Abstract:
BACKGROUND:Intra-articular hyaluronic acid represents a substantive addition to the therapeutic armamentarium in knee osteoarthritis. We examined the effect of dietary supplementation with a natural extract of chicken combs with a high content of hyaluronic acid (60%) (Hyal-Joint) (active test product, AP) on pain and quality of life in subjects with osteoarthritis of the knee. METHODS:Twenty subjects aged > or =40 years with knee osteoarthritis (pain for at least 15 days in the previous month, symptoms present for > or =6 months, Kellgren/Lawrence score > or =2) participated in a randomized double-blind controlled trial. Ten subjects received AP (80 mg/day) and 10 placebo for 8 weeks. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and quality of life by the Short Form-36 (SF-36v2) were administered at baseline and after 4 and 8 weeks of treatment. RESULTS:WOMAC pain (primary efficacy variable) was similar in both study groups (mean [SD]) with 6.6 (4.0) points in the AP group and 6.4 (2.7) in the placebo group (P = 0.943). As compared with baseline, subjects in both groups showed statistically significant improvements in WOMAC pain, stiffness, physical function subscales, and in the aggregate score, but the magnitude of changes was higher in the AP group for WOMAC physical function (-13.1 [12.0] vs. -10.1 [8.6], P = 0.575) and total symptoms (-18.6 [16.8] vs. -15.8 [11.4], P = 0.694). At 4 weeks, statistically significant mean changes compared with baseline were observed in the SF-36v2 scales of role-physical, bodily pain, social functioning and role-emotional among subjects in the AP group, and in physical functioning, bodily pain, and social functioning in the placebo group. At 8 weeks, changes were significant for role-physical, bodily pain, and physical component summary in the AP group, and for physical functioning and role-emotional in the placebo arm. Changes in bodily pain and social functioning were of greater magnitude in subjects given AP. CONCLUSION:This pilot clinical trial showed that daily supplementation with oral hyaluronic acid from a natural extract of chicken combs (Hyal-Joint) was useful to enhance several markers of quality of life in adults with osteoarthritis of the knee. The results warrant further study in larger sample sizes.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Kalman DS,Heimer M,Valdeon A,Schwartz H,Sheldon Edoi
10.1186/1475-2891-7-3subject
Has Abstractpub_date
2008-01-21 00:00:00pages
3issn
1475-2891pii
1475-2891-7-3journal_volume
7pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Because the source of protein may play a role in its satiating effect, we investigated the effect of different proteins on satiation and short-term satiety. METHODS:Two randomized single-blind cross-over studies were completed. In the first study, we investigated the effect of a preload containing 20 g of c...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-139
更新日期:2011-12-23 00:00:00
abstract:BACKGROUND:Children in food-insecure families face increased barriers to meeting recommendations for fruit and vegetable consumption. Hospitals and pediatric healthcare institutions have attempted to alleviate food-insecurity through various internal programs like food prescriptions, yet little evidence for these progr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00616-x
更新日期:2020-09-09 00:00:00
abstract:BACKGROUND:Dietary assessment methods that can provide high quality data while limiting participant burden and resource requirements in epidemiological research are highly sought after and continue to evolve. The use of mobile phone technology in research has increased rapidly over the last decade and offers multiple a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0315-4
更新日期:2018-01-09 00:00:00
abstract:BACKGROUND:The plant stanol ester margarine Benecol is a functional food that has been shown to lower effectively serum total and LDL-cholesterol. The purpose of this post-marketing study is to characterize users of plant stanol ester margarine with and without cardiovascular disease. METHODS:A cohort of plant stanol ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-4-20
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Dietary intake of vitamin K has been reported to reduce coronary artery calcification (CAC) and cardiovascular events. However, it is unknown whether supplemental menaquinone (MK)-4 can reduce CAC or arterial stiffness. To study the effect of MK-4 supplementation on CAC and brachial ankle pulse wave velocity...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0175-8
更新日期:2016-05-12 00:00:00
abstract:BACKGROUND:The 12-month Healthy Foods North intervention program was developed to improve diet among Inuit and Inuvialuit living in Arctic Canada and assess the impact of the intervention established for the communities. METHODS:A quasi-experimental study randomly selected men and women (≥19 years of age) in six remot...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-68
更新日期:2014-07-04 00:00:00
abstract:BACKGROUND:Dietary assessment methods that are user-friendly, simple, yet valid are of interest to both researchers and participants, particularly for use in disadvantaged settings, where language barriers and low levels of education are often present. We tested if parents taking photos of what children ate, using mobi...
journal_title:Nutrition journal
pub_type: 杂志文章
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更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Low diet quality and depression symptoms are independently associated with poor glycemic control in subjects with type 2 diabetes (T2D); however, the relationship between them is unclear. The aim of this study was to determine the association between diet quality and symptoms of depression among Cuban-Americ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-135
更新日期:2011-12-09 00:00:00
abstract:BACKGROUND:Our previous studies demonstrated that dietary supplementation with milk fat globule membrane (MFGM) combined with habitual exercise improved muscle strength by stimulating neuromuscular development in mice. This study aimed to demonstrate the beneficial effects of dietary MFGM supplementation plus regular e...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0073-5
更新日期:2015-08-25 00:00:00
abstract:BACKGROUND:Dietary fibre food intake is related to a reduced risk of developing diabetes mellitus. However, the mechanism of this effect is still not clear. The aim of this study was to evaluate the effect of commercial fibre cereals on the rate of gastric emptying, postprandial glucose response and satiety in healthy ...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2007-09-17 00:00:00
abstract:BACKGROUND:Comprehensive assessment of dietary intakes of foods and nutrients in Filipino adults are lacking. This study evaluated energy and nutrient intakes and food sources of key nutrients consumed by Filipino adults. METHODS:The participants were from the 2013 National Nutrition Survey wherein food intake of youn...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0481-z
更新日期:2019-10-10 00:00:00
abstract:BACKGROUND:High level of serum cholesterol is considered to be a major risk factor for cardiovascular disease (CVD). A double-blinded, randomized, placebo-controlled trial was performed to test the hypothesis that a daily intake of Chlorella may improve serum lipid profile through enhancement of serum carotenoid concen...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-57
更新日期:2014-06-11 00:00:00
abstract:BACKGROUND:Understanding associated risk for obesity is a prerequisite to develop early life interventions to arrest the increasing epidemic of metabolic syndrome and obesity among preterm born children and adolescents. FINDINGS:A retrospective review of 160 charts was conducted to determine the associated risk of bei...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-150
更新日期:2013-11-19 00:00:00
abstract:BACKGROUND:Due to the absence of a current and validated food frequency questionnaire (FFQ) for use in New Zealand adolescents, there is a need to develop one as a cost-effective way to assess adolescents' food patterns. This study aims to examine the test-retest reliability and relative validity of the New Zealand Ado...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-65
更新日期:2012-09-05 00:00:00
abstract:BACKGROUND:Based on data obtained from pregnant women who participated in the Mothers and Children's Environmental Health (MOCEH) study in South Korea, we aimed to determine whether maternal intake of fruits and vegetables or vitamin C is associated with fetal and infant growth. METHODS:A total of 1138 Korean pregnant...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究
doi:10.1186/s12937-018-0410-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:The aim of this study was to describe the clinical features, haematological findings and CD4+ and CD8+ cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection. METHODS:The study was conducted in the paediatric wards of Mulago hospital, which is Uganda's nati...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-5-27
更新日期:2006-10-16 00:00:00
abstract:BACKGROUND:This study examined the association of breakfast consumption, and the type of breakfast consumed, with body mass index (BMI; kg/m(2)) and prevalence rates and odds ratios (OR) of overweight/obesity among Canadian adults. These associations were examined by age group and sex. METHODS:We used data from non-pr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0151-3
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:A number of studies have reported the association between dietary patterns and the risk of chronic kidney disease (CKD), however a consistent perspective hasn't been established to date. Herein, we conducted this systematic review and meta-analysis of observational studies to assess the association between d...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
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更新日期:2021-01-08 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-77
更新日期:2011-07-25 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-93
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abstract:BACKGROUND:Obesity develops when energy intake continuously exceeds energy expenditure, causing a fundamental chronic energy imbalance. Societal and behavioural changes over the last decades are held responsible for the considerable increase in sedentary lifestyles and inappropriate dietary patterns. The role of dietar...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-6-26
更新日期:2007-09-21 00:00:00
abstract:BACKGROUND:Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China. The aim of this study was to assess the iodine status in vulnerable groups from different geogr...
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pub_type: 杂志文章
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更新日期:2020-01-21 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
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更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:Nocturnal eating have recently increased. Serum phosphorus levels and regulators of phosphorus have circadian variations, so it is suggested that the timing of eating may be important in controlling serum phosphorus levels. However, there have been no reports on the effects of nocturnal eating on phosphorus ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0096-y
更新日期:2015-10-08 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-3-13
更新日期:2004-09-13 00:00:00
abstract:BACKGROUND:Insufficient iodine in children's diets is of concern because thyroid hormones are needed for normal growth and development, particularly of the brain. This study aimed to carry out a comprehensive assessment of the iodine status of New Zealand schoolchildren using a range of biochemical indices suitable for...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-31
更新日期:2012-05-08 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-4-24
更新日期:2005-09-02 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-8-24
更新日期:2009-06-11 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-9
更新日期:2014-01-22 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-14-3
更新日期:2015-01-05 00:00:00