Abstract:
BACKGROUND:Micronutrient inadequate intake is responsible of pathological deficiencies and there is a need of assessing the effectiveness of metal supplementation, frequently proposed to rebalance poor diets. Manganese (Mn) is present in many enzymatic intracellular systems crucial for the regulation of cell metabolism, and is contained in commercially available metal supplements. METHODS:We compared the effects of two different commercial Mn forms, gluconate (MnGluc) and oxyprolinate (MnOxP). For this purpose we used the polarized Caco-2 cells cultured on transwell filters, an established in vitro model of intestinal epithelium. Since micronutrient deficiency may accelerate mitochondrial efficiency, the mitochondrial response of these cells, in the presence of MnGluc and MnOxP, by microscopy methods and by ATP luminescence assay was used. RESULTS:In the presence of both MnOxP and MnGluc a sustained mitochondrial activity was shown by mitoTraker labeling (indicative of mitochondrial respiration), but ATP intracellular content remained comparable to untreated cells only in the presence of MnOxP. In addition MnOxP transiently up-regulated the antioxidant enzyme Mn superoxide dismutase more efficiently than MnGluc. Both metal treatments preserved NADH and βNADPH diaphorase oxidative activity, avoided mitochondrial dysfunction, as assessed by the absence of a sustained phosphoERK activation, and were able to maintain cell viability. CONCLUSIONS:Collectively, our data indicate that MnOxP and MnGluc, and primarily the former, produce a moderate and safe modification of Caco-2 cell metabolism, by activating positive enzymatic mechanisms, thus could contribute to long-term maintenance of cell homeostasis.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Foglieni C,Cavarelli M,Piscopiello M,Fulgenzi A,Ferrero MEdoi
10.1186/1475-2891-10-77subject
Has Abstractpub_date
2011-07-25 00:00:00pages
77issn
1475-2891pii
1475-2891-10-77journal_volume
10pub_type
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pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-103
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pub_type: 杂志文章
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journal_title:Nutrition journal
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
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更新日期:2011-05-09 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Nutrition journal
pub_type: 杂志文章
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journal_title:Nutrition journal
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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