Abstract:
BACKGROUND:Among natural compounds, present in every day diet, flavonoids have shown beneficial effect in prevention of cardiovascular diseases that can be attributed, at least partially to the described antiaggregatory activity i.e. antiplatelet effects of flavonoids. Due to the ever increasing pharmacological interest in antiplatelet agents a systematic experimental evaluation of large flavonoid series is needed. METHODS:A set of thirty flavonoid aglycones has been selected for the evaluation. All measurements of aggregation were done under standardized and firmly controlled in vitro conditions. The whole blood samples, multiple platelet functional analyzer and adenosine diphosphate (ADP) as a weak agonist of aggregation were selected for this purpose. RESULTS:The results were expressed as minimal concentration of flavonoid that can significantly lower the platelet aggregation compared to the corresponding untreated sample (minimal antiaggregatory concentration--MINaAC). All analyzed flavonoids exhibited antiaggregatory activity MINaAC ranging from 0.119 μM to 122 μM, while the most potent representatives were 3,6-dihydroxyflavone (0.119 μM) and syringetin (0.119 μM). CONCLUSIONS:Measurable antiplatelet activity established at submicromolar flavonoid concentrations suggests that even a dietary consumption of some flavonoids can make an impact on in vivo aggregation of platelets. These findings also point out a therapeutical potential of some flavonoids.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Bojić M,Debeljak Z,Tomičić M,Medić-Šarić M,Tomić Sdoi
10.1186/1475-2891-10-73subject
Has Abstractpub_date
2011-07-11 00:00:00pages
73issn
1475-2891pii
1475-2891-10-73journal_volume
10pub_type
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journal_title:Nutrition journal
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:Several studies have shown that cocoa and cocoa-containing foods have the potential to lower blood pressure and improve endothelial function. Most of the studies reporting the beneficial effects of dark chocolate on blood pressure have been short (≤ 4 weeks). The aim of the present 8-wks (weeks) study was to...
journal_title:Nutrition journal
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journal_title:Nutrition journal
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pub_type: 杂志文章
doi:10.1186/1475-2891-10-53
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更新日期:2018-02-12 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2015-12-12 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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