Abstract:
BACKGROUND:Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFAs) and better cognitive outcomes in older adults. To date, only two randomised, controlled trials have assessed the effect of n-3 LC PUFA supplementation on cognitive function in older cognitively healthy populations. Of these trials only one found a benefit, in the subgroup carrying the ApoE-ε4 allele. The benefits of n-3 LC PUFA supplementation on cognitive function in older normal populations thus still remain unclear. The main objective of the current study was to provide a comprehensive assessment of the potential of n-3 LC PUFAs to slow cognitive decline in normal elderly people, and included ApoE-ε4 allele carriage as a potential moderating factor. The detailed methodology of the trial is reported herein. METHODS:The study was a parallel, 18-month, randomised, double-blind, placebo-controlled intervention with assessment at baseline and repeated 6-monthly. Participants (N = 391, 53.7% female) aged 65-90 years, English-speaking and with normal cognitive function, were recruited from metropolitan Adelaide, South Australia. Participants in the intervention arm received capsules containing fish-oil at a daily dosage of 1720 mg of docosahexaenoic acid and 600 mg of eicosapentaenoic acid while the placebo arm received the equivalent amount of olive oil in their capsules. The primary outcome is rate of change in cognitive performance, as measured by latent variables for the cognitive constructs (encompassing Reasoning, Working Memory, Short-term Memory, Retrieval Fluency, Inhibition, Simple and Choice-Reaction Time, Perceptual Speed, Odd-man-out Reaction Time, Speed of Memory Scanning, and Psychomotor Speed) and assessed by latent growth curve modeling. Secondary outcomes are change in the Mini-mental State Examination, functional capacity and well-being (including health status, depression, mood, and self-report cognitive functioning), blood pressure, and biomarkers of n-3 LC PUFA status, glucose, lipid metabolism, inflammation, oxidative stress, and DNA damage. TRIAL REGISTRATION:Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12607000278437.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Danthiir V,Burns NR,Nettelbeck T,Wilson C,Wittert Gdoi
10.1186/1475-2891-10-117subject
Has Abstractpub_date
2011-10-20 00:00:00pages
117issn
1475-2891pii
1475-2891-10-117journal_volume
10pub_type
杂志文章,随机对照试验abstract::The benefits and risks of nutritional therapies in the prevention and management of infectious diseases in the developed world are reviewed. There is strong evidence that early enteral feeding of patients prevents infections in a variety of traumatic and surgical illnesses. There is, however, little support for simila...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-5-21
更新日期:2006-09-04 00:00:00
abstract:BACKGROUND & OBJECTIVE:Nutrition assessment enables early identification of malnourished patients and those at risk of malnutrition. To determine the prevalence of malnutrition, to analyze the correlation between short-form Mini Nutritional Assessment (MNA-SF) and Nutritional Risk Screening 2002 (NRS2002) with classica...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-015-0054-8
更新日期:2015-07-14 00:00:00
abstract::Most hepatocellular carcinoma (HCC) patients have complications, including cirrhosis and malnutrition. The efficacy of dietary supplementation with oral branched-chain amino acids (BCAAs) in HCC patients undergoing interventions has not been confirmed. Relevant publications on the efficacy and safety of oral BCAA supp...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12937-015-0056-6
更新日期:2015-07-09 00:00:00
abstract:BACKGROUND:Poor diet is thought to be a risk factor for many diseases, including age-related macular disease (ARMD), which is the leading cause of blind registration in those aged over 60 years in the developed world. The aims of this study were 1) to evaluate the dietary food intake of three subject groups: participan...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-3-16
更新日期:2004-09-28 00:00:00
abstract:BACKGROUND AND AIM:Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect of fenugreek intake o...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/1475-2891-13-7
更新日期:2014-01-18 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Dehydrated fruit and vegetable concentrates provide an accessible form of phytonutrient supplementation that may offer cardioprotective effects. This study assessed the effects of two blends of encapsulated juice powder concentrates (with and without added berry powders) on endothelial function...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-72
更新日期:2011-06-29 00:00:00
abstract:BACKGROUND:Psychosocial stress leads to altered neuroendocrine functions, such as serotonergic dysfunction, as well as alterations of the autonomic nervous system and the hypothalamic-pituitary-adrenal (HPA)-axis activity resulting in an imbalance between inhibitory and excitatory neurotransmitters. Poor dietary intake...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0030-3
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND:Many consumers avoid eating beans because they believe legume consumption will cause excessive intestinal gas or flatulence. An increasing body of research and the 2010 Dietary Guidelines for Americans supports the benefits of a plant-based diet, and legumes specifically, in the reduction of chronic disease ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-128
更新日期:2011-11-21 00:00:00
abstract:BACKGROUND:Inadequate protein intake is known to be deleterious in animals. Using WHO consensus documents for human nutrient requirements, the protein:energy ratio (P:E) of an adequate diet is > 5%. Cassava has a very low protein content. This study tested the hypothesis that Nigerian and Kenyan children consuming cass...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-9-9
更新日期:2010-02-26 00:00:00
abstract:BACKGROUND:Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown. OBJECTIVE:This study examined the effec...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-11-98
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Several studies have shown that cocoa and cocoa-containing foods have the potential to lower blood pressure and improve endothelial function. Most of the studies reporting the beneficial effects of dark chocolate on blood pressure have been short (≤ 4 weeks). The aim of the present 8-wks (weeks) study was to...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0075-3
更新日期:2015-08-22 00:00:00
abstract:BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hor...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-12-137
更新日期:2013-10-11 00:00:00
abstract:BACKGROUND:To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada. METHODS:A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-70
更新日期:2013-06-02 00:00:00
abstract:BACKGROUND:Vitamin D inadequacy is common among the elderly, especially within the Asian population. The vitamin D status among healthy adults in the elderly Chinese population was evaluated. METHODS:A total of 6014 healthy adults aged 60 years or older (2948 men, 3066 women) participated in this descriptive cross-sec...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0224-3
更新日期:2017-01-14 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human ...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0191-8
更新日期:2016-08-02 00:00:00
abstract:BACKGROUND:The benefit of FV intake in old age is well documented. However, there is evidence that old people do not consume enough FV. The purpose of this study was to evaluate the effectiveness of a tailored nutrition intervention that aimed to increase the FV intake among elderly Iranians aged 60 and over. METHODS:...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2891-10-123
更新日期:2011-11-14 00:00:00
abstract:BACKGROUND:Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences in dietary patterns and physical activity between MHO and metabolically unhealthy obesity (MUO). METHODS:Cross-sectional data of 9270 obese individuals (30-6...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0319-0
更新日期:2018-02-12 00:00:00
abstract:BACKGROUND:Fish consumption and intake of omega-3 fatty acids from fish are associated with a lower risk of cardiovascular disease. However, a prospective study from northern Sweden showed that high consumption of fish is associated with an increased risk of stroke in men, but not in women. The current study aimed to d...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-101
更新日期:2012-12-04 00:00:00
abstract:OBJECTIVES:To determine the effects of isoflavones (soy phyto-estrogens) on serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride (TG). METHODS:We searched electronic databases and included randomized trials with isoflavones interventions i...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-2-15
更新日期:2003-11-19 00:00:00
abstract:BACKGROUND:Comprehensive assessment of dietary intakes of foods and nutrients in Filipino adults are lacking. This study evaluated energy and nutrient intakes and food sources of key nutrients consumed by Filipino adults. METHODS:The participants were from the 2013 National Nutrition Survey wherein food intake of youn...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0481-z
更新日期:2019-10-10 00:00:00
abstract::Public health policies, including in Europe, are considering measures and recommendations to limit the intake of added or free sugars. For such policies to be efficient and monitored, a precise knowledge of the current situation regarding sugar intake in Europe is needed. This review summarizes published or re-analyze...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0225-2
更新日期:2017-01-21 00:00:00
abstract:INTRODUCTION:Cinnamon is currently marketed as a remedy for obesity, glucose intolerance, diabetes mellitus and dyslipidaemia. Integrative medicine is a new concept that combines conventional treatment with evidence-based complementary therapies. AIM:The aim of this review is to critically evaluate the experimental ev...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-015-0098-9
更新日期:2015-10-16 00:00:00
abstract:BACKGROUND:Several studies have presented evidence suggesting that dairy consumption has beneficial effects on blood pressure (BP) in healthy subjects; however, only a few studies have examined this possibility in patients with established essential hypertension using ambulatory blood pressure monitoring. The objective...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-83
更新日期:2014-08-14 00:00:00
abstract:BACKGROUND:Our previous studies demonstrated that dietary supplementation with milk fat globule membrane (MFGM) combined with habitual exercise improved muscle strength by stimulating neuromuscular development in mice. This study aimed to demonstrate the beneficial effects of dietary MFGM supplementation plus regular e...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0073-5
更新日期:2015-08-25 00:00:00
abstract:BACKGROUND:Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri E®) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-37
更新日期:2011-04-23 00:00:00
abstract:OBJECTIVE:Large preloads of protein and fat have been shown to lower glucose after a carbohydrate-rich meal in people with type 2 diabetes but add a considerable energy burden. Low calorie preloads [<5% of daily energy intake] have been tested in this study in people with prediabetes and with type 2 diabetes. RESEARCH...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-103
更新日期:2014-10-25 00:00:00
abstract:BACKGROUND:Based on data obtained from pregnant women who participated in the Mothers and Children's Environmental Health (MOCEH) study in South Korea, we aimed to determine whether maternal intake of fruits and vegetables or vitamin C is associated with fetal and infant growth. METHODS:A total of 1138 Korean pregnant...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究
doi:10.1186/s12937-018-0410-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:The cardiovascular and other health benefits and potential harms of protein and micronutrient deficiency of vegetarian diets continue to be debated. METHODS:Study participants included urban migrants, their rural siblings and urban residents (n = 6555, mean age - 40.9 yrs) of the Indian Migration Study from...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-55
更新日期:2014-06-04 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Adequate nutrient intakes among women of reproductive age (WRA) are important determinants of maternal, neonatal and child health outcomes. However, data on dietary intake for WRA in Vietnam are lacking. This paper aimed to examine the adequacy and determinants of energy and macronutrient inta...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2891-12-126
更新日期:2013-09-12 00:00:00
abstract:BACKGROUND:Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China. The aim of this study was to assess the iodine status in vulnerable groups from different geogr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-0525-4
更新日期:2020-01-21 00:00:00