely high cancer incidence associated with patients suffering from a rare human genetic disease, Fanconi anemia (FA), demonstrates the importance of FA genes. Over the course of human tumor development, FA genes perform critical tumor-suppression roles. In doing so, FA provides researchers with a unique genetic model system to study cancer etiology. Here, we review how aberrant function of the 22 FA genes and their signaling network contributes to malignancy. From this perspective, we will also discuss how the knowledge discovered from FA research serves basic and translational cancer research.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Nepal M,Che R,Zhang J,Ma C,Fei Pdoi
10.1016/j.trecan.2017.10.005subject
Has Abstractpub_date
2017-12-01 00:00:00pages
840-856issue
12eissn
2405-8033issn
2405-8025pii
S2405-8033(17)30199-1journal_volume
3pub_type
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