Abstract:
BACKGROUND:Previous studies suggested that the abnormality of metabolism is a newly identified risk factor in HBV-related hepatocellular carcinoma (HCC). The association between metabolic factors and hepatocellular carcinoma (HCC) has not been clarified up to now. This study was conducted to investigate the prevalence of metabolic abnormalities in HCC and to probe the association between metabolic parameters and liver function as well, so as to evaluate the interactions between metabolism and the development of HBV-related HCC. METHODS:Totally 179 cases of HBV-related HCC, who were surgically treated and pathologically confirmed were enrolled. HBV carriers (n = 100) and healthy controls (n = 150) were recruited from routine physical examination during the same period. Body mass index (BMI) was obtained from medical documentation. All the metabolic-related parameters and liver function tests were determined with routine biochemical or immunological analytic methods. Malondialdehyde (MDA) and total antioxidant capacity(TAOC)were detected by chemical analytic methods. A stratified analysis was conducted according to BMI, glycated albumin (GA), free fatty acids (FFA), and the relationships between the metabolic-related parameters and liver functions were analyzed in HCC and control subjects. RESULTS:HCC group showed significantly high levels of mean BMI, serum glucose, low serum lipids levels than controls (P < 0.05). Acquired by stratified analysis, the higher the BMI, the higher level of insulin and homeostasis model assessment for insulin resistance (HOMA-IR) (P < 0.01) were found in HCC patients. Elevated level of MDA and γ-glutamyltransferase (GGT) were revealed in those with high serum FFA level for the first time. Strong associations between metabolic factors and liver function were shown in HCC (P < 0.05). Higher GA level was strongly associated with increased risk of cancer compared to healthy controls (OR = 9.87, 95% confidence interval: 1.86~52.29). Serum triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) levels were negative contributory factors for HCC (OR = 0.05, 95% confidence interval: 0.01~0.27 and OR = 0.32, 95% confidence interval, 0.11~0.95: respectively). CONCLUSIONS:Metabolic abnormalities are closely associated with the occurrence and development of HBV-related HCC. Oxidative stress and/or lipid peroxidation might be involved in the pathogenesis and acceleration of liver function impairments in HCC.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Zhao J,Zhao Y,Wang H,Gu X,Ji J,Gao Cdoi
10.1186/1475-2891-10-49subject
Has Abstractpub_date
2011-05-15 00:00:00pages
49issn
1475-2891pii
1475-2891-10-49journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Adolescence is a crucial period for development of dietary behaviors that continue into adulthood and influence the risk of chronic diseases later in life. The aim of this study was to determine the eating patterns of adolescents' and their compliance with the Food Guide Pyramid. METHODS:625 students, aged ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-9-67
更新日期:2010-12-19 00:00:00
abstract:BACKGROUND:The benefit of FV intake in old age is well documented. However, there is evidence that old people do not consume enough FV. The purpose of this study was to evaluate the effectiveness of a tailored nutrition intervention that aimed to increase the FV intake among elderly Iranians aged 60 and over. METHODS:...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2891-10-123
更新日期:2011-11-14 00:00:00
abstract:BACKGROUND:Cachexia is a state of involuntary weight loss common to many chronic diseases. Experimental data, showing that cachexia is related to the enhancement of acute phase response reaction, led to the new definition of cachexia that included, aside from the principal criterion of weight loss, other "minor criteri...
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pub_type: 杂志文章
doi:10.1186/1475-2891-12-6
更新日期:2013-01-07 00:00:00
abstract:BACKGROUND:Iodine intake is considered to be high in Japan due to regular seaweed consumption. Subgroups that do not have a traditional Japanese-style diet may consume insufficient amounts of iodine. METHOD:Three hundred and ninety apparently healthy adults (195 men and 195 women) aged 20 to 69 years from 20 areas thr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-015-0116-y
更新日期:2015-12-30 00:00:00
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journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-10-59
更新日期:2011-05-28 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12937-020-00569-1
更新日期:2020-07-25 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-5
更新日期:2012-01-17 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-015-0022-3
更新日期:2015-04-14 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,评审
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更新日期:2016-03-17 00:00:00
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journal_title:Nutrition journal
pub_type: 评论,信件
doi:10.1186/s12937-020-00620-1
更新日期:2020-09-11 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00626-9
更新日期:2020-10-30 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-42
更新日期:2013-04-08 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-015-0054-8
更新日期:2015-07-14 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-9
更新日期:2014-01-22 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-135
更新日期:2011-12-09 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0417-z
更新日期:2018-11-19 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0445-3
更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Due to the absence of a current and validated food frequency questionnaire (FFQ) for use in New Zealand adolescents, there is a need to develop one as a cost-effective way to assess adolescents' food patterns. This study aims to examine the test-retest reliability and relative validity of the New Zealand Ado...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-65
更新日期:2012-09-05 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0225-2
更新日期:2017-01-21 00:00:00
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pub_type: 杂志文章
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更新日期:2016-03-31 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-5-27
更新日期:2006-10-16 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2891-8-27
更新日期:2009-06-19 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0030-3
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND:Several studies have presented evidence suggesting that dairy consumption has beneficial effects on blood pressure (BP) in healthy subjects; however, only a few studies have examined this possibility in patients with established essential hypertension using ambulatory blood pressure monitoring. The objective...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-83
更新日期:2014-08-14 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-9-69
更新日期:2010-12-22 00:00:00
abstract:BACKGROUND:Antenatal vitamin D status may be associated with the risk of adverse pregnancy and neonatal outcomes; however, the benefits of vitamin D supplementation during pregnancy remain unknown. METHODS:We conducted a double-blind placebo-controlled randomized trial to evaluate the effect of high-dose prenatal 3rd ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-47
更新日期:2013-04-12 00:00:00
abstract:BACKGROUND:Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFAs) and better cognitive outcomes in older adults. To date, only two randomised, controlled trials have assessed the effect of n-3 LC PUFA supplementation on cognitive function in older cognitively he...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-117
更新日期:2011-10-20 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-017-0274-1
更新日期:2017-08-25 00:00:00
abstract:BACKGROUND:The 12-month Healthy Foods North intervention program was developed to improve diet among Inuit and Inuvialuit living in Arctic Canada and assess the impact of the intervention established for the communities. METHODS:A quasi-experimental study randomly selected men and women (≥19 years of age) in six remot...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-68
更新日期:2014-07-04 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-8-19
更新日期:2009-05-04 00:00:00