Abstract:
BACKGROUND:Multiple specialized nutritious food options are programmed for supplementation in humanitarian and development settings. However, comparative cost-effectiveness evidence is lacking, let alone incorporation of perspectives from uncompensated stakeholders. A Burkina Faso trial evaluated the cost-effectiveness of Corn Soy Blend Plus w/ oil (CSB+ w/oil, reference arm), Corn Soy Whey Blend w/oil (CSWB w/oil), Super Cereal Plus (SC+), and Ready-to-Use Supplementary Food (RUSF) in reducing stunting and wasting among children 6-23 months old. This paper presents cost-effectiveness findings from multiple stakeholders' perspectives, including caregivers and program volunteers. METHODS:An activity-based costing with ingredients approach was used to summarize cost of the 18-month-long blanket supplementary feeding for each enrolled child (in 2018 USD). Time data were collected using self-reported and observational instruments. Cost-effectiveness relative to CSB+ w/oil assessed incremental cost per enrolled child against incremental outcomes: prevalence of stunting at 23 months of age and number of months of wasting. Two combined perspectives were compared: program (donor, implementer, and volunteer) versus program and caregiver (adding caregiver). RESULTS:A total of 6112 children were enrolled. While similar effectiveness was found in three arms (CSWB w/oil was less effective), costs differed. Product cost and caregiver time to prepare study foods were major drivers of cross-arm cost differences from the respective combined perspective. The two major drivers were used to construct uncertainty ranges of cost per enrolled child from program and caregiver perspective: $317 ($279- $355) in CSB+ w/oil, $350 ($327- $373) in CSWB w/oil, $387 ($371- $403) in RUSF, and $434 ($365- $503) in SC+. Cost from program and caregiver perspective was a substantial increase from program perspective. CSB+ w/oil was most cost-effective in reducing stunting and wasting, and this main finding was robust to changing perspectives and all corresponding sensitivity analyses when uncompensated time was valued at minimum wage ($0.36/h). The break-even point for uncompensated time valuation is >$0.84/h, where RUSF became the most cost-effective from the program and caregiver perspective. Relative cost-effectiveness rankings among the other three arms depended on choice of perspectives, and were sensitive to values assigned to product cost, international freight cost, opportunity cost of time, and outcomes of a hypothetical control. Volunteer opportunity cost did not affect arm comparisons, but lack of compensation resulted in negative financial consequences for caregivers. CONCLUSIONS:Evaluating cost-effectiveness by incorporating uncompensated stakeholders provided crucial implementation insights around nutrition products and programming. TRIAL REGISTRATION:Trial registration number: NCT02071563. Name of registry: ClinicalTrials.gov URL of registry: https://clinicaltrials.gov/ct2/show/NCT02071563?type=Intr&cond=Malnutrition&cntry=BF&draw=2&rank=9 Date of registration: February 26, 2014. Date of enrollment of first participant: July 2014.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Shen Y,Cliffer IR,Suri DJ,Langlois BK,Vosti SA,Webb P,Rogers BLdoi
10.1186/s12937-020-00535-xsubject
Has Abstractpub_date
2020-02-27 00:00:00pages
20issue
1issn
1475-2891pii
10.1186/s12937-020-00535-xjournal_volume
19pub_type
杂志文章abstract:BACKGROUND AND AIM:Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect of fenugreek intake o...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/1475-2891-13-7
更新日期:2014-01-18 00:00:00
abstract:BACKGROUND:Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences in dietary patterns and physical activity between MHO and metabolically unhealthy obesity (MUO). METHODS:Cross-sectional data of 9270 obese individuals (30-6...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0319-0
更新日期:2018-02-12 00:00:00
abstract:BACKGROUND:Arterial stiffness is a component of vascular function and an established risk factor for cardiovascular disease. There is a lack of conclusive evidence on the effect of a meal rich in monounsaturated fat (MUFA) compared with an isoenergetic meal rich in saturated fat (SFA) on postprandial vascular function ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-93
更新日期:2013-07-10 00:00:00
abstract:BACKGROUND:The food frequency questionnaire (FFQ) is the most frequently used method to assess dietary intake in epidemiological studies evaluating diet-disease association. The objective of this study was to validate a FFQ for use among Lebanese adults by evaluating various facets of validity and reproducibility. MET...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00581-5
更新日期:2020-07-06 00:00:00
abstract:AIM:To study the association between the expression of H3K27me3 and ACat2 (a folate metabolic protein), in order to elucidate the protective mechanism of folic acid (FA) in neural tube defects (NTDs). METHODS:Eighteen female SD rats were randomly divided into normal, NTD and FA group. NTD group was induced by all-tran...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0212-7
更新日期:2016-11-03 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the timing of introduction of complementary (solid) foods among infants in South Western Sydney, Australia, and describe the maternal and infant characteristics associated with very early introduction of solids. METHODS:Mother-infant dyads (n = 1035) were recruited in...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-0528-1
更新日期:2020-02-18 00:00:00
abstract:BACKGROUND:There is a promising outlook regarding the potential effect of spinach-derived thylakoids in the management of obesity and its associated metabolic disturbances. This research aimed to evaluate the effects of spinach-derived thylakoids supplementation combined with a calorie-restricted diet on anthropometric...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00601-4
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Prebiotics are food ingredients, usually non-digestible oligosaccharides, that are selectively fermented by populations of beneficial gut bacteria. Endoxylanases, altering the naturally present cereal arabinoxylans, are commonly used in the bread industry to improve dough and bread characteristics. Recently,...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1475-2891-11-36
更新日期:2012-06-01 00:00:00
abstract::Added sugar regulations and recommendations have been proposed by policy makers around the world. With no universal definition, limited access to added sugar values in food products and no analytical difference from intrinsic sugars, added sugar recommendations present a unique challenge. Average added sugar intake by...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-015-0114-0
更新日期:2015-12-12 00:00:00
abstract:BACKGROUND:To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada. METHODS:A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-70
更新日期:2013-06-02 00:00:00
abstract:BACKGROUND:Aging is a process associated with physiological changes such as in body composition, energy expenditure and physical activity. Data on energy and nutrient intake adequacy among elderly is important for disease prevention, health maintenance and program development. METHODS:This descriptive cross-sectional ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-8-19
更新日期:2009-05-04 00:00:00
abstract:BACKGROUND:Obesity develops when energy intake continuously exceeds energy expenditure, causing a fundamental chronic energy imbalance. Societal and behavioural changes over the last decades are held responsible for the considerable increase in sedentary lifestyles and inappropriate dietary patterns. The role of dietar...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-6-26
更新日期:2007-09-21 00:00:00
abstract:BACKGROUND:We have recently reported that short-term (21-day) dietary modification in accordance with a stringent vegan diet (i.e., a Daniel Fast) lowers blood lipids as well as biomarkers of oxidative stress. However, this work only involved measurements obtained in a fasted state. In the present study, we determined ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-16
更新日期:2012-03-21 00:00:00
abstract:BACKGROUND:Few localized food frequency questionnaires (FFQ) have been developed and used in Chinese nutrition surveys despite China's large population and diverse dietary habits. METHOD:We analyzed data collected in two waves (six months apart) of the Shanghai Diet and Health Study in 2012-2013, from 1623 Shanghai re...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0454-2
更新日期:2019-05-23 00:00:00
abstract:BACKGROUND:Tocotrienols (T3) and tocopherols (T), both members of the natural vitamin E family have unique biological functions in humans. T3 are detected in circulating human plasma and lipoproteins, although at concentrations significantly lower than α-tocopherol (α-T). T3, especially α-T3 is known to be neuropotecti...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-5
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:Cachexia is a state of involuntary weight loss common to many chronic diseases. Experimental data, showing that cachexia is related to the enhancement of acute phase response reaction, led to the new definition of cachexia that included, aside from the principal criterion of weight loss, other "minor criteri...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-6
更新日期:2013-01-07 00:00:00
abstract:BACKGROUND:We examined the effect of seasonality on the validity (ability to estimate the mean intake of a group and ranking ability) of nutrient intakes estimated with a comprehensive self-administered diet history questionnaire (DHQ) developed for the assessment of Japanese diets during the preceding one month, using...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-51
更新日期:2014-05-31 00:00:00
abstract:BACKGROUND:Inadequate protein intake is known to be deleterious in animals. Using WHO consensus documents for human nutrient requirements, the protein:energy ratio (P:E) of an adequate diet is > 5%. Cassava has a very low protein content. This study tested the hypothesis that Nigerian and Kenyan children consuming cass...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-9-9
更新日期:2010-02-26 00:00:00
abstract:OBJECTIVE:To evaluate the association between the consumption of unhealthy foods in children under one year and the education level of the mothers, data obtained from participants of the II Survey on the prevalence of breastfeeding in the Brazilian capitals and the Federal District in 2008 was analyzed. METHODS:During...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-33
更新日期:2014-04-03 00:00:00
abstract:INTRODUCTION:Despite recent interest in the use of ketogenic diets (KDs) for cancer, evidence of beneficial effects is lacking. This study examined the impact of a randomly assigned KD on quality of life, physical activity and biomarkers in patients with breast cancer. METHOD:A total of 80 patients with locally advanc...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00596-y
更新日期:2020-08-22 00:00:00
abstract:BACKGROUND:The association between milk and dairy intake and the incidence of cardiometabolic diseases, cancer and mortality has been evaluated in many studies, but these studies have had conflicting results with no clear conclusion on causal or confounding associations. The present study aims to further address this a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0418-y
更新日期:2018-11-22 00:00:00
abstract:BACKGROUND:There are several methods of assessing nutritional status in cancer of which serum albumin is one of the most commonly used. In recent years, the role of malnutrition as a predictor of survival in cancer has received considerable attention. As a result, it is reasonable to investigate whether serum albumin h...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-9-69
更新日期:2010-12-22 00:00:00
abstract:BACKGROUND:Dietary intakes are suggested to affect age at menopause but associations between dietary factors and ovarian reserve reduction have not yet been investigated. We aimed to examine dietary intakes in relation to the rate of decline in anti-Mullerian hormone (AMH), an indicator of ovarian reserve, in a general...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0508-5
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Early enteral nutrition is recommended in cases of critical illness. It is unclear whether this recommendation is of most benefit to extremely ill patients. We aim to determine the association between illness severity and commencement of enteral feeding. METHODS:One hundred and eight critically ill patients...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-30
更新日期:2012-05-03 00:00:00
abstract:BACKGROUND:We have previously shown that a combination of glucosyl hesperidin (G-hesperidin) plus caffeine reduces accumulation of body fat, whereas G-hesperidin or caffeine alone shows little effect on high-fat diet-induced obesity in mice. The aim of this study is to evaluate the anti-obesity effect of G-hesperidin p...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-016-0123-7
更新日期:2016-01-19 00:00:00
abstract:BACKGROUND:Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri E®) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-37
更新日期:2011-04-23 00:00:00
abstract:BACKGROUND:Comprehensive assessment of dietary intakes of foods and nutrients in Filipino adults are lacking. This study evaluated energy and nutrient intakes and food sources of key nutrients consumed by Filipino adults. METHODS:The participants were from the 2013 National Nutrition Survey wherein food intake of youn...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0481-z
更新日期:2019-10-10 00:00:00
abstract:BACKGROUND:Excessive body fat is the leading cause of many metabolic disorders. Therefore, assessing levels of body fat associated with risk of disease in specific populations is crucial. The present study aimed to identify optimal cut-off values of body fat composition including total body fat, body fat percentage, vi...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00569-1
更新日期:2020-07-25 00:00:00
abstract:BACKGROUND:The cardiovascular and other health benefits and potential harms of protein and micronutrient deficiency of vegetarian diets continue to be debated. METHODS:Study participants included urban migrants, their rural siblings and urban residents (n = 6555, mean age - 40.9 yrs) of the Indian Migration Study from...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-55
更新日期:2014-06-04 00:00:00
abstract:BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hor...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-12-137
更新日期:2013-10-11 00:00:00