Abstract:
:Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that is characterized by intermittent abdominal pain/discomfort, altered bowel habits and abdominal bloating/distension. This review aimed at presenting the recent developments concerning the role of diet in the pathophysiology and management of IBS. There is no convincing evidence that IBS patients suffer from food allergy/intolerance, and there is no evidence that gluten causes the debated new diagnosis of non-coeliac gluten sensitivity (NCGS). The component in wheat that triggers symptoms in NCGS appears to be the carbohydrates. Patients with NCGS appear to be IBS patients who are self-diagnosed and self-treated with a gluten-free diet. IBS symptoms are triggered by the consumption of the poorly absorbed fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) and insoluble fibre. On reaching the distal small intestine and colon, FODMAPS and insoluble fibre increase the osmotic pressure in the large-intestine lumen and provide a substrate for bacterial fermentation, with consequent gas production, abdominal distension and abdominal pain or discomfort. Poor FODMAPS and insoluble fibres diet reduces the symptom and improve the quality of life in IBS patients. Moreover, it changes favourably the intestinal microbiota and restores the abnormalities in the gastrointestinal endocrine cells. Five gastrointestinal endocrine cell types that produce hormones regulating appetite and food intake are abnormal in IBS patients. Based on these hormonal abnormalities, one would expect that IBS patients to have increased food intake and body weight gain. However, the link between obesity and IBS is not fully studied. Individual dietary guidance for intake of poor FODMAPs and insoluble fibres diet in combination with probiotics intake and regular exercise is to be recommended for IBS patients.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
El-Salhy M,Gundersen Ddoi
10.1186/s12937-015-0022-3subject
Has Abstractpub_date
2015-04-14 00:00:00pages
36issn
1475-2891pii
10.1186/s12937-015-0022-3journal_volume
14pub_type
杂志文章,评审abstract:BACKGROUND:Among natural compounds, present in every day diet, flavonoids have shown beneficial effect in prevention of cardiovascular diseases that can be attributed, at least partially to the described antiaggregatory activity i.e. antiplatelet effects of flavonoids. Due to the ever increasing pharmacological interes...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-73
更新日期:2011-07-11 00:00:00
abstract:BACKGROUND:Low diet quality and depression symptoms are independently associated with poor glycemic control in subjects with type 2 diabetes (T2D); however, the relationship between them is unclear. The aim of this study was to determine the association between diet quality and symptoms of depression among Cuban-Americ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-135
更新日期:2011-12-09 00:00:00
abstract:BACKGROUND:Agaro-oligosaccharides derived from red seaweed polysaccharide have been reported to possess antioxidant activity. In order to assess the live protective effects of agar-oligosaccharides, we did both in vitro and in vivo studies based on own-made agaro-oligosaccharides, and the structural information of this...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-5-31
更新日期:2006-12-02 00:00:00
abstract:BACKGROUND:Obesity leads to an increase in inflammation and insulin resistance. This study determined antioxidant activity of flaxseed and its role in inflammation and insulin resistance in obese glucose intolerant people. METHODS:Using a randomized crossover design, nine obese glucose intolerant people consumed 40 g ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-44
更新日期:2011-05-09 00:00:00
abstract:BACKGROUND:The association between milk and dairy intake and the incidence of cardiometabolic diseases, cancer and mortality has been evaluated in many studies, but these studies have had conflicting results with no clear conclusion on causal or confounding associations. The present study aims to further address this a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0418-y
更新日期:2018-11-22 00:00:00
abstract:BACKGROUND:Measuring the effects of the acute intake of natural products on human biomarker concentrations, such as those related to oxidation and inflammation, can be an advantageous strategy for early clinical research on an ingredient or product. METHODS:31 total healthy subjects were randomized in a double-blinded...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-67
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:Epidemiological studies regarding the association between dietary fiber intake and ovarian cancer risk are still inconsistent. We aimed to review the available evidence and conduct a dose-response meta-analysis to investigate the relationship between dietary fiber intake and ovarian cancer risk. METHODS:Rel...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12937-018-0407-1
更新日期:2018-10-30 00:00:00
abstract::Public health policies, including in Europe, are considering measures and recommendations to limit the intake of added or free sugars. For such policies to be efficient and monitored, a precise knowledge of the current situation regarding sugar intake in Europe is needed. This review summarizes published or re-analyze...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0225-2
更新日期:2017-01-21 00:00:00
abstract:BACKGROUND:Information regarding dietary patterns associated with prediabetes in the Chinese population is lacking. The objective of the present study was to explore the association between major dietary patterns and the risk of prediabetes in a middle-aged Chinese population. METHODS:A total of 1761 participants (age...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00593-1
更新日期:2020-07-30 00:00:00
abstract:BACKGROUND:Nocturnal eating have recently increased. Serum phosphorus levels and regulators of phosphorus have circadian variations, so it is suggested that the timing of eating may be important in controlling serum phosphorus levels. However, there have been no reports on the effects of nocturnal eating on phosphorus ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0096-y
更新日期:2015-10-08 00:00:00
abstract:BACKGROUND:Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences in dietary patterns and physical activity between MHO and metabolically unhealthy obesity (MUO). METHODS:Cross-sectional data of 9270 obese individuals (30-6...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0319-0
更新日期:2018-02-12 00:00:00
abstract:BACKGROUND:The primary aim of this study was to test the hypothesis that an orally ingested apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers improves endothelium-dependent brachial artery flow-mediated vasodilatation (FMD) in volunteers with borderline hypertension. The secondary aim of the study ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-017-0291-0
更新日期:2017-10-27 00:00:00
abstract::Several observational studies suggest an association between coffee intake and hip fracture risk. However, the results among them are inconsistent. We aimed to evaluate the association between coffee consumption and risk of hip fracture by performing a meta-analysis of prospective cohort studies. PubMed, Embase, and W...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12937-015-0025-0
更新日期:2015-04-18 00:00:00
abstract:BACKGROUND:Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and early mortality. Excessive shortening of telomere is a marker of accelerated aging and can be influenced by oxidative stress and nutritional deficiency. Plasma n6:n3 polyunsaturated fatty acid...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00626-9
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:In observational studies anaemia and iron deficiency are associated with cognitive deficits, suggesting that iron supplementation may improve cognitive function. However, due to the potential for confounding by socio-economic status in observational studies, this needs to be verified in data from randomised ...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1475-2891-9-4
更新日期:2010-01-25 00:00:00
abstract:BACKGROUND:Vitamin D inadequacy is common among the elderly, especially within the Asian population. The vitamin D status among healthy adults in the elderly Chinese population was evaluated. METHODS:A total of 6014 healthy adults aged 60 years or older (2948 men, 3066 women) participated in this descriptive cross-sec...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0224-3
更新日期:2017-01-14 00:00:00
abstract:BACKGROUND:Recent studies have shown that body image perception is an important factor in weight control and may be influenced by culture and ethnicity. The aim of the present study was to assess the relationship between immigrant status of the mother and weight status and body image perception of the child. METHODS:I...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-85
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:Tocotrienols (T3) and tocopherols (T), both members of the natural vitamin E family have unique biological functions in humans. T3 are detected in circulating human plasma and lipoproteins, although at concentrations significantly lower than α-tocopherol (α-T). T3, especially α-T3 is known to be neuropotecti...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-5
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri E®) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-37
更新日期:2011-04-23 00:00:00
abstract:OBJECTIVE:To evaluate the association between the consumption of unhealthy foods in children under one year and the education level of the mothers, data obtained from participants of the II Survey on the prevalence of breastfeeding in the Brazilian capitals and the Federal District in 2008 was analyzed. METHODS:During...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-33
更新日期:2014-04-03 00:00:00
abstract:BACKGROUND:Psychosocial stress leads to altered neuroendocrine functions, such as serotonergic dysfunction, as well as alterations of the autonomic nervous system and the hypothalamic-pituitary-adrenal (HPA)-axis activity resulting in an imbalance between inhibitory and excitatory neurotransmitters. Poor dietary intake...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0030-3
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hor...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-12-137
更新日期:2013-10-11 00:00:00
abstract:BACKGROUND:Dietary fibre food intake is related to a reduced risk of developing diabetes mellitus. However, the mechanism of this effect is still not clear. The aim of this study was to evaluate the effect of commercial fibre cereals on the rate of gastric emptying, postprandial glucose response and satiety in healthy ...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1475-2891-6-22
更新日期:2007-09-17 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human ...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0191-8
更新日期:2016-08-02 00:00:00
abstract:BACKGROUND:We have previously shown that a combination of glucosyl hesperidin (G-hesperidin) plus caffeine reduces accumulation of body fat, whereas G-hesperidin or caffeine alone shows little effect on high-fat diet-induced obesity in mice. The aim of this study is to evaluate the anti-obesity effect of G-hesperidin p...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-016-0123-7
更新日期:2016-01-19 00:00:00
abstract:BACKGROUND:Inadequate protein intake is known to be deleterious in animals. Using WHO consensus documents for human nutrient requirements, the protein:energy ratio (P:E) of an adequate diet is > 5%. Cassava has a very low protein content. This study tested the hypothesis that Nigerian and Kenyan children consuming cass...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-9-9
更新日期:2010-02-26 00:00:00
abstract:BACKGROUND:The 12-month Healthy Foods North intervention program was developed to improve diet among Inuit and Inuvialuit living in Arctic Canada and assess the impact of the intervention established for the communities. METHODS:A quasi-experimental study randomly selected men and women (≥19 years of age) in six remot...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-68
更新日期:2014-07-04 00:00:00
abstract:BACKGROUND:Fish consumption and intake of omega-3 fatty acids from fish are associated with a lower risk of cardiovascular disease. However, a prospective study from northern Sweden showed that high consumption of fish is associated with an increased risk of stroke in men, but not in women. The current study aimed to d...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-101
更新日期:2012-12-04 00:00:00
abstract:BACKGROUND:Vitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (<10 ng...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-017-0285-y
更新日期:2017-09-18 00:00:00
abstract:BACKGROUND:There is a promising outlook regarding the potential effect of spinach-derived thylakoids in the management of obesity and its associated metabolic disturbances. This research aimed to evaluate the effects of spinach-derived thylakoids supplementation combined with a calorie-restricted diet on anthropometric...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00601-4
更新日期:2020-08-11 00:00:00