Abstract：
:The rapidly evolving field of cancer immunotherapy recently saw the approval of several new therapeutic antibodies. Several cell therapies, for example, chimeric antigen receptor-expressing T cells (CAR-T), are currently in clinical trials for a variety of cancers and other diseases. However, approaches to monitor changes in the immune status of tumors or to predict therapeutic responses are limited. Monitoring lymphocytes from whole blood or biopsies does not provide dynamic and spatial information about T cells in heterogeneous tumors. Positron emission tomography (PET) imaging using probes specific for T cells can noninvasively monitor systemic and intratumoral immune alterations during experimental therapies and may have an important and expanding value in the clinic.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Wei W,Jiang D,Ehlerding EB,Luo Q,Cai Wdoi
10.1016/j.trecan.2018.03.009subject
Has Abstractpub_date
2018-05-01 00:00:00pages
359-373issue
5eissn
2405-8033issn
2405-8025pii
S2405-8033(18)30080-3journal_volume
4pub_type
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