Abstract:
BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone mineral density were measured in 23 of the original study subjects, aged 60-82 years who had consumed bread buns (100 g) fortified with 320 mg elemental calcium and 125 μg (5,000 IU) vitamin D3 daily for one year. RESULTS:At the end of the 1-year supplementation phase (receiving vitamin D3 fortified bread daily), mean (SD) serum 25(OH)D was 127.3 ± 37.8 nmol/L (baseline for this follow-up). At 1-year follow-up, the serum 25(OH)D was 64.9 ± 24.8 nmol/L (p = 0.001, vs. baseline); and at 3-year follow-up it was 28.0 ± 15.0 nmol/L (p = 0.001 vs. baseline). Serum PTH was 18.8 ± 15.6 pg/ml at baseline while at Year 3 it was 48.4 ± 18.4 pg/ml (p = 0.001 vs. baseline). Lumbar spine BMD did not change from baseline to Year 3. However, by Year 3, hip BMD had decreased (0.927 ± 0.130 g/cm² vs. 0.907 ± 0.121 g/cm², p = 0.024). CONCLUSION:Vitamin D nutritional status exhibits a long half-life in the body, and a true steady-state plateau may not even be reached 1 year after a discontinuation in dose. Furthermore, once the need for vitamin D has been established, based on a low baseline serum 25(OH)D concentrations, the appropriate action is to maintain corrective vitamin D supplementation over the long term.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Mocanu V,Vieth Rdoi
10.1186/1475-2891-12-137subject
Has Abstractpub_date
2013-10-11 00:00:00pages
137issn
1475-2891pii
1475-2891-12-137journal_volume
12pub_type
临床试验,杂志文章abstract:BACKGROUND:Consumption of nuts improves cardio-metabolic risk factors in clinical trials and relates to lower risk of cardiovascular disease (CVD) in prospective observational studies. However, there has not been an adequately powered randomized controlled trial to test if nuts supplementation actually reduces incident...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00660-7
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:High level of serum cholesterol is considered to be a major risk factor for cardiovascular disease (CVD). A double-blinded, randomized, placebo-controlled trial was performed to test the hypothesis that a daily intake of Chlorella may improve serum lipid profile through enhancement of serum carotenoid concen...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-57
更新日期:2014-06-11 00:00:00
abstract:BACKGROUND:Low diet quality and depression symptoms are independently associated with poor glycemic control in subjects with type 2 diabetes (T2D); however, the relationship between them is unclear. The aim of this study was to determine the association between diet quality and symptoms of depression among Cuban-Americ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-135
更新日期:2011-12-09 00:00:00
abstract:BACKGROUND:Constipation is a common occurrence in formula-fed infants. The aim of this preliminary study was to evaluate the impact of a formula with high levels of lactose and magnesium, in compliance with the official regulations, on stool water content, as well as a parental assessment of constipation. MATERIALS AN...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-55
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:In order to rapidly assess nutrient intake, Food Frequency Questionnaires (FFQ) have been developed and proven to be reliable for quick, user friendly analysis in adults. However, the accuracy of these questionnaires in children has been studied to a limited extent. The aim of this study was to compare the d...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-6-24
更新日期:2007-09-19 00:00:00
abstract:BACKGROUND AND AIM:Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect of fenugreek intake o...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/1475-2891-13-7
更新日期:2014-01-18 00:00:00
abstract:BACKGROUND:Our previous studies demonstrated that dietary supplementation with milk fat globule membrane (MFGM) combined with habitual exercise improved muscle strength by stimulating neuromuscular development in mice. This study aimed to demonstrate the beneficial effects of dietary MFGM supplementation plus regular e...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0073-5
更新日期:2015-08-25 00:00:00
abstract:BACKGROUND:The increase in the burden of chronic diseases linked to the nutrition transition and associated dietary and lifestyle changes is of growing concern in south and east Mediterranean countries and adolescents are at the forefront of these changes. This study assessed dietary intake and association with socio-e...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-38
更新日期:2011-04-24 00:00:00
abstract:BACKGROUND:In young men, unhealthy lifestyle behaviours can be detrimental to their physical and/or mental health and set them on a negative health trajectory into adulthood. Despite this, there is a lack of evidence to guide development of effective health behaviour change interventions for young men. This study asses...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-017-0227-8
更新日期:2017-01-13 00:00:00
abstract::The composition and function of human milk is unique and gives a basis for the development of modern artificial milk formulas that can provide an appropriate substitute for non-breastfed infants. Although human milk is not fully substitutable, modern milk formulas are attempting to mimic human milk and partially subst...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0145-1
更新日期:2016-03-17 00:00:00
abstract:BACKGROUND:The extent to which psychosocial and diet behavior factors affect dietary self-report remains unclear. We examine the contribution of these factors to measurement error of self-report. METHODS:In 450 postmenopausal women in the Women's Health Initiative Observational Study doubly labeled water and urinary n...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-63
更新日期:2013-05-16 00:00:00
abstract::Most hepatocellular carcinoma (HCC) patients have complications, including cirrhosis and malnutrition. The efficacy of dietary supplementation with oral branched-chain amino acids (BCAAs) in HCC patients undergoing interventions has not been confirmed. Relevant publications on the efficacy and safety of oral BCAA supp...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12937-015-0056-6
更新日期:2015-07-09 00:00:00
abstract:BACKGROUND:Children in food-insecure families face increased barriers to meeting recommendations for fruit and vegetable consumption. Hospitals and pediatric healthcare institutions have attempted to alleviate food-insecurity through various internal programs like food prescriptions, yet little evidence for these progr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00616-x
更新日期:2020-09-09 00:00:00
abstract:BACKGROUND:Medical nutrition therapy is recognized as an important treatment option in type 2 diabetes. Most guidelines recommend eating a diet with a high intake of fiber-rich food including fruit. This is based on the many positive effects of fruit on human health. However some health professionals have concerns that...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-29
更新日期:2013-03-05 00:00:00
abstract:BACKGROUND:The 12-month Healthy Foods North intervention program was developed to improve diet among Inuit and Inuvialuit living in Arctic Canada and assess the impact of the intervention established for the communities. METHODS:A quasi-experimental study randomly selected men and women (≥19 years of age) in six remot...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-68
更新日期:2014-07-04 00:00:00
abstract:BACKGROUND:Dietary fibre food intake is related to a reduced risk of developing diabetes mellitus. However, the mechanism of this effect is still not clear. The aim of this study was to evaluate the effect of commercial fibre cereals on the rate of gastric emptying, postprandial glucose response and satiety in healthy ...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1475-2891-6-22
更新日期:2007-09-17 00:00:00
abstract:BACKGROUND:There is a promising outlook regarding the potential effect of spinach-derived thylakoids in the management of obesity and its associated metabolic disturbances. This research aimed to evaluate the effects of spinach-derived thylakoids supplementation combined with a calorie-restricted diet on anthropometric...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00601-4
更新日期:2020-08-11 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the timing of introduction of complementary (solid) foods among infants in South Western Sydney, Australia, and describe the maternal and infant characteristics associated with very early introduction of solids. METHODS:Mother-infant dyads (n = 1035) were recruited in...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-0528-1
更新日期:2020-02-18 00:00:00
abstract:BACKGROUND:This study was designed to determine the glycemic indices of five commonly used varieties of dates in healthy subjects and their effects on postprandial glucose excursions in individuals with type 2 diabetes mellitus. METHODS:Composition analysis was carried out for five types of dates (Tamer stage). The we...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-10-59
更新日期:2011-05-28 00:00:00
abstract:BACKGROUND/OBJECTIVES:Breast milk contains lutein derived from the mother's diet. This carotenoid is currently not added to infant formula, which has a small and variable lutein content from innate ingredients. This study was conducted to compare the growth of infants fed lutein-fortified infant formula with that of in...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-9-22
更新日期:2010-05-21 00:00:00
abstract:BACKGROUND:Multiple specialized nutritious food options are programmed for supplementation in humanitarian and development settings. However, comparative cost-effectiveness evidence is lacking, let alone incorporation of perspectives from uncompensated stakeholders. A Burkina Faso trial evaluated the cost-effectiveness...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00535-x
更新日期:2020-02-27 00:00:00
abstract::A sex- and gender-informed approach to study design, analysis and reporting has particular relevance to the transgender and gender nonconforming population (TGNC) where sex and gender identity differ. Notable research gaps persist related to dietary intake, validity and reliability of nutrition assessment methods, and...
journal_title:Nutrition journal
pub_type: 信件
doi:10.1186/s12937-021-00662-z
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Despite the health benefits of regular vegetable and legume consumption, on average Australians are consuming only half of the recommended daily intake. The reasons for this low consumption are complex, and are particularly driven by societal shifts towards convenient and ready-to-eat meal options. It is cur...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0414-2
更新日期:2018-11-09 00:00:00
abstract:BACKGROUND:Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China. The aim of this study was to assess the iodine status in vulnerable groups from different geogr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-0525-4
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Inadequate protein intake is known to be deleterious in animals. Using WHO consensus documents for human nutrient requirements, the protein:energy ratio (P:E) of an adequate diet is > 5%. Cassava has a very low protein content. This study tested the hypothesis that Nigerian and Kenyan children consuming cass...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-9-9
更新日期:2010-02-26 00:00:00
abstract:BACKGROUND:Poor diet is thought to be a risk factor for many diseases, including age-related macular disease (ARMD), which is the leading cause of blind registration in those aged over 60 years in the developed world. The aims of this study were 1) to evaluate the dietary food intake of three subject groups: participan...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-3-16
更新日期:2004-09-28 00:00:00
abstract:BACKGROUND:Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown. OBJECTIVE:This study examined the effec...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-11-98
更新日期:2012-11-21 00:00:00
abstract::Certain dietary patterns, in which fruits and nuts are featured prominently, reduce risk of diabetes and cardiovascular disease. However, estimated fruit consumption historically in the U.S. has been lower than recommendations. Dried fruit intake is even lower with only about 6.9 % of the adult population reporting an...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0142-4
更新日期:2016-03-05 00:00:00
abstract:BACKGROUND:Recommendations for daily dietary vegetable intake were increased in the 2005 USDA Dietary Guidelines as consumption of a diet rich in vegetables has been associated with lower risk of certain chronic health disorders including cardiovascular disease. However, vegetable consumption in the United States has d...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-9-38
更新日期:2010-09-17 00:00:00
abstract:BACKGROUND:Information regarding dietary patterns associated with prediabetes in the Chinese population is lacking. The objective of the present study was to explore the association between major dietary patterns and the risk of prediabetes in a middle-aged Chinese population. METHODS:A total of 1761 participants (age...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00593-1
更新日期:2020-07-30 00:00:00