Abstract:
BACKGROUND:Parents who perceive common infant behaviors as formula intolerance-related often switch formulas without consulting a health professional. Up to one-half of formula-fed infants experience a formula change during the first six months of life. METHODS:The objective of this study was to assess discontinuance due to study physician-assessed formula intolerance in healthy, term infants. Infants (335) were randomized to receive either a standard intact cow milk protein formula (INTACT) or a partially hydrolyzed cow milk protein formula (PH) in a 60 day non-inferiority trial. Discontinuance due to study physician-assessed formula intolerance was the primary outcome. Secondary outcomes included number of infants who discontinued for any reason, including parent-assessed. RESULTS:Formula intolerance between groups (INTACT, 12.3% vs. PH, 13.7%) was similar for infants who completed the study or discontinued due to study physician-assessed formula intolerance. Overall study discontinuance based on parent- vs. study physician-assessed intolerance for all infants (14.4 vs.11.1%) was significantly different (P = 0.001). CONCLUSION:This study demonstrated no difference in infant tolerance of intact vs. partially hydrolyzed cow milk protein formulas for healthy, term infants over a 60-day feeding trial, suggesting nonstandard partially hydrolyzed formulas are not necessary as a first-choice for healthy infants. Parents frequently perceived infant behavior as formula intolerance, paralleling previous reports of unnecessary formula changes. TRIAL REGISTRATION:clinicaltrials.gov: NCT00666120.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Berseth CL,Mitmesser SH,Ziegler EE,Marunycz JD,Vanderhoof Jdoi
10.1186/1475-2891-8-27subject
Has Abstractpub_date
2009-06-19 00:00:00pages
27issn
1475-2891pii
1475-2891-8-27journal_volume
8pub_type
杂志文章,多中心研究,随机对照试验abstract:BACKGROUND:Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and early mortality. Excessive shortening of telomere is a marker of accelerated aging and can be influenced by oxidative stress and nutritional deficiency. Plasma n6:n3 polyunsaturated fatty acid...
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journal_title:Nutrition journal
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Nutrition journal
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-11-20 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2011-05-28 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-02-06 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
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更新日期:2011-12-23 00:00:00
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pub_type: 杂志文章
doi:10.1186/1475-2891-8-19
更新日期:2009-05-04 00:00:00