Abstract：
:Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
McFarlane RJ,Wakeman JAdoi
10.1016/j.trecan.2020.02.014subject
Has Abstractpub_date
2020-06-01 00:00:00pages
450-453issue
6eissn
2405-8033issn
2405-8025pii
S2405-8033(20)30075-3journal_volume
6pub_type
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