Abstract：
BACKGROUND:Agaro-oligosaccharides derived from red seaweed polysaccharide have been reported to possess antioxidant activity. In order to assess the live protective effects of agar-oligosaccharides, we did both in vitro and in vivo studies based on own-made agaro-oligosaccharides, and the structural information of this oligosaccharide was also determined. METHOD:Structure of agaro-oligosaccharides prepared with acid hydrolysis on agar was confirmed by matrix-assisted ultraviolet laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) and NMR. The antioxidant effect of agaro-oligosaccharides on intracellular reactive oxygen species (ROS) was assessed by 2', 7'-dichlorofluorescin diacetate. Carbon tetrachloride was used to induce liver injury, some index including SOD, GSH-Px, MDA, AST, ALT were examined to determine the hepatoprotective effect of agaro-oligosaccharides. RESULTS:Agaro-oligosaccharides we got were composed of odd polymerizations with molecular weights ranged from 500 to 2500. Results from intracellular test indicated that agaro-oligosaccharides could significantly scavenge the level of oxidants in the hepatocytes, more beneficially, also associated with the improvement of cell viability In vivo studies of the antioxidant effects on tissue peroxidative damage induced by carbon tetrachloride in rat model indicated that agaro-oligosaccharides could elevate the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and decrease the level of malondialdehyde (MDA), glutamate oxaloacetate transaminase (AST), glutamic pyruvic transaminase (ALT) significantly. At 400 mg/kg, MDA level reduced 44 % and 21 % in liver and heart, SOD and GSH-Px increased to highest in liver and serum, while ALT level decreased 22.16 % in serum. CONCLUSION:Overall, the results of the present study indicate that agaro-oligosaccharides can exert their in vitro and in vivo hepatoprotective effect through scavenging oxidative damage induced by ROS.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Chen H,Yan X,Zhu P,Lin Jdoi
10.1186/1475-2891-5-31subject
Has Abstractpub_date
2006-12-02 00:00:00pages
31issn
1475-2891pii
1475-2891-5-31journal_volume
5pub_type
杂志文章abstract：BACKGROUND:Previous studies suggested that the abnormality of metabolism is a newly identified risk factor in HBV-related hepatocellular carcinoma (HCC). The association between metabolic factors and hepatocellular carcinoma (HCC) has not been clarified up to now. This study was conducted to investigate the prevalence ...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-10-49
更新日期：2011-05-15 00:00:00
abstract：BACKGROUND:To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada. METHODS:A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, ...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-12-70
更新日期：2013-06-02 00:00:00
abstract：BACKGROUND:Adolescence is a crucial period for development of dietary behaviors that continue into adulthood and influence the risk of chronic diseases later in life. The aim of this study was to determine the eating patterns of adolescents' and their compliance with the Food Guide Pyramid. METHODS:625 students, aged ...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-9-67
更新日期：2010-12-19 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human ...
journal_title：Nutrition journal
pub_type： 杂志文章,评审
doi：10.1186/s12937-016-0191-8
更新日期：2016-08-02 00:00:00
abstract：BACKGROUND:Inadequate protein intake is known to be deleterious in animals. Using WHO consensus documents for human nutrient requirements, the protein:energy ratio (P:E) of an adequate diet is > 5%. Cassava has a very low protein content. This study tested the hypothesis that Nigerian and Kenyan children consuming cass...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-9-9
更新日期：2010-02-26 00:00:00
abstract：BACKGROUND:Insufficient iodine in children's diets is of concern because thyroid hormones are needed for normal growth and development, particularly of the brain. This study aimed to carry out a comprehensive assessment of the iodine status of New Zealand schoolchildren using a range of biochemical indices suitable for...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-11-31
更新日期：2012-05-08 00:00:00
abstract：BACKGROUND:Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. METHODS:We included 100 overweight and obese adults (...
journal_title：Nutrition journal
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12937-017-0229-6
更新日期：2017-02-06 00:00:00
abstract：OBJECTIVE:To evaluate the association between the consumption of unhealthy foods in children under one year and the education level of the mothers, data obtained from participants of the II Survey on the prevalence of breastfeeding in the Brazilian capitals and the Federal District in 2008 was analyzed. METHODS:During...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-13-33
更新日期：2014-04-03 00:00:00
abstract：BACKGROUND:Micronutrient inadequate intake is responsible of pathological deficiencies and there is a need of assessing the effectiveness of metal supplementation, frequently proposed to rebalance poor diets. Manganese (Mn) is present in many enzymatic intracellular systems crucial for the regulation of cell metabolism...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-10-77
更新日期：2011-07-25 00:00:00
abstract：BACKGROUND:Multiple micronutrient deficiencies, in particular iron deficiency anaemia (IDA) is a severe public health problem in Lao People's Democratic Republic (Lao PDR). Because of the practical difficulties encountered in improving the nutritional adequacy of traditional complementary foods and the limitations asso...
journal_title：Nutrition journal
pub_type： 杂志文章,随机对照试验
doi：10.1186/1475-2891-10-129
更新日期：2011-11-24 00:00:00
abstract：BACKGROUND:Our previous studies demonstrated that dietary supplementation with milk fat globule membrane (MFGM) combined with habitual exercise improved muscle strength by stimulating neuromuscular development in mice. This study aimed to demonstrate the beneficial effects of dietary MFGM supplementation plus regular e...
journal_title：Nutrition journal
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12937-015-0073-5
更新日期：2015-08-25 00:00:00
abstract：AIM:To study the association between the expression of H3K27me3 and ACat2 (a folate metabolic protein), in order to elucidate the protective mechanism of folic acid (FA) in neural tube defects (NTDs). METHODS:Eighteen female SD rats were randomly divided into normal, NTD and FA group. NTD group was induced by all-tran...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/s12937-016-0212-7
更新日期：2016-11-03 00:00:00
abstract：:Several observational studies suggest an association between coffee intake and hip fracture risk. However, the results among them are inconsistent. We aimed to evaluate the association between coffee consumption and risk of hip fracture by performing a meta-analysis of prospective cohort studies. PubMed, Embase, and W...
journal_title：Nutrition journal
pub_type： 杂志文章,meta分析
doi：10.1186/s12937-015-0025-0
更新日期：2015-04-18 00:00:00
abstract：BACKGROUND:Prebiotics are food ingredients, usually non-digestible oligosaccharides, that are selectively fermented by populations of beneficial gut bacteria. Endoxylanases, altering the naturally present cereal arabinoxylans, are commonly used in the bread industry to improve dough and bread characteristics. Recently,...
journal_title：Nutrition journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1186/1475-2891-11-36
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:Cinnamon is currently marketed as a remedy for obesity, glucose intolerance, diabetes mellitus and dyslipidaemia. Integrative medicine is a new concept that combines conventional treatment with evidence-based complementary therapies. AIM:The aim of this review is to critically evaluate the experimental ev...
journal_title：Nutrition journal
pub_type： 杂志文章,评审
doi：10.1186/s12937-015-0098-9
更新日期：2015-10-16 00:00:00
abstract：BACKGROUND:Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China. The aim of this study was to assess the iodine status in vulnerable groups from different geogr...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/s12937-020-0525-4
更新日期：2020-01-21 00:00:00
abstract：BACKGROUND:Dietary intakes are suggested to affect age at menopause but associations between dietary factors and ovarian reserve reduction have not yet been investigated. We aimed to examine dietary intakes in relation to the rate of decline in anti-Mullerian hormone (AMH), an indicator of ovarian reserve, in a general...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/s12937-019-0508-5
更新日期：2019-12-02 00:00:00
abstract：BACKGROUND:One of the driving factors of dietary overconsumption throughout the last decennia is the increase of food portion sizes. Larger portions induce higher daily energy intake, so reducing portion size may reduce intake of excess calories. However, real-life studies about the effects of portion size reduction ar...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/s12937-018-0352-z
更新日期：2018-04-13 00:00:00
abstract：BACKGROUND:Malnutrition is a widespread problem in elderly people and is associated with cognitive decline. However, interventional studies have produced ambiguous results. For this reason, we wanted to determine the effect of micronutrient supplementation on blood and tissue levels and on general nutritional status in...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-12-148
更新日期：2013-11-15 00:00:00
abstract：BACKGROUND:This study examined the association of breakfast consumption, and the type of breakfast consumed, with body mass index (BMI; kg/m(2)) and prevalence rates and odds ratios (OR) of overweight/obesity among Canadian adults. These associations were examined by age group and sex. METHODS:We used data from non-pr...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/s12937-016-0151-3
更新日期：2016-03-31 00:00:00
abstract：BACKGROUND:The primary aim of this study was to test the hypothesis that an orally ingested apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers improves endothelium-dependent brachial artery flow-mediated vasodilatation (FMD) in volunteers with borderline hypertension. The secondary aim of the study ...
journal_title：Nutrition journal
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12937-017-0291-0
更新日期：2017-10-27 00:00:00
abstract：BACKGROUND:Isoflavones comprise a class of phytoestrogens that resemble human estrogen in chemical structure, and have weak estrogenic effects. Because estrogen modulates sleep duration and quality, we hypothesized that isoflavones would have a beneficial effect on sleep status in a way similar to estrogen. We conducte...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/s12937-015-0117-x
更新日期：2015-12-29 00:00:00
abstract：BACKGROUND:The aim of this study was to describe the clinical features, haematological findings and CD4+ and CD8+ cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection. METHODS:The study was conducted in the paediatric wards of Mulago hospital, which is Uganda's nati...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-5-27
更新日期：2006-10-16 00:00:00
abstract：BACKGROUND:Nocturnal eating have recently increased. Serum phosphorus levels and regulators of phosphorus have circadian variations, so it is suggested that the timing of eating may be important in controlling serum phosphorus levels. However, there have been no reports on the effects of nocturnal eating on phosphorus ...
journal_title：Nutrition journal
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12937-015-0096-y
更新日期：2015-10-08 00:00:00
abstract：OBJECTIVE:The purpose of this study was to examine the timing of introduction of complementary (solid) foods among infants in South Western Sydney, Australia, and describe the maternal and infant characteristics associated with very early introduction of solids. METHODS:Mother-infant dyads (n = 1035) were recruited in...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/s12937-020-0528-1
更新日期：2020-02-18 00:00:00
abstract：BACKGROUND:Tocotrienols (T3) and tocopherols (T), both members of the natural vitamin E family have unique biological functions in humans. T3 are detected in circulating human plasma and lipoproteins, although at concentrations significantly lower than α-tocopherol (α-T). T3, especially α-T3 is known to be neuropotecti...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/1475-2891-11-5
更新日期：2012-01-17 00:00:00
abstract：BACKGROUND:Preterm birth is the leading cause of death in children under five. A recent Cochrane review found a 42% reduction in early preterm birth (< 34 weeks' gestation) and 11% reduction in preterm birth (< 37 weeks' gestation) with omega-3 fatty acid supplementation. To assist in the development of implementation ...
journal_title：Nutrition journal
pub_type： 杂志文章
doi：10.1186/s12937-019-0499-2
更新日期：2019-11-14 00:00:00
abstract：BACKGROUND:High level of serum cholesterol is considered to be a major risk factor for cardiovascular disease (CVD). A double-blinded, randomized, placebo-controlled trial was performed to test the hypothesis that a daily intake of Chlorella may improve serum lipid profile through enhancement of serum carotenoid concen...
journal_title：Nutrition journal
pub_type： 杂志文章,随机对照试验
doi：10.1186/1475-2891-13-57
更新日期：2014-06-11 00:00:00
abstract：BACKGROUND:Decreased ability of muscles to respond to anabolic stimuli is part of the underlying mechanism for muscle loss with aging. Previous studies suggest that substantial amounts of essential amino acids (EAA), whey protein and leucine are beneficial for stimulation of acute muscle protein synthesis in older adul...
journal_title：Nutrition journal
pub_type： 杂志文章,随机对照试验
doi：10.1186/1475-2891-13-9
更新日期：2014-01-22 00:00:00
abstract：BACKGROUND:The benefit of FV intake in old age is well documented. However, there is evidence that old people do not consume enough FV. The purpose of this study was to evaluate the effectiveness of a tailored nutrition intervention that aimed to increase the FV intake among elderly Iranians aged 60 and over. METHODS:...
journal_title：Nutrition journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1475-2891-10-123
更新日期：2011-11-14 00:00:00
