Abstract:
BACKGROUND:The primary aim of this study was to test the hypothesis that an orally ingested apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers improves endothelium-dependent brachial artery flow-mediated vasodilatation (FMD) in volunteers with borderline hypertension. The secondary aim of the study was to test whether the investigational product would improve endothelium-independent nitrate-mediated vasodilatation (NMD). METHODS:This was a single centre, repeated-dose, double-blind, placebo-controlled, crossover study in 60 otherwise healthy subjects (26 men, 34 women; aged 40-65 years) with borderline hypertension (blood pressure 130-139/85-89 mmHg) or unmedicated mild hypertension (blood pressure 140-165/90-95 mmHg). The subjects were randomised to receive placebo or the apple polyphenol extract to provide a daily dose of 100 mg epicatechin for 4 weeks, followed by a four to five-week wash-out period, and then 4 weeks intake of the product that they did not receive during the first treatment period. FMD and NMD of the left brachial artery were investigated with ultrasonography at the start and end of both treatment periods, and the per cent increase of the arterial diameter (FMD% and NMD%) was calculated. RESULTS:With the apple extract treatment, a significant acute improvement was detected in the mean change of maximum FMD% at the first visit 1.16 (p = 0.04, 95% CI: 0.04; 2.28), last visit 1.37 (p = 0.02, 95% CI: 0.22; 2.52) and for both visits combined 1.29 (p < 0.01, 95% CI: 0.40; 2.18). However, such improvement was not statistically significant when apple extract was compared with placebo. The overall long-term effect of apple extract on FMD% was not different from placebo. No statistically significant differences between the apple extract and placebo treatments were observed for endothelium-independent NMD. CONCLUSIONS:A significant acute improvement in maximum FMD% with apple extract administration was found. However, superiority of apple extract over placebo was not statistically significant in our study subjects with borderline hypertension or mild hypertension. The study raised no safety concerns regarding the daily administration of an apple polyphenol extract rich in epicatechin. TRIAL REGISTRATION:The trial is registered at http://clinicaltrials.gov (identifier: NCT01690676 ). Registered 25th May 2012.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Saarenhovi M,Salo P,Scheinin M,Lehto J,Lovró Z,Tiihonen K,Lehtinen MJ,Junnila J,Hasselwander O,Tarpila A,Raitakari OTdoi
10.1186/s12937-017-0291-0subject
Has Abstractpub_date
2017-10-27 00:00:00pages
73issue
1issn
1475-2891pii
10.1186/s12937-017-0291-0journal_volume
16pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFAs) and better cognitive outcomes in older adults. To date, only two randomised, controlled trials have assessed the effect of n-3 LC PUFA supplementation on cognitive function in older cognitively he...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-117
更新日期:2011-10-20 00:00:00
abstract:BACKGROUND:Tocotrienols (T3) and tocopherols (T), both members of the natural vitamin E family have unique biological functions in humans. T3 are detected in circulating human plasma and lipoproteins, although at concentrations significantly lower than α-tocopherol (α-T). T3, especially α-T3 is known to be neuropotecti...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-5
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:The freshmen year of college is likely a critical period for risk of weight gain among young-adults. METHODS:A longitudinal observational study was conducted to examine changes in weight, dietary intake, and other health-related behaviors among first-year college students (n = 186) attending a public Univer...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-8-32
更新日期:2009-07-22 00:00:00
abstract:BACKGROUND:Because human diets are composed of a wide variety of nutrients that may work synergistically to prevent or promote disease, assessing dietary nutrient intake status may be informative. The purpose of this study was to assess the dietary nutrient intake status of Chinese adults with metabolic syndrome (MetS)...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-106
更新日期:2013-07-30 00:00:00
abstract:BACKGROUND:The eating habits have changed in the last few decades, but few studies prioritize the food consumption of farmers and the rural population. Therefore, the objective of this study was explore the sociodemographic, occupational and lifestyle factors to the high adherence these dietary patterns. METHODS:This ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00542-y
更新日期:2020-03-24 00:00:00
abstract:BACKGROUND:This study investigated the effect of fermented milk supplementation on glucose metabolism associated with muscle damage after acute exercise in humans. METHODS:Eighteen healthy young men participated in each of the three trials of the study: rest, exercise with placebo, and exercise with fermented milk. In...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-83
更新日期:2013-06-16 00:00:00
abstract:BACKGROUND:The association between milk and dairy intake and the incidence of cardiometabolic diseases, cancer and mortality has been evaluated in many studies, but these studies have had conflicting results with no clear conclusion on causal or confounding associations. The present study aims to further address this a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0418-y
更新日期:2018-11-22 00:00:00
abstract:BACKGROUND:This study examined the association of breakfast consumption, and the type of breakfast consumed, with body mass index (BMI; kg/m(2)) and prevalence rates and odds ratios (OR) of overweight/obesity among Canadian adults. These associations were examined by age group and sex. METHODS:We used data from non-pr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0151-3
更新日期:2016-03-31 00:00:00
abstract:OBJECTIVES:To determine the effects of isoflavones (soy phyto-estrogens) on serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride (TG). METHODS:We searched electronic databases and included randomized trials with isoflavones interventions i...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-2-15
更新日期:2003-11-19 00:00:00
abstract:BACKGROUND:Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri E®) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-37
更新日期:2011-04-23 00:00:00
abstract:AIM:To study the association between the expression of H3K27me3 and ACat2 (a folate metabolic protein), in order to elucidate the protective mechanism of folic acid (FA) in neural tube defects (NTDs). METHODS:Eighteen female SD rats were randomly divided into normal, NTD and FA group. NTD group was induced by all-tran...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0212-7
更新日期:2016-11-03 00:00:00
abstract:BACKGROUND:Obesity develops when energy intake continuously exceeds energy expenditure, causing a fundamental chronic energy imbalance. Societal and behavioural changes over the last decades are held responsible for the considerable increase in sedentary lifestyles and inappropriate dietary patterns. The role of dietar...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-6-26
更新日期:2007-09-21 00:00:00
abstract::A sex- and gender-informed approach to study design, analysis and reporting has particular relevance to the transgender and gender nonconforming population (TGNC) where sex and gender identity differ. Notable research gaps persist related to dietary intake, validity and reliability of nutrition assessment methods, and...
journal_title:Nutrition journal
pub_type: 信件
doi:10.1186/s12937-021-00662-z
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Consumption of sugar-sweetened beverages, such as soda, have been shown to play an important role in weight gain. Although soda consumption has been associated with body mass index (BMI) in many studies, it has been difficult to ascertain a true causal relationship between soda consumption and BMI for two re...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-017-0269-y
更新日期:2017-08-22 00:00:00
abstract:BACKGROUND:Preterm birth is the leading cause of death in children under five. A recent Cochrane review found a 42% reduction in early preterm birth (< 34 weeks' gestation) and 11% reduction in preterm birth (< 37 weeks' gestation) with omega-3 fatty acid supplementation. To assist in the development of implementation ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0499-2
更新日期:2019-11-14 00:00:00
abstract:BACKGROUND:Multiple micronutrient deficiencies, in particular iron deficiency anaemia (IDA) is a severe public health problem in Lao People's Democratic Republic (Lao PDR). Because of the practical difficulties encountered in improving the nutritional adequacy of traditional complementary foods and the limitations asso...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-129
更新日期:2011-11-24 00:00:00
abstract:BACKGROUND:Metabolic syndrome is commonly associated with inflammation. The underlying factors of inflammation in metabolic syndrome are not fully understood. The objective of the study was to determine the association of dietary patterns, anthropometric measurements, and metabolic parameters with inflammatory markers ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0417-z
更新日期:2018-11-19 00:00:00
abstract:BACKGROUND:Antenatal vitamin D status may be associated with the risk of adverse pregnancy and neonatal outcomes; however, the benefits of vitamin D supplementation during pregnancy remain unknown. METHODS:We conducted a double-blind placebo-controlled randomized trial to evaluate the effect of high-dose prenatal 3rd ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-47
更新日期:2013-04-12 00:00:00
abstract:BACKGROUND:Multiple specialized nutritious food options are programmed for supplementation in humanitarian and development settings. However, comparative cost-effectiveness evidence is lacking, let alone incorporation of perspectives from uncompensated stakeholders. A Burkina Faso trial evaluated the cost-effectiveness...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00535-x
更新日期:2020-02-27 00:00:00
abstract:BACKGROUND:Information regarding dietary patterns associated with prediabetes in the Chinese population is lacking. The objective of the present study was to explore the association between major dietary patterns and the risk of prediabetes in a middle-aged Chinese population. METHODS:A total of 1761 participants (age...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00593-1
更新日期:2020-07-30 00:00:00
abstract:BACKGROUND:Based on data obtained from pregnant women who participated in the Mothers and Children's Environmental Health (MOCEH) study in South Korea, we aimed to determine whether maternal intake of fruits and vegetables or vitamin C is associated with fetal and infant growth. METHODS:A total of 1138 Korean pregnant...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究
doi:10.1186/s12937-018-0410-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hor...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-12-137
更新日期:2013-10-11 00:00:00
abstract:BACKGROUND:Among natural compounds, present in every day diet, flavonoids have shown beneficial effect in prevention of cardiovascular diseases that can be attributed, at least partially to the described antiaggregatory activity i.e. antiplatelet effects of flavonoids. Due to the ever increasing pharmacological interes...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-73
更新日期:2011-07-11 00:00:00
abstract:BACKGROUND:Many consumers avoid eating beans because they believe legume consumption will cause excessive intestinal gas or flatulence. An increasing body of research and the 2010 Dietary Guidelines for Americans supports the benefits of a plant-based diet, and legumes specifically, in the reduction of chronic disease ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-128
更新日期:2011-11-21 00:00:00
abstract:BACKGROUND:Because children have been advised on the dangers of sun exposure, diet is an important contributor of serum 25 hydroxyvitamin D [25(OH)D] concentrations. Aim of this study was to determine whether serum 25(OH)D concentrations were associated with any specific dietary patterns in US children. METHODS:Data f...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0365-7
更新日期:2018-06-04 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the timing of introduction of complementary (solid) foods among infants in South Western Sydney, Australia, and describe the maternal and infant characteristics associated with very early introduction of solids. METHODS:Mother-infant dyads (n = 1035) were recruited in...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-0528-1
更新日期:2020-02-18 00:00:00
abstract:BACKGROUND:There are several methods of assessing nutritional status in cancer of which serum albumin is one of the most commonly used. In recent years, the role of malnutrition as a predictor of survival in cancer has received considerable attention. As a result, it is reasonable to investigate whether serum albumin h...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-9-69
更新日期:2010-12-22 00:00:00
abstract:BACKGROUND:Decreased ability of muscles to respond to anabolic stimuli is part of the underlying mechanism for muscle loss with aging. Previous studies suggest that substantial amounts of essential amino acids (EAA), whey protein and leucine are beneficial for stimulation of acute muscle protein synthesis in older adul...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-9
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:Dietary intakes are suggested to affect age at menopause but associations between dietary factors and ovarian reserve reduction have not yet been investigated. We aimed to examine dietary intakes in relation to the rate of decline in anti-Mullerian hormone (AMH), an indicator of ovarian reserve, in a general...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0508-5
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Insufficient iodine in children's diets is of concern because thyroid hormones are needed for normal growth and development, particularly of the brain. This study aimed to carry out a comprehensive assessment of the iodine status of New Zealand schoolchildren using a range of biochemical indices suitable for...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-31
更新日期:2012-05-08 00:00:00