Abstract:
BACKGROUND:There is a promising outlook regarding the potential effect of spinach-derived thylakoids in the management of obesity and its associated metabolic disturbances. This research aimed to evaluate the effects of spinach-derived thylakoids supplementation combined with a calorie-restricted diet on anthropometric and metabolic profiles in obese women with the polycystic ovary syndrome (PCOS). METHODS:In a 12-week double-blind placebo-controlled randomized clinical trial, 48 females with obesity and PCOS were randomly allocated into either intervention (5 g/day thylakoid) or placebo (5 g/day cornstarch) groups along with calorie-restricted diets. Anthropometric measures, physical activity levels, dietary intakes, insulin resistance markers, as well as serum levels of insulin, fasting blood glucose (FBG), non-esterified fatty acids (NEFA), and sex hormones including dehydroepiandrosterone sulfate (DHEAS), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex hormone-binding globulin (SHBG), and free androgen index (FAI) were evaluated pre-and post-intervention. RESULTS:After the 12-week intervention, there were significant decreases in weight (- 6.97 ± 0.52 vs. -3.19 ± 0.72 kg; P < 0.001), waist circumference (- 7.78 ± 2.50 vs. -3.73 ± 1.40 cm; P < 0.001), fat mass (- 5.19 ± 0.53 vs. -1.36 ± 0.39 kg; P < 0.001), and insulin levels (- 5.40 ± 1.86 vs. -1.19 ± 0.85 μU/mL; P < 0.001) in the spinach-derived thylakoid group compared to the placebo group. Furthermore, insulin resistance markers and serum levels of testosterone decreased significantly in the thylakoid group compared to the placebo group (P < 0.05). The changes in other parameters did not show significant differences between the two groups. CONCLUSIONS:Spinach-derived thylakoid supplementation resulted in more favorable improvements in anthropometric indices and insulin sensitivity compared to the calorie restriction alone. TRIAL REGISTRATION:The study was approved by the Ethics Committee of Research Vice-chancellor of Tabriz University of Medical Sciences, Tabriz, Iran, and was registered in the Iranian Registry of Clinical Trials (registration ID: IRCT20140907019082N9 ).
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Tabrizi FPF,Farhangi MA,Vaezi M,Hemmati Sdoi
10.1186/s12937-020-00601-4subject
Has Abstractpub_date
2020-08-11 00:00:00pages
82issue
1issn
1475-2891pii
10.1186/s12937-020-00601-4journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences in dietary patterns and physical activity between MHO and metabolically unhealthy obesity (MUO). METHODS:Cross-sectional data of 9270 obese individuals (30-6...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0319-0
更新日期:2018-02-12 00:00:00
abstract:INTRODUCTION:Despite recent interest in the use of ketogenic diets (KDs) for cancer, evidence of beneficial effects is lacking. This study examined the impact of a randomly assigned KD on quality of life, physical activity and biomarkers in patients with breast cancer. METHOD:A total of 80 patients with locally advanc...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00596-y
更新日期:2020-08-22 00:00:00
abstract:BACKGROUND:Obesity is the most relevant overnutrition disease worldwide and is associated to different metabolic disorders such as insulin resistance and type-2 diabetes. Low glycemic load foods and diets and moderately high protein intake have been shown to reduce body weight and fat mass, exerting also beneficial eff...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-10-74
更新日期:2011-07-14 00:00:00
abstract:OBJECTIVES:To determine the effects of isoflavones (soy phyto-estrogens) on serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride (TG). METHODS:We searched electronic databases and included randomized trials with isoflavones interventions i...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-2-15
更新日期:2003-11-19 00:00:00
abstract:BACKGROUND:The freshmen year of college is likely a critical period for risk of weight gain among young-adults. METHODS:A longitudinal observational study was conducted to examine changes in weight, dietary intake, and other health-related behaviors among first-year college students (n = 186) attending a public Univer...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-8-32
更新日期:2009-07-22 00:00:00
abstract:BACKGROUND & OBJECTIVE:Nutrition assessment enables early identification of malnourished patients and those at risk of malnutrition. To determine the prevalence of malnutrition, to analyze the correlation between short-form Mini Nutritional Assessment (MNA-SF) and Nutritional Risk Screening 2002 (NRS2002) with classica...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-015-0054-8
更新日期:2015-07-14 00:00:00
abstract:BACKGROUND:Agaro-oligosaccharides derived from red seaweed polysaccharide have been reported to possess antioxidant activity. In order to assess the live protective effects of agar-oligosaccharides, we did both in vitro and in vivo studies based on own-made agaro-oligosaccharides, and the structural information of this...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-5-31
更新日期:2006-12-02 00:00:00
abstract:BACKGROUND:Associations of dietary patterns in Chinese adolescents and children with later obesity have not previously been investigated. The purpose of the present study was to evaluate the associations between dietary patterns and the risk of obesity in Chinese adolescents and children by using a longitudinal design....
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0372-8
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China. The aim of this study was to assess the iodine status in vulnerable groups from different geogr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-0525-4
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Early enteral nutrition is recommended in cases of critical illness. It is unclear whether this recommendation is of most benefit to extremely ill patients. We aim to determine the association between illness severity and commencement of enteral feeding. METHODS:One hundred and eight critically ill patients...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-30
更新日期:2012-05-03 00:00:00
abstract:BACKGROUND:Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown. OBJECTIVE:This study examined the effec...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-11-98
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Fish consumption and intake of omega-3 fatty acids from fish are associated with a lower risk of cardiovascular disease. However, a prospective study from northern Sweden showed that high consumption of fish is associated with an increased risk of stroke in men, but not in women. The current study aimed to d...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-101
更新日期:2012-12-04 00:00:00
abstract:BACKGROUND:Low diet quality and depression symptoms are independently associated with poor glycemic control in subjects with type 2 diabetes (T2D); however, the relationship between them is unclear. The aim of this study was to determine the association between diet quality and symptoms of depression among Cuban-Americ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-135
更新日期:2011-12-09 00:00:00
abstract:BACKGROUND:Multiple micronutrient deficiencies, in particular iron deficiency anaemia (IDA) is a severe public health problem in Lao People's Democratic Republic (Lao PDR). Because of the practical difficulties encountered in improving the nutritional adequacy of traditional complementary foods and the limitations asso...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-129
更新日期:2011-11-24 00:00:00
abstract:BACKGROUND:Because human diets are composed of a wide variety of nutrients that may work synergistically to prevent or promote disease, assessing dietary nutrient intake status may be informative. The purpose of this study was to assess the dietary nutrient intake status of Chinese adults with metabolic syndrome (MetS)...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-106
更新日期:2013-07-30 00:00:00
abstract:BACKGROUND:Nocturnal eating have recently increased. Serum phosphorus levels and regulators of phosphorus have circadian variations, so it is suggested that the timing of eating may be important in controlling serum phosphorus levels. However, there have been no reports on the effects of nocturnal eating on phosphorus ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0096-y
更新日期:2015-10-08 00:00:00
abstract:BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hor...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-12-137
更新日期:2013-10-11 00:00:00
abstract:BACKGROUND:Multiple sclerosis is a neurodegenerative disorder with a wide range in disease course severity. Many factors seem to be implicated in multiple sclerosis disease course, and diet has been suggested to play a role. Because limited data is present in the literature it was investigated whether variations in die...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-8-36
更新日期:2009-08-10 00:00:00
abstract:BACKGROUND:High fructose corn syrup (HFCS) sweetened soft drink intake has been linked with asthma in US high-schoolers. Intake of beverages with excess free fructose (EFF), including apple juice, and HFCS sweetened fruit drinks and soft drinks, has been associated with asthma in children. One hypothesis for this assoc...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-015-0097-x
更新日期:2015-10-16 00:00:00
abstract:BACKGROUND:Dietary assessment methods that are user-friendly, simple, yet valid are of interest to both researchers and participants, particularly for use in disadvantaged settings, where language barriers and low levels of education are often present. We tested if parents taking photos of what children ate, using mobi...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00558-4
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Limited data exist on the contribution of dietary sources of arsenic to an individual's total exposure, particularly in populations with exposure via drinking water. Here, the association between diet and toenail arsenic concentrations (a long-term biomarker of exposure) was evaluated for individuals with me...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-149
更新日期:2013-11-16 00:00:00
abstract:BACKGROUND:Dietary assessment methods that can provide high quality data while limiting participant burden and resource requirements in epidemiological research are highly sought after and continue to evolve. The use of mobile phone technology in research has increased rapidly over the last decade and offers multiple a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0315-4
更新日期:2018-01-09 00:00:00
abstract:BACKGROUND:In young men, unhealthy lifestyle behaviours can be detrimental to their physical and/or mental health and set them on a negative health trajectory into adulthood. Despite this, there is a lack of evidence to guide development of effective health behaviour change interventions for young men. This study asses...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-017-0227-8
更新日期:2017-01-13 00:00:00
abstract:UNLABELLED:Coeliac disease is an important clinical disorder affecting the human gastrointestinal tract leading to multiple signs and symptoms in different body organs. This disease was the subject of a cross sectional descriptive-analytic study conducted in the Gaza Strip during 2010. Objectives were oriented to ident...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-97
更新日期:2012-11-20 00:00:00
abstract:BACKGROUND:Our previous studies demonstrated that dietary supplementation with milk fat globule membrane (MFGM) combined with habitual exercise improved muscle strength by stimulating neuromuscular development in mice. This study aimed to demonstrate the beneficial effects of dietary MFGM supplementation plus regular e...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0073-5
更新日期:2015-08-25 00:00:00
abstract::Most hepatocellular carcinoma (HCC) patients have complications, including cirrhosis and malnutrition. The efficacy of dietary supplementation with oral branched-chain amino acids (BCAAs) in HCC patients undergoing interventions has not been confirmed. Relevant publications on the efficacy and safety of oral BCAA supp...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12937-015-0056-6
更新日期:2015-07-09 00:00:00
abstract:BACKGROUND:Multiple specialized nutritious food options are programmed for supplementation in humanitarian and development settings. However, comparative cost-effectiveness evidence is lacking, let alone incorporation of perspectives from uncompensated stakeholders. A Burkina Faso trial evaluated the cost-effectiveness...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00535-x
更新日期:2020-02-27 00:00:00
abstract:BACKGROUND:Dietary fibre food intake is related to a reduced risk of developing diabetes mellitus. However, the mechanism of this effect is still not clear. The aim of this study was to evaluate the effect of commercial fibre cereals on the rate of gastric emptying, postprandial glucose response and satiety in healthy ...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1475-2891-6-22
更新日期:2007-09-17 00:00:00
abstract:BACKGROUND:Adolescence is a crucial period for development of dietary behaviors that continue into adulthood and influence the risk of chronic diseases later in life. The aim of this study was to determine the eating patterns of adolescents' and their compliance with the Food Guide Pyramid. METHODS:625 students, aged ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-9-67
更新日期:2010-12-19 00:00:00
abstract:OBJECTIVE:Large preloads of protein and fat have been shown to lower glucose after a carbohydrate-rich meal in people with type 2 diabetes but add a considerable energy burden. Low calorie preloads [<5% of daily energy intake] have been tested in this study in people with prediabetes and with type 2 diabetes. RESEARCH...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-103
更新日期:2014-10-25 00:00:00