Abstract:
BACKGROUND:Antenatal vitamin D status may be associated with the risk of adverse pregnancy and neonatal outcomes; however, the benefits of vitamin D supplementation during pregnancy remain unknown. METHODS:We conducted a double-blind placebo-controlled randomized trial to evaluate the effect of high-dose prenatal 3rd trimester vitamin D3 supplementation on maternal and neonatal (cord blood) serum 25-hydroxyvitamin D (25(OH)D) concentration (primary biochemical efficacy outcome) and maternal serum calcium concentration (primary safety measure). Eligibility criteria were pregnant women aged 18 to <35 years, at 26 to 29 weeks gestation, and residing in Dhaka, Bangladesh. 160 women were randomized by 1:1 allocation to one of two parallel intervention groups; placebo (n = 80) or 35,000 IU/week of vitamin D3 (n = 80) until delivery. All participants, study personnel and study investigators were blind to treatment allocation. RESULTS:Mean maternal 25(OH)D concentration was similar in the vitamin D and placebo groups at baseline (45 vs. 44 nmol/L; p = 0.66), but was significantly higher in the vitamin D group vs. placebo group among mothers at delivery (134 vs. 38 nmol/L; p < 0.001) and newborns (cord blood: 103 vs. 39; p < 0.001). In the vitamin D group, 95% of neonates and 100% of mothers attained 25(OH)D >50 nmol/L, versus 21% mothers and 19% of neonates in the placebo group. No participants met criteria for hypercalcemia, there were no known supplement-related adverse events, and major pregnancy outcomes were similar between groups. CONCLUSIONS:Antenatal 3rd-trimester vitamin D3 supplementation (35,000 IU/week) significantly raised maternal and cord serum 25(OH)D concentrations above 50 nmol/L in almost all participants without inducing hypercalcemia or other observed safety concerns. Doses up to 35,000 IU/week may be cautiously used in further research aimed at establishing the clinical effects and safety of vitamin D3 supplementation in pregnancy. TRIAL REGISTRATION:This trial was registered at ClinicalTrials.gov (NCT01126528).
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Roth DE,Al Mahmud A,Raqib R,Akhtar E,Perumal N,Pezzack B,Baqui AHdoi
10.1186/1475-2891-12-47subject
Has Abstractpub_date
2013-04-12 00:00:00pages
47issn
1475-2891pii
1475-2891-12-47journal_volume
12pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Agaro-oligosaccharides derived from red seaweed polysaccharide have been reported to possess antioxidant activity. In order to assess the live protective effects of agar-oligosaccharides, we did both in vitro and in vivo studies based on own-made agaro-oligosaccharides, and the structural information of this...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-5-31
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journal_title:Nutrition journal
pub_type: 杂志文章,meta分析,评审
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abstract:BACKGROUND:To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada. METHODS:A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, ...
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pub_type: 杂志文章
doi:10.1186/1475-2891-12-70
更新日期:2013-06-02 00:00:00
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abstract:BACKGROUND:Few localized food frequency questionnaires (FFQ) have been developed and used in Chinese nutrition surveys despite China's large population and diverse dietary habits. METHOD:We analyzed data collected in two waves (six months apart) of the Shanghai Diet and Health Study in 2012-2013, from 1623 Shanghai re...
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journal_title:Nutrition journal
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-29
更新日期:2013-03-05 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-4-24
更新日期:2005-09-02 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2891-8-27
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2013-10-11 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
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更新日期:2012-11-21 00:00:00
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