The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older ad

Abstract:

BACKGROUND:Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFAs) and better cognitive outcomes in older adults. To date, only two randomised, controlled trials have assessed the effect of n-3 LC PUFA supplementation on cognitive function in older cognitively healthy populations. Of these trials only one found a benefit, in the subgroup carrying the ApoE-ε4 allele. The benefits of n-3 LC PUFA supplementation on cognitive function in older normal populations thus still remain unclear. The main objective of the current study was to provide a comprehensive assessment of the potential of n-3 LC PUFAs to slow cognitive decline in normal elderly people, and included ApoE-ε4 allele carriage as a potential moderating factor. The detailed methodology of the trial is reported herein. METHODS:The study was a parallel, 18-month, randomised, double-blind, placebo-controlled intervention with assessment at baseline and repeated 6-monthly. Participants (N = 391, 53.7% female) aged 65-90 years, English-speaking and with normal cognitive function, were recruited from metropolitan Adelaide, South Australia. Participants in the intervention arm received capsules containing fish-oil at a daily dosage of 1720 mg of docosahexaenoic acid and 600 mg of eicosapentaenoic acid while the placebo arm received the equivalent amount of olive oil in their capsules. The primary outcome is rate of change in cognitive performance, as measured by latent variables for the cognitive constructs (encompassing Reasoning, Working Memory, Short-term Memory, Retrieval Fluency, Inhibition, Simple and Choice-Reaction Time, Perceptual Speed, Odd-man-out Reaction Time, Speed of Memory Scanning, and Psychomotor Speed) and assessed by latent growth curve modeling. Secondary outcomes are change in the Mini-mental State Examination, functional capacity and well-being (including health status, depression, mood, and self-report cognitive functioning), blood pressure, and biomarkers of n-3 LC PUFA status, glucose, lipid metabolism, inflammation, oxidative stress, and DNA damage. TRIAL REGISTRATION:Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12607000278437.

journal_name

Nutr J

journal_title

Nutrition journal

authors

Danthiir V,Burns NR,Nettelbeck T,Wilson C,Wittert G

doi

10.1186/1475-2891-10-117

subject

Has Abstract

pub_date

2011-10-20 00:00:00

pages

117

issn

1475-2891

pii

1475-2891-10-117

journal_volume

10

pub_type

杂志文章,随机对照试验
  • Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation.

    abstract:BACKGROUND:Tocotrienols (T3) and tocopherols (T), both members of the natural vitamin E family have unique biological functions in humans. T3 are detected in circulating human plasma and lipoproteins, although at concentrations significantly lower than α-tocopherol (α-T). T3, especially α-T3 is known to be neuropotecti...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-11-5

    authors: Fairus S,Nor RM,Cheng HM,Sundram K

    更新日期:2012-01-17 00:00:00

  • Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water.

    abstract:BACKGROUND:Limited data exist on the contribution of dietary sources of arsenic to an individual's total exposure, particularly in populations with exposure via drinking water. Here, the association between diet and toenail arsenic concentrations (a long-term biomarker of exposure) was evaluated for individuals with me...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-12-149

    authors: Cottingham KL,Karimi R,Gruber JF,Zens MS,Sayarath V,Folt CL,Punshon T,Morris JS,Karagas MR

    更新日期:2013-11-16 00:00:00

  • Validity and reproducibility of an interviewer-administered food frequency questionnaire for healthy French-Canadian men and women.

    abstract:OBJECTIVE:To evaluate the validity (study 1) and the reproducibility (study 2) of an interviewer-administered food frequency questionnaire (FFQ). METHOD:The FFQ was designed at Laval University and contains 91 items and 33 subquestions. STUDY 1: The FFQ was compared against a 3-day food record (2 week-days and 1 weeke...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-3-13

    authors: Goulet J,Nadeau G,Lapointe A,Lamarche B,Lemieux S

    更新日期:2004-09-13 00:00:00

  • Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative.

    abstract:BACKGROUND:The extent to which psychosocial and diet behavior factors affect dietary self-report remains unclear. We examine the contribution of these factors to measurement error of self-report. METHODS:In 450 postmenopausal women in the Women's Health Initiative Observational Study doubly labeled water and urinary n...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-12-63

    authors: Mossavar-Rahmani Y,Tinker LF,Huang Y,Neuhouser ML,McCann SE,Seguin RA,Vitolins MZ,Curb JD,Prentice RL

    更新日期:2013-05-16 00:00:00

  • Fruit and vegetables intake among elderly Iranians: a theory-based interventional study using the five-a-day program.

    abstract:BACKGROUND:The benefit of FV intake in old age is well documented. However, there is evidence that old people do not consume enough FV. The purpose of this study was to evaluate the effectiveness of a tailored nutrition intervention that aimed to increase the FV intake among elderly Iranians aged 60 and over. METHODS:...

    journal_title:Nutrition journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1475-2891-10-123

    authors: Salehi L,Mohammad K,Montazeri A

    更新日期:2011-11-14 00:00:00

  • Response to important considerations when assessing the effect of essential fatty acids on cognitive performance.

    abstract::In this letter, we respond to the comments raised by Visaria et al. in their letter to the editor about the publication "Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES) 2011-2014". We have further adjusted for s...

    journal_title:Nutrition journal

    pub_type: 评论,信件

    doi:10.1186/s12937-020-00620-1

    authors: Dong X,Zhang D

    更新日期:2020-09-11 00:00:00

  • Diet and lifestyle factors associated with fish consumption in men and women: a study of whether gender differences can result in gender-specific confounding.

    abstract:BACKGROUND:Fish consumption and intake of omega-3 fatty acids from fish are associated with a lower risk of cardiovascular disease. However, a prospective study from northern Sweden showed that high consumption of fish is associated with an increased risk of stroke in men, but not in women. The current study aimed to d...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-11-101

    authors: Wennberg M,Tornevi A,Johansson I,Hörnell A,Norberg M,Bergdahl IA

    更新日期:2012-12-04 00:00:00

  • Dairy intake revisited - associations between dairy intake and lifestyle related cardio-metabolic risk factors in a high milk consuming population.

    abstract:BACKGROUND:The association between milk and dairy intake and the incidence of cardiometabolic diseases, cancer and mortality has been evaluated in many studies, but these studies have had conflicting results with no clear conclusion on causal or confounding associations. The present study aims to further address this a...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-018-0418-y

    authors: Johansson I,Nilsson LM,Esberg A,Jansson JH,Winkvist A

    更新日期:2018-11-22 00:00:00

  • The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial.

    abstract:BACKGROUND:Recommendations for daily dietary vegetable intake were increased in the 2005 USDA Dietary Guidelines as consumption of a diet rich in vegetables has been associated with lower risk of certain chronic health disorders including cardiovascular disease. However, vegetable consumption in the United States has d...

    journal_title:Nutrition journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1475-2891-9-38

    authors: Shenoy SF,Kazaks AG,Holt RR,Chen HJ,Winters BL,Khoo CS,Poston WS,Haddock CK,Reeves RS,Foreyt JP,Gershwin ME,Keen CL

    更新日期:2010-09-17 00:00:00

  • A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan-oligosaccharides enriched bread in healthy volunteers.

    abstract:BACKGROUND:Prebiotics are food ingredients, usually non-digestible oligosaccharides, that are selectively fermented by populations of beneficial gut bacteria. Endoxylanases, altering the naturally present cereal arabinoxylans, are commonly used in the bread industry to improve dough and bread characteristics. Recently,...

    journal_title:Nutrition journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1186/1475-2891-11-36

    authors: Walton GE,Lu C,Trogh I,Arnaut F,Gibson GR

    更新日期:2012-06-01 00:00:00

  • Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population.

    abstract:BACKGROUND:Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and early mortality. Excessive shortening of telomere is a marker of accelerated aging and can be influenced by oxidative stress and nutritional deficiency. Plasma n6:n3 polyunsaturated fatty acid...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-00626-9

    authors: Chang X,Dorajoo R,Sun Y,Wang L,Ong CN,Liu J,Khor CC,Yuan JM,Koh WP,Friedlander Y,Heng CK

    更新日期:2020-10-30 00:00:00

  • Inadequate physician knowledge of the effects of diet on blood lipids and lipoproteins.

    abstract:BACKGROUND:To assess the nutrition knowledge of physicians on the basic effects of diet on blood lipids and lipoproteins. METHODS:Anonymous mailed dietary knowledge surveys to 6000 randomly selected physicians in the United States licensed in either Internal Medicine or Cardiology. RESULTS:Response rate: 16% (n = 639...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-2-19

    authors: Flynn M,Sciamanna C,Vigilante K

    更新日期:2003-12-01 00:00:00

  • Placebo-controlled dietary intervention of stress-induced neurovegetative disorders with a specific amino acid composition: a pilot-study.

    abstract:BACKGROUND:Psychosocial stress leads to altered neuroendocrine functions, such as serotonergic dysfunction, as well as alterations of the autonomic nervous system and the hypothalamic-pituitary-adrenal (HPA)-axis activity resulting in an imbalance between inhibitory and excitatory neurotransmitters. Poor dietary intake...

    journal_title:Nutrition journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12937-015-0030-3

    authors: Chaborski K,Bitterlich N,Alteheld B,Parsi E,Metzner C

    更新日期:2015-05-06 00:00:00

  • Socioeconomic gradient in consumption of whole fruit and 100% fruit juice among US children and adults.

    abstract:BACKGROUND:The consumption of fruit is generally associated with better health, but also higher socioeconomic status (SES). Most previous studies evaluating consumption of fruits have not separated 100% fruit juice and whole fruit, which may conceal interesting patterns in consumption. OBJECTIVE:To estimate demographi...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-14-3

    authors: Drewnowski A,Rehm CD

    更新日期:2015-01-05 00:00:00

  • Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study.

    abstract:BACKGROUND:Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults;...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-00575-3

    authors: D'Amico D,Parrott MD,Greenwood CE,Ferland G,Gaudreau P,Belleville S,Laurin D,Anderson ND,Kergoat MJ,Morais JA,Presse N,Fiocco AJ

    更新日期:2020-06-20 00:00:00

  • Feasibility of a commercial smartphone application for dietary assessment in epidemiological research and comparison with 24-h dietary recalls.

    abstract:BACKGROUND:Dietary assessment methods that can provide high quality data while limiting participant burden and resource requirements in epidemiological research are highly sought after and continue to evolve. The use of mobile phone technology in research has increased rapidly over the last decade and offers multiple a...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-018-0315-4

    authors: Ambrosini GL,Hurworth M,Giglia R,Trapp G,Strauss P

    更新日期:2018-01-09 00:00:00

  • Do dietary intakes influence the rate of decline in anti-Mullerian hormone among eumenorrheic women? A population-based prospective investigation.

    abstract:BACKGROUND:Dietary intakes are suggested to affect age at menopause but associations between dietary factors and ovarian reserve reduction have not yet been investigated. We aimed to examine dietary intakes in relation to the rate of decline in anti-Mullerian hormone (AMH), an indicator of ovarian reserve, in a general...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-019-0508-5

    authors: Moslehi N,Mirmiran P,Azizi F,Tehrani FR

    更新日期:2019-12-02 00:00:00

  • Impact of menaquinone-4 supplementation on coronary artery calcification and arterial stiffness: an open label single arm study.

    abstract:BACKGROUND:Dietary intake of vitamin K has been reported to reduce coronary artery calcification (CAC) and cardiovascular events. However, it is unknown whether supplemental menaquinone (MK)-4 can reduce CAC or arterial stiffness. To study the effect of MK-4 supplementation on CAC and brachial ankle pulse wave velocity...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-016-0175-8

    authors: Ikari Y,Torii S,Shioi A,Okano T

    更新日期:2016-05-12 00:00:00

  • Beyond clinical food prescriptions and mobile markets: parent views on the role of a healthcare institution in increasing healthy eating in food insecure families.

    abstract:BACKGROUND:Children in food-insecure families face increased barriers to meeting recommendations for fruit and vegetable consumption. Hospitals and pediatric healthcare institutions have attempted to alleviate food-insecurity through various internal programs like food prescriptions, yet little evidence for these progr...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-00616-x

    authors: DeWit EL,Meissen-Sebelius EM,Shook RP,Pina KA,De Miranda ED,Summar MJ,Hurley EA

    更新日期:2020-09-09 00:00:00

  • Effects of isoflavones (soy phyto-estrogens) on serum lipids: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVES:To determine the effects of isoflavones (soy phyto-estrogens) on serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride (TG). METHODS:We searched electronic databases and included randomized trials with isoflavones interventions i...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-2-15

    authors: Yeung J,Yu TF

    更新日期:2003-11-19 00:00:00

  • Sex and gender differences in nutrition research: considerations with the transgender and gender nonconforming population.

    abstract::A sex- and gender-informed approach to study design, analysis and reporting has particular relevance to the transgender and gender nonconforming population (TGNC) where sex and gender identity differ. Notable research gaps persist related to dietary intake, validity and reliability of nutrition assessment methods, and...

    journal_title:Nutrition journal

    pub_type: 信件

    doi:10.1186/s12937-021-00662-z

    authors: Linsenmeyer W,Waters J

    更新日期:2021-01-15 00:00:00

  • Evaluation of antiaggregatory activity of flavonoid aglycone series.

    abstract:BACKGROUND:Among natural compounds, present in every day diet, flavonoids have shown beneficial effect in prevention of cardiovascular diseases that can be attributed, at least partially to the described antiaggregatory activity i.e. antiplatelet effects of flavonoids. Due to the ever increasing pharmacological interes...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-10-73

    authors: Bojić M,Debeljak Z,Tomičić M,Medić-Šarić M,Tomić S

    更新日期:2011-07-11 00:00:00

  • The effects of spinach-derived thylakoid supplementation in combination with calorie restriction on anthropometric parameters and metabolic profiles in obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical tri

    abstract:BACKGROUND:There is a promising outlook regarding the potential effect of spinach-derived thylakoids in the management of obesity and its associated metabolic disturbances. This research aimed to evaluate the effects of spinach-derived thylakoids supplementation combined with a calorie-restricted diet on anthropometric...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-00601-4

    authors: Tabrizi FPF,Farhangi MA,Vaezi M,Hemmati S

    更新日期:2020-08-11 00:00:00

  • Dietary patterns and chronic kidney disease risk: a systematic review and updated meta-analysis of observational studies.

    abstract:BACKGROUND:A number of studies have reported the association between dietary patterns and the risk of chronic kidney disease (CKD), however a consistent perspective hasn't been established to date. Herein, we conducted this systematic review and meta-analysis of observational studies to assess the association between d...

    journal_title:Nutrition journal

    pub_type: 杂志文章,评审

    doi:10.1186/s12937-020-00661-6

    authors: He LQ,Wu XH,Huang YQ,Zhang XY,Shu L

    更新日期:2021-01-08 00:00:00

  • Seaweed intake and blood pressure levels in healthy pre-school Japanese children.

    abstract:BACKGROUND:Few studies have examined whether dietary factors might affect blood pressure in children. We purposed to investigate whether seaweed intake is associated with blood pressure level among Japanese preschool children. METHODS:The design of the study was cross-sectional and it was conducted in autumn 2006. Sub...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-10-83

    authors: Wada K,Nakamura K,Tamai Y,Tsuji M,Sahashi Y,Watanabe K,Ohtsuchi S,Yamamoto K,Ando K,Nagata C

    更新日期:2011-08-10 00:00:00

  • Efficacy of a long-term home parenteral nutrition regimen containing fish oil-derived n-3 polyunsaturated fatty acids: a single-centre, randomized, double blind study.

    abstract:BACKGROUND:Data on the use of lipid emulsions containing fish-oil (FO) derived n-3 polyunsaturated fatty acids (n-3 PUFAs) in addition to medium- and long-chain triglycerides (MCT/LCT) for long-term home parenteral nutrition (HPN) are limited. This study aimed to compare HPN regimens containing either MCT/LCT/FO-derive...

    journal_title:Nutrition journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12937-018-0419-x

    authors: Bohnert H,Maurer M,Calder PC,Pratschke J,Thul P,Müller V

    更新日期:2018-11-30 00:00:00

  • Use of plant stanol ester margarine among persons with and without cardiovascular disease: early phases of the adoption of a functional food in Finland.

    abstract:BACKGROUND:The plant stanol ester margarine Benecol is a functional food that has been shown to lower effectively serum total and LDL-cholesterol. The purpose of this post-marketing study is to characterize users of plant stanol ester margarine with and without cardiovascular disease. METHODS:A cohort of plant stanol ...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-4-20

    authors: Simojoki M,Luoto R,Uutela A,Rita H,Boice JD Jr,McLaughlin JK,Puska P

    更新日期:2005-06-01 00:00:00

  • The consumption of unhealthy foods by Brazilian children is influenced by their mother's educational level.

    abstract:OBJECTIVE:To evaluate the association between the consumption of unhealthy foods in children under one year and the education level of the mothers, data obtained from participants of the II Survey on the prevalence of breastfeeding in the Brazilian capitals and the Federal District in 2008 was analyzed. METHODS:During...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-13-33

    authors: Saldiva SR,Venancio SI,de Santana AC,da Silva Castro AL,Escuder MM,Giugliani ER

    更新日期:2014-04-03 00:00:00

  • The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials.

    abstract:INTRODUCTION:Cinnamon is currently marketed as a remedy for obesity, glucose intolerance, diabetes mellitus and dyslipidaemia. Integrative medicine is a new concept that combines conventional treatment with evidence-based complementary therapies. AIM:The aim of this review is to critically evaluate the experimental ev...

    journal_title:Nutrition journal

    pub_type: 杂志文章,评审

    doi:10.1186/s12937-015-0098-9

    authors: Medagama AB

    更新日期:2015-10-16 00:00:00

  • Pairing nuts and dried fruit for cardiometabolic health.

    abstract::Certain dietary patterns, in which fruits and nuts are featured prominently, reduce risk of diabetes and cardiovascular disease. However, estimated fruit consumption historically in the U.S. has been lower than recommendations. Dried fruit intake is even lower with only about 6.9 % of the adult population reporting an...

    journal_title:Nutrition journal

    pub_type: 杂志文章,评审

    doi:10.1186/s12937-016-0142-4

    authors: Carughi A,Feeney MJ,Kris-Etherton P,Fulgoni V 3rd,Kendall CW,Bulló M,Webb D

    更新日期:2016-03-05 00:00:00