Abstract:
BACKGROUND:Data on the use of lipid emulsions containing fish-oil (FO) derived n-3 polyunsaturated fatty acids (n-3 PUFAs) in addition to medium- and long-chain triglycerides (MCT/LCT) for long-term home parenteral nutrition (HPN) are limited. This study aimed to compare HPN regimens containing either MCT/LCT/FO-derived n-3 PUFAs (test group) or MCT/LCT (control group) with respect to efficacy and safety during 8 weeks of HPN using a non-inferiority trial design with change of body mass index (BMI) as primary endpoint. METHODS:This prospective, randomized, double-blind study was conducted at the Charité, Berlin, Germany, from 02/2008 until 01/2014. Adult patients (n = 42; aged 18 to 80 years) requiring HPN for at least 8 weeks were randomly assigned to the test or control group. Assessments included weight, height, physical examination (cardiovascular system, abdomen, respiratory tract, liver, spleen, kidney, urine tract, skin, mucous membrane, neurology, psyche, musculoskeletal system, lymph nodes), bio impedance analysis, calorimetry, blood samplings (haematology, biochemistry, fatty acid analysis) and quality of life questionnaire. RESULTS:BMI increased in both groups with 8 weeks of HPN (ΔBMI(test group) = 1.3 ± 1.1 kg/m2; ΔBMI(control group) = 0.6 ± 0.9 kg/m2) demonstrating non-inferiority of the test regimen regarding nutritional efficacy. Assessment of secondary efficacy endpoints revealed that after 8 weeks of HPN with the test regimen, the proportion of n-3 PUFAs in serum, platelet and red blood cell phospholipids significantly increased, while the proportion of n-6 PUFAs decreased. The fatty acid pattern in the control group remained mostly stable. No statistically significant differences were detected between groups regarding inflammatory markers or quality of life. Laboratory parameters reflecting the safety endpoints liver function, bone metabolism, renal function, metabolic activity, lipid metabolism, coagulation and haematology were stable in both groups and no group differences were detected regarding (serious) adverse events. CONCLUSIONS:The HPN regimen prepared with MCT/LCT/FO-derived n-3 PUFAs was at least as efficient in maintaining or even improving nutritional status during HPN as the control MCT/LCT regimen. Administration of FO-derived n-3 PUFAs for 8 weeks altered the fatty acid pattern of serum, platelet and red blood cell phospholipids. Both regimens were safe and well tolerated. TRIAL REGISTRATION:www.clinicaltrials.gov , registration number: NCT00530738.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Bohnert H,Maurer M,Calder PC,Pratschke J,Thul P,Müller Vdoi
10.1186/s12937-018-0419-xsubject
Has Abstractpub_date
2018-11-30 00:00:00pages
113issue
1issn
1475-2891pii
10.1186/s12937-018-0419-xjournal_volume
17pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFAs) and better cognitive outcomes in older adults. To date, only two randomised, controlled trials have assessed the effect of n-3 LC PUFA supplementation on cognitive function in older cognitively he...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-117
更新日期:2011-10-20 00:00:00
abstract:BACKGROUND:Obesity leads to an increase in inflammation and insulin resistance. This study determined antioxidant activity of flaxseed and its role in inflammation and insulin resistance in obese glucose intolerant people. METHODS:Using a randomized crossover design, nine obese glucose intolerant people consumed 40 g ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-44
更新日期:2011-05-09 00:00:00
abstract:BACKGROUND:Iodine intake is considered to be high in Japan due to regular seaweed consumption. Subgroups that do not have a traditional Japanese-style diet may consume insufficient amounts of iodine. METHOD:Three hundred and ninety apparently healthy adults (195 men and 195 women) aged 20 to 69 years from 20 areas thr...
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pub_type: 杂志文章
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更新日期:2015-12-30 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-6-26
更新日期:2007-09-21 00:00:00
abstract:BACKGROUND:Intra-articular hyaluronic acid represents a substantive addition to the therapeutic armamentarium in knee osteoarthritis. We examined the effect of dietary supplementation with a natural extract of chicken combs with a high content of hyaluronic acid (60%) (Hyal-Joint) (active test product, AP) on pain and ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-7-3
更新日期:2008-01-21 00:00:00
abstract:BACKGROUND:Many clinical studies have demonstrated that early postoperative enteral nutrition (EN) improved the postroperative course. Post-pancreaticoduodenectomy (PD), patients tend to suffer from postoperative nausea, abdominal distention, and diarrhoea, causing difficulty in the introduction of EN. In this pilot st...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-8-24
更新日期:2009-06-11 00:00:00
abstract:BACKGROUND:Insufficient iodine in children's diets is of concern because thyroid hormones are needed for normal growth and development, particularly of the brain. This study aimed to carry out a comprehensive assessment of the iodine status of New Zealand schoolchildren using a range of biochemical indices suitable for...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-31
更新日期:2012-05-08 00:00:00
abstract:BACKGROUND:There are several methods of assessing nutritional status in cancer of which serum albumin is one of the most commonly used. In recent years, the role of malnutrition as a predictor of survival in cancer has received considerable attention. As a result, it is reasonable to investigate whether serum albumin h...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
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更新日期:2010-12-22 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0030-3
更新日期:2015-05-06 00:00:00
abstract:BACKGROUND & OBJECTIVE:Nutrition assessment enables early identification of malnourished patients and those at risk of malnutrition. To determine the prevalence of malnutrition, to analyze the correlation between short-form Mini Nutritional Assessment (MNA-SF) and Nutritional Risk Screening 2002 (NRS2002) with classica...
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abstract:BACKGROUND:Cachexia is a state of involuntary weight loss common to many chronic diseases. Experimental data, showing that cachexia is related to the enhancement of acute phase response reaction, led to the new definition of cachexia that included, aside from the principal criterion of weight loss, other "minor criteri...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-6
更新日期:2013-01-07 00:00:00
abstract:BACKGROUND:Understanding associated risk for obesity is a prerequisite to develop early life interventions to arrest the increasing epidemic of metabolic syndrome and obesity among preterm born children and adolescents. FINDINGS:A retrospective review of 160 charts was conducted to determine the associated risk of bei...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-150
更新日期:2013-11-19 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0466-y
更新日期:2019-07-20 00:00:00
abstract:BACKGROUND:Because the source of protein may play a role in its satiating effect, we investigated the effect of different proteins on satiation and short-term satiety. METHODS:Two randomized single-blind cross-over studies were completed. In the first study, we investigated the effect of a preload containing 20 g of c...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-139
更新日期:2011-12-23 00:00:00
abstract:BACKGROUND:Recent studies have shown that body image perception is an important factor in weight control and may be influenced by culture and ethnicity. The aim of the present study was to assess the relationship between immigrant status of the mother and weight status and body image perception of the child. METHODS:I...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-85
更新日期:2012-10-15 00:00:00
abstract::Certain dietary patterns, in which fruits and nuts are featured prominently, reduce risk of diabetes and cardiovascular disease. However, estimated fruit consumption historically in the U.S. has been lower than recommendations. Dried fruit intake is even lower with only about 6.9 % of the adult population reporting an...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0142-4
更新日期:2016-03-05 00:00:00
abstract:BACKGROUND:Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. METHODS:We included 100 overweight and obese adults (...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-017-0229-6
更新日期:2017-02-06 00:00:00
abstract:BACKGROUND:Measuring the effects of the acute intake of natural products on human biomarker concentrations, such as those related to oxidation and inflammation, can be an advantageous strategy for early clinical research on an ingredient or product. METHODS:31 total healthy subjects were randomized in a double-blinded...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-67
更新日期:2011-06-15 00:00:00
abstract:INTRODUCTION:Despite recent interest in the use of ketogenic diets (KDs) for cancer, evidence of beneficial effects is lacking. This study examined the impact of a randomly assigned KD on quality of life, physical activity and biomarkers in patients with breast cancer. METHOD:A total of 80 patients with locally advanc...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00596-y
更新日期:2020-08-22 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,评审
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更新日期:2016-03-17 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-015-0097-x
更新日期:2015-10-16 00:00:00
abstract:BACKGROUND:The objectives of this study are to construct a cultural adopted questionnaire for evaluation of consumer's attitudes toward functional foods among Iranian's population according to Theory of Planned Behavior (TPB) and to investigate the attitudes toward vitamin enriched foods (VEF). METHODS:Participants we...
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更新日期:2020-06-16 00:00:00
abstract:BACKGROUND:The 12-month Healthy Foods North intervention program was developed to improve diet among Inuit and Inuvialuit living in Arctic Canada and assess the impact of the intervention established for the communities. METHODS:A quasi-experimental study randomly selected men and women (≥19 years of age) in six remot...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-68
更新日期:2014-07-04 00:00:00
abstract:OBJECTIVES:To determine the effects of isoflavones (soy phyto-estrogens) on serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride (TG). METHODS:We searched electronic databases and included randomized trials with isoflavones interventions i...
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pub_type: 杂志文章
doi:10.1186/1475-2891-2-15
更新日期:2003-11-19 00:00:00
abstract:BACKGROUND:Consumption of sugar-sweetened beverages, such as soda, have been shown to play an important role in weight gain. Although soda consumption has been associated with body mass index (BMI) in many studies, it has been difficult to ascertain a true causal relationship between soda consumption and BMI for two re...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-017-0269-y
更新日期:2017-08-22 00:00:00
abstract:BACKGROUND:The eating habits have changed in the last few decades, but few studies prioritize the food consumption of farmers and the rural population. Therefore, the objective of this study was explore the sociodemographic, occupational and lifestyle factors to the high adherence these dietary patterns. METHODS:This ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00542-y
更新日期:2020-03-24 00:00:00
abstract:BACKGROUND:Dietary intake of vitamin K has been reported to reduce coronary artery calcification (CAC) and cardiovascular events. However, it is unknown whether supplemental menaquinone (MK)-4 can reduce CAC or arterial stiffness. To study the effect of MK-4 supplementation on CAC and brachial ankle pulse wave velocity...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0175-8
更新日期:2016-05-12 00:00:00
abstract:BACKGROUND:In young men, unhealthy lifestyle behaviours can be detrimental to their physical and/or mental health and set them on a negative health trajectory into adulthood. Despite this, there is a lack of evidence to guide development of effective health behaviour change interventions for young men. This study asses...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-017-0227-8
更新日期:2017-01-13 00:00:00
abstract:BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hor...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-12-137
更新日期:2013-10-11 00:00:00
abstract:BACKGROUND:Micronutrient inadequate intake is responsible of pathological deficiencies and there is a need of assessing the effectiveness of metal supplementation, frequently proposed to rebalance poor diets. Manganese (Mn) is present in many enzymatic intracellular systems crucial for the regulation of cell metabolism...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-77
更新日期:2011-07-25 00:00:00