Abstract：
:Mitochondria play an essential role in cellular metabolism, generation of reactive oxygen species (ROS), and the initiation of apoptosis. These properties enable mitochondria to be crucial integrators in the pathways of tumorigenesis. An open question is to what extent variation in the mitochondrial genome (mtDNA) contributes to the biological heterogeneity observed in human tumors. In this review, we summarize our current understanding of the role of mtDNA genetics in relation to human cancers.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Tasdogan A,McFadden DG,Mishra Pdoi
10.1016/j.trecan.2020.08.004subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1044-1058issue
12eissn
2405-8033issn
2405-8025pii
S2405-8033(20)30236-3journal_volume
6pub_type
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