Abstract:
:Most hepatocellular carcinoma (HCC) patients have complications, including cirrhosis and malnutrition. The efficacy of dietary supplementation with oral branched-chain amino acids (BCAAs) in HCC patients undergoing interventions has not been confirmed. Relevant publications on the efficacy and safety of oral BCAA supplementation for HCC patients undergoing anti-HCC interventions through September, 2014 were searched for identification in the PubMed, Embase, Web of Science, and the Cochrane Library databases. The pooled risk ratio (RR) and standardized mean difference (SMD) were used to assess the supplementation effects. A total of 11 eligible studies (974 patients in total) were evaluated and included in our analysis. Oral BCAA supplementation helped to maintain liver reserve with higher serum albumin (SMD = 0.234, 95% CI: 0.033-0.435, P = 0.022), and lower rates of ascites (RR = 0.545, 95% CI: 0.316-0.938, P = 0.029) and edema (RR = 0.494, 95% CI: 0.257-0.952, P = 0.035) than in the control group. BCAA supplementation seemed to be effective in improving mortality, especially in Child-Pugh class B patients, but the efficacy was not confirmed. Apparent effects were not found in improving HCC recurrence, total bilirubin, ALT, or AST. BCAA supplementation was relatively safe without serious adverse events. BCAA supplementation may be clinically applied in improving liver functional reserve for HCC patients and further improving the quality of life.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Chen L,Chen Y,Wang X,Li H,Zhang H,Gong J,Shen S,Yin W,Hu Hdoi
10.1186/s12937-015-0056-6subject
Has Abstractpub_date
2015-07-09 00:00:00pages
67issn
1475-2891pii
10.1186/s12937-015-0056-6journal_volume
14pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:Measuring the effects of the acute intake of natural products on human biomarker concentrations, such as those related to oxidation and inflammation, can be an advantageous strategy for early clinical research on an ingredient or product. METHODS:31 total healthy subjects were randomized in a double-blinded...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-67
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:Antenatal vitamin D status may be associated with the risk of adverse pregnancy and neonatal outcomes; however, the benefits of vitamin D supplementation during pregnancy remain unknown. METHODS:We conducted a double-blind placebo-controlled randomized trial to evaluate the effect of high-dose prenatal 3rd ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-47
更新日期:2013-04-12 00:00:00
abstract:BACKGROUND:Data on the use of lipid emulsions containing fish-oil (FO) derived n-3 polyunsaturated fatty acids (n-3 PUFAs) in addition to medium- and long-chain triglycerides (MCT/LCT) for long-term home parenteral nutrition (HPN) are limited. This study aimed to compare HPN regimens containing either MCT/LCT/FO-derive...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-018-0419-x
更新日期:2018-11-30 00:00:00
abstract:BACKGROUND:Fish consumption and intake of omega-3 fatty acids from fish are associated with a lower risk of cardiovascular disease. However, a prospective study from northern Sweden showed that high consumption of fish is associated with an increased risk of stroke in men, but not in women. The current study aimed to d...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-101
更新日期:2012-12-04 00:00:00
abstract:BACKGROUND:Constipation is a common occurrence in formula-fed infants. The aim of this preliminary study was to evaluate the impact of a formula with high levels of lactose and magnesium, in compliance with the official regulations, on stool water content, as well as a parental assessment of constipation. MATERIALS AN...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-55
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:The extent to which psychosocial and diet behavior factors affect dietary self-report remains unclear. We examine the contribution of these factors to measurement error of self-report. METHODS:In 450 postmenopausal women in the Women's Health Initiative Observational Study doubly labeled water and urinary n...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-63
更新日期:2013-05-16 00:00:00
abstract:BACKGROUND:Among natural compounds, present in every day diet, flavonoids have shown beneficial effect in prevention of cardiovascular diseases that can be attributed, at least partially to the described antiaggregatory activity i.e. antiplatelet effects of flavonoids. Due to the ever increasing pharmacological interes...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-73
更新日期:2011-07-11 00:00:00
abstract:BACKGROUND AND AIM:Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect of fenugreek intake o...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/1475-2891-13-7
更新日期:2014-01-18 00:00:00
abstract:BACKGROUND:Several studies have shown that cocoa and cocoa-containing foods have the potential to lower blood pressure and improve endothelial function. Most of the studies reporting the beneficial effects of dark chocolate on blood pressure have been short (≤ 4 weeks). The aim of the present 8-wks (weeks) study was to...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0075-3
更新日期:2015-08-22 00:00:00
abstract:BACKGROUND:To assess the nutrition knowledge of physicians on the basic effects of diet on blood lipids and lipoproteins. METHODS:Anonymous mailed dietary knowledge surveys to 6000 randomly selected physicians in the United States licensed in either Internal Medicine or Cardiology. RESULTS:Response rate: 16% (n = 639...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-2-19
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hor...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-12-137
更新日期:2013-10-11 00:00:00
abstract:BACKGROUND:Epidemiological studies regarding the association between dietary fiber intake and ovarian cancer risk are still inconsistent. We aimed to review the available evidence and conduct a dose-response meta-analysis to investigate the relationship between dietary fiber intake and ovarian cancer risk. METHODS:Rel...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12937-018-0407-1
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:Intra-articular hyaluronic acid represents a substantive addition to the therapeutic armamentarium in knee osteoarthritis. We examined the effect of dietary supplementation with a natural extract of chicken combs with a high content of hyaluronic acid (60%) (Hyal-Joint) (active test product, AP) on pain and ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-7-3
更新日期:2008-01-21 00:00:00
abstract:BACKGROUND:To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada. METHODS:A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-70
更新日期:2013-06-02 00:00:00
abstract:BACKGROUND:Information regarding dietary patterns associated with prediabetes in the Chinese population is lacking. The objective of the present study was to explore the association between major dietary patterns and the risk of prediabetes in a middle-aged Chinese population. METHODS:A total of 1761 participants (age...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00593-1
更新日期:2020-07-30 00:00:00
abstract:BACKGROUND:Decreased ability of muscles to respond to anabolic stimuli is part of the underlying mechanism for muscle loss with aging. Previous studies suggest that substantial amounts of essential amino acids (EAA), whey protein and leucine are beneficial for stimulation of acute muscle protein synthesis in older adul...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-9
更新日期:2014-01-22 00:00:00
abstract::Several observational studies suggest an association between coffee intake and hip fracture risk. However, the results among them are inconsistent. We aimed to evaluate the association between coffee consumption and risk of hip fracture by performing a meta-analysis of prospective cohort studies. PubMed, Embase, and W...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12937-015-0025-0
更新日期:2015-04-18 00:00:00
abstract:BACKGROUND:We have recently reported that short-term (21-day) dietary modification in accordance with a stringent vegan diet (i.e., a Daniel Fast) lowers blood lipids as well as biomarkers of oxidative stress. However, this work only involved measurements obtained in a fasted state. In the present study, we determined ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-16
更新日期:2012-03-21 00:00:00
abstract:BACKGROUND:There is a promising outlook regarding the potential effect of spinach-derived thylakoids in the management of obesity and its associated metabolic disturbances. This research aimed to evaluate the effects of spinach-derived thylakoids supplementation combined with a calorie-restricted diet on anthropometric...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00601-4
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Agaro-oligosaccharides derived from red seaweed polysaccharide have been reported to possess antioxidant activity. In order to assess the live protective effects of agar-oligosaccharides, we did both in vitro and in vivo studies based on own-made agaro-oligosaccharides, and the structural information of this...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-5-31
更新日期:2006-12-02 00:00:00
abstract:BACKGROUND:Psychosocial stress leads to altered neuroendocrine functions, such as serotonergic dysfunction, as well as alterations of the autonomic nervous system and the hypothalamic-pituitary-adrenal (HPA)-axis activity resulting in an imbalance between inhibitory and excitatory neurotransmitters. Poor dietary intake...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0030-3
更新日期:2015-05-06 00:00:00
abstract::Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that is characterized by intermittent abdominal pain/discomfort, altered bowel habits and abdominal bloating/distension. This review aimed at presenting the recent developments concerning the role of diet in the pathophysiology and management...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-015-0022-3
更新日期:2015-04-14 00:00:00
abstract:BACKGROUND:Dietary intake of vitamin K has been reported to reduce coronary artery calcification (CAC) and cardiovascular events. However, it is unknown whether supplemental menaquinone (MK)-4 can reduce CAC or arterial stiffness. To study the effect of MK-4 supplementation on CAC and brachial ankle pulse wave velocity...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0175-8
更新日期:2016-05-12 00:00:00
abstract:BACKGROUND:An increasing number of studies in Western countries have shown that healthy dietary patterns may have a protective effect against cognitive decline and dementia. However, information on this relationship among non-Western populations with different cultural settings is extremely limited. We aim to examine t...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-017-0273-2
更新日期:2017-09-11 00:00:00
abstract:BACKGROUND:Few studies have examined whether dietary factors might affect blood pressure in children. We purposed to investigate whether seaweed intake is associated with blood pressure level among Japanese preschool children. METHODS:The design of the study was cross-sectional and it was conducted in autumn 2006. Sub...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-83
更新日期:2011-08-10 00:00:00
abstract::The number of individuals with age-related cognitive impairment is rising dramatically in the UK and globally. There is considerable interest in the general hypothesis that improving the diet of older people may slow the progression of cognitive decline. To date, there has been little attention given to the possible p...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-5-20
更新日期:2006-08-31 00:00:00
abstract:BACKGROUND:The aim of this study was to describe the clinical features, haematological findings and CD4+ and CD8+ cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection. METHODS:The study was conducted in the paediatric wards of Mulago hospital, which is Uganda's nati...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-5-27
更新日期:2006-10-16 00:00:00
abstract:BACKGROUND:Recent studies have shown that body image perception is an important factor in weight control and may be influenced by culture and ethnicity. The aim of the present study was to assess the relationship between immigrant status of the mother and weight status and body image perception of the child. METHODS:I...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-85
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:A number of studies have reported the association between dietary patterns and the risk of chronic kidney disease (CKD), however a consistent perspective hasn't been established to date. Herein, we conducted this systematic review and meta-analysis of observational studies to assess the association between d...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-020-00661-6
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND:This study was designed to determine the glycemic indices of five commonly used varieties of dates in healthy subjects and their effects on postprandial glucose excursions in individuals with type 2 diabetes mellitus. METHODS:Composition analysis was carried out for five types of dates (Tamer stage). The we...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-10-59
更新日期:2011-05-28 00:00:00