Impact of menaquinone-4 supplementation on coronary artery calcification and arterial stiffness: an open label single arm study.

Abstract:

BACKGROUND:Dietary intake of vitamin K has been reported to reduce coronary artery calcification (CAC) and cardiovascular events. However, it is unknown whether supplemental menaquinone (MK)-4 can reduce CAC or arterial stiffness. To study the effect of MK-4 supplementation on CAC and brachial ankle pulse wave velocity (baPWV). METHODS:This study is a single arm design to take 45 mg/day MK-4 daily as a therapeutic drug for 1 year. Primary endpoint was CAC score determined using 64-slice multislice CT (Siemens), and the secondary endpoint was baPWV measured before and 1 year after MK-4 therapy. RESULTS:A total of 26 patients were enrolled. The average age was 69 ± 8 years and 65 % were female. Plasma levels of phylloquinone (PK), MK-7, and MK4 were 1.94 ± 1.38 ng/ml, 14.2 ± 11.9 ng/ml and 0.4 ± 2.0 ng/ml, respectively, suggesting that MK-7 was the dominant vitamin K in the studied population. Baseline CAC and baPWV were 513 ± 773 and 1834 ± 289 cm/s, respectively. At 1 year following MK-4 supplementation, the values were 588 ± 872 (+14 %) and 1821 ± 378 cm/s (-0.7 %), respectively. In patients with high PIVKA-2, -18 % annual reduction of baPWV was observed. CONCLUSION:Despite high dose MK-4 supplementation, CAC increased +14 % annually, but baPWV did not change (-0.7 %). The benefits of MK-4 supplementation were only observed in patients with vitamin K insufficiencies correlated with high PIVKA-2 baseline levels, reducing baPWV but not CAC. TRIAL REGISTRATION:This study was registered as UMIN 000002760.

journal_name

Nutr J

journal_title

Nutrition journal

authors

Ikari Y,Torii S,Shioi A,Okano T

doi

10.1186/s12937-016-0175-8

subject

Has Abstract

pub_date

2016-05-12 00:00:00

pages

53

issue

1

issn

1475-2891

pii

10.1186/s12937-016-0175-8

journal_volume

15

pub_type

杂志文章
  • Inadequate physician knowledge of the effects of diet on blood lipids and lipoproteins.

    abstract:BACKGROUND:To assess the nutrition knowledge of physicians on the basic effects of diet on blood lipids and lipoproteins. METHODS:Anonymous mailed dietary knowledge surveys to 6000 randomly selected physicians in the United States licensed in either Internal Medicine or Cardiology. RESULTS:Response rate: 16% (n = 639...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-2-19

    authors: Flynn M,Sciamanna C,Vigilante K

    更新日期:2003-12-01 00:00:00

  • Measurement and definitions of obesity in childhood and adolescence: a field guide for the uninitiated.

    abstract::This paper aims to guide readers embarking on the complex literature in respect of childhood and adolescent obesity. It opens with a discussion of definitions of 'obesity' based on overall fat levels and the significance of fat distribution. This is followed by simple descriptions of the various techniques used to mea...

    journal_title:Nutrition journal

    pub_type: 杂志文章,评审

    doi:10.1186/1475-2891-6-32

    authors: Sweeting HN

    更新日期:2007-10-26 00:00:00

  • The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial.

    abstract:BACKGROUND:Recommendations for daily dietary vegetable intake were increased in the 2005 USDA Dietary Guidelines as consumption of a diet rich in vegetables has been associated with lower risk of certain chronic health disorders including cardiovascular disease. However, vegetable consumption in the United States has d...

    journal_title:Nutrition journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1475-2891-9-38

    authors: Shenoy SF,Kazaks AG,Holt RR,Chen HJ,Winters BL,Khoo CS,Poston WS,Haddock CK,Reeves RS,Foreyt JP,Gershwin ME,Keen CL

    更新日期:2010-09-17 00:00:00

  • Protocol for a randomized controlled trial to test the acceptability and adherence to 6-months of walnut supplementation in Chinese adults at high risk of cardiovascular disease.

    abstract:BACKGROUND:Consumption of nuts improves cardio-metabolic risk factors in clinical trials and relates to lower risk of cardiovascular disease (CVD) in prospective observational studies. However, there has not been an adequately powered randomized controlled trial to test if nuts supplementation actually reduces incident...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-00660-7

    authors: Liu Y,Li N,Yan N,Pan XF,Li Q,Micha R,Mozaffarian D,Huffman MD,Wang Y,Neal B,Tian M,Zhao Y,Wu JHY

    更新日期:2021-01-06 00:00:00

  • Socioeconomic and ethnic differences in the relation between dietary costs and dietary quality: the HELIUS study.

    abstract:BACKGROUND:Healthier dietary patterns are generally more costly than less healthy patterns, but dietary costs may be more important for dietary quality in lower educated and ethnic minority groups. The aim of this study was to investigate the association between dietary costs and dietary quality and interactions with e...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-019-0445-3

    authors: Mackenbach JD,Dijkstra SC,Beulens JWJ,Seidell JC,Snijder MB,Stronks K,Monsivais P,Nicolaou M

    更新日期:2019-03-28 00:00:00

  • Efficacy and safety of oral branched-chain amino acid supplementation in patients undergoing interventions for hepatocellular carcinoma: a meta-analysis.

    abstract::Most hepatocellular carcinoma (HCC) patients have complications, including cirrhosis and malnutrition. The efficacy of dietary supplementation with oral branched-chain amino acids (BCAAs) in HCC patients undergoing interventions has not been confirmed. Relevant publications on the efficacy and safety of oral BCAA supp...

    journal_title:Nutrition journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12937-015-0056-6

    authors: Chen L,Chen Y,Wang X,Li H,Zhang H,Gong J,Shen S,Yin W,Hu H

    更新日期:2015-07-09 00:00:00

  • Lutein-fortified infant formula fed to healthy term infants: evaluation of growth effects and safety.

    abstract:BACKGROUND/OBJECTIVES:Breast milk contains lutein derived from the mother's diet. This carotenoid is currently not added to infant formula, which has a small and variable lutein content from innate ingredients. This study was conducted to compare the growth of infants fed lutein-fortified infant formula with that of in...

    journal_title:Nutrition journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1475-2891-9-22

    authors: Capeding R,Gepanayao CP,Calimon N,Lebumfacil J,Davis AM,Stouffer N,Harris BJ

    更新日期:2010-05-21 00:00:00

  • An empirical investigation of the impact of smoking on body weight using an endogenous treatment effects model approach: the role of food consumption patterns.

    abstract:BACKGROUND:This study explored the influence of cigarette smoking and food consumption patterns on BMI after adjusting for various socio-demographic characteristics. Since weight-based stereotypes may have an impact on smoking behaviour and both obesity and smoking have been associated with detrimental health effects, ...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-018-0408-0

    authors: Raptou E,Papastefanou G

    更新日期:2018-11-05 00:00:00

  • Geographical influences on the iodine status in pregnant women, neonates, and school-age children in China.

    abstract:BACKGROUND:Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China. The aim of this study was to assess the iodine status in vulnerable groups from different geogr...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-0525-4

    authors: Lou X,Wang X,Mao G,Zhu W,Mo Z,Wang Y,Wang Z

    更新日期:2020-01-21 00:00:00

  • Assessment of attitudes toward functional foods based on theory of planned behavior: validation of a questionnaire.

    abstract:BACKGROUND:The objectives of this study are to construct a cultural adopted questionnaire for evaluation of consumer's attitudes toward functional foods among Iranian's population according to Theory of Planned Behavior (TPB) and to investigate the attitudes toward vitamin enriched foods (VEF). METHODS:Participants we...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-00574-4

    authors: Salmani F,Norozi E,Moodi M,Zeinali T

    更新日期:2020-06-16 00:00:00

  • Diet and lifestyle factors associated with fish consumption in men and women: a study of whether gender differences can result in gender-specific confounding.

    abstract:BACKGROUND:Fish consumption and intake of omega-3 fatty acids from fish are associated with a lower risk of cardiovascular disease. However, a prospective study from northern Sweden showed that high consumption of fish is associated with an increased risk of stroke in men, but not in women. The current study aimed to d...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-11-101

    authors: Wennberg M,Tornevi A,Johansson I,Hörnell A,Norberg M,Bergdahl IA

    更新日期:2012-12-04 00:00:00

  • Validity and reliability of a food frequency questionnaire for assessing dietary intake among Shanghai residents.

    abstract:BACKGROUND:Few localized food frequency questionnaires (FFQ) have been developed and used in Chinese nutrition surveys despite China's large population and diverse dietary habits. METHOD:We analyzed data collected in two waves (six months apart) of the Shanghai Diet and Health Study in 2012-2013, from 1623 Shanghai re...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-019-0454-2

    authors: Zang J,Luo B,Chang S,Jin S,Shan C,Ma L,Zhu Z,Guo C,Zou S,Jia X,Wu F

    更新日期:2019-05-23 00:00:00

  • Association of plasma chromium with metabolic syndrome among Chinese adults: a case-control study.

    abstract:BACKGROUD:Chromium has been suggested playing a role in alleviating diabetes, insulin resistance and lipid anomalies, but the effect on metabolic syndrome (MetS) in humans remains controversial. METHODS:We conducted a matched case-control study in a Chinese population, involving 2141 MetS cases and 2141 healthy contro...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-00625-w

    authors: Chen S,Zhou L,Guo Q,Fang C,Wang M,Peng X,Yin J,Li S,Zhu Y,Yang W,Zhang Y,Shan Z,Chen X,Liu L

    更新日期:2020-09-23 00:00:00

  • Association between metabolic abnormalities and HBV related hepatocelluar carcinoma in Chinese: a cross-sectional study.

    abstract:BACKGROUND:Previous studies suggested that the abnormality of metabolism is a newly identified risk factor in HBV-related hepatocellular carcinoma (HCC). The association between metabolic factors and hepatocellular carcinoma (HCC) has not been clarified up to now. This study was conducted to investigate the prevalence ...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-10-49

    authors: Zhao J,Zhao Y,Wang H,Gu X,Ji J,Gao C

    更新日期:2011-05-15 00:00:00

  • Determinants for early introduction of complementary foods in Australian infants: findings from the HSHK birth cohort study.

    abstract:OBJECTIVE:The purpose of this study was to examine the timing of introduction of complementary (solid) foods among infants in South Western Sydney, Australia, and describe the maternal and infant characteristics associated with very early introduction of solids. METHODS:Mother-infant dyads (n = 1035) were recruited in...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-0528-1

    authors: Arora A,Manohar N,Hector D,Bhole S,Hayen A,Eastwood J,Scott JA

    更新日期:2020-02-18 00:00:00

  • Eating habits of a population undergoing a rapid dietary transition: portion sizes of traditional and non-traditional foods and beverages consumed by Inuit adults in Nunavut, Canada.

    abstract:BACKGROUND:To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada. METHODS:A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, ...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-12-70

    authors: Sheehy T,Roache C,Sharma S

    更新日期:2013-06-02 00:00:00

  • Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled clinical trial.

    abstract:INTRODUCTION:Despite recent interest in the use of ketogenic diets (KDs) for cancer, evidence of beneficial effects is lacking. This study examined the impact of a randomly assigned KD on quality of life, physical activity and biomarkers in patients with breast cancer. METHOD:A total of 80 patients with locally advanc...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-020-00596-y

    authors: Khodabakhshi A,Seyfried TN,Kalamian M,Beheshti M,Davoodi SH

    更新日期:2020-08-22 00:00:00

  • Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight.

    abstract:BACKGROUND:Studies have suggested a link between alcohol intake and adiposity. However, results from longitudinal studies have been inconsistent, and a possible interaction with genetic predisposition to adiposity measures has often not been taken into account. OBJECTIVE:To examine the association between alcohol inta...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-017-0274-1

    authors: Rohde JF,Ängquist L,Larsen SC,Tolstrup JS,Husemoen LLN,Linneberg A,Toft U,Overvad K,Halkjær J,Tjønneland A,Hansen T,Pedersen O,Sørensen TIA,Heitmann BL

    更新日期:2017-08-25 00:00:00

  • Impact of dairy consumption on essential hypertension: a clinical study.

    abstract:BACKGROUND:Several studies have presented evidence suggesting that dairy consumption has beneficial effects on blood pressure (BP) in healthy subjects; however, only a few studies have examined this possibility in patients with established essential hypertension using ambulatory blood pressure monitoring. The objective...

    journal_title:Nutrition journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1475-2891-13-83

    authors: Drouin-Chartier JP,Gigleux I,Tremblay AJ,Poirier L,Lamarche B,Couture P

    更新日期:2014-08-14 00:00:00

  • Food sources, energy and nutrient intakes of adults: 2013 Philippines National Nutrition Survey.

    abstract:BACKGROUND:Comprehensive assessment of dietary intakes of foods and nutrients in Filipino adults are lacking. This study evaluated energy and nutrient intakes and food sources of key nutrients consumed by Filipino adults. METHODS:The participants were from the 2013 National Nutrition Survey wherein food intake of youn...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-019-0481-z

    authors: Angeles-Agdeppa I,Sun Y,Denney L,Tanda KV,Octavio RAD,Carriquiry A,Capanzana MV

    更新日期:2019-10-10 00:00:00

  • Dietary patterns and chronic kidney disease risk: a systematic review and updated meta-analysis of observational studies.

    abstract:BACKGROUND:A number of studies have reported the association between dietary patterns and the risk of chronic kidney disease (CKD), however a consistent perspective hasn't been established to date. Herein, we conducted this systematic review and meta-analysis of observational studies to assess the association between d...

    journal_title:Nutrition journal

    pub_type: 杂志文章,评审

    doi:10.1186/s12937-020-00661-6

    authors: He LQ,Wu XH,Huang YQ,Zhang XY,Shu L

    更新日期:2021-01-08 00:00:00

  • Physical activity, energy requirements, and adequacy of dietary intakes of older persons in a rural Filipino community.

    abstract:BACKGROUND:Aging is a process associated with physiological changes such as in body composition, energy expenditure and physical activity. Data on energy and nutrient intake adequacy among elderly is important for disease prevention, health maintenance and program development. METHODS:This descriptive cross-sectional ...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-8-19

    authors: Risonar MG,Rayco-Solon P,Ribaya-Mercado JD,Solon JA,Cabalda AB,Tengco LW,Solon FS

    更新日期:2009-05-04 00:00:00

  • Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials.

    abstract:BACKGROUND AND AIM:Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect of fenugreek intake o...

    journal_title:Nutrition journal

    pub_type: 杂志文章,meta分析

    doi:10.1186/1475-2891-13-7

    authors: Neelakantan N,Narayanan M,de Souza RJ,van Dam RM

    更新日期:2014-01-18 00:00:00

  • Effect of vitamin E (Tri E®) on antioxidant enzymes and DNA damage in rats following eight weeks exercise.

    abstract:BACKGROUND:Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri E®) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) a...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-10-37

    authors: Abd Hamid NA,Hasrul MA,Ruzanna RJ,Ibrahim IA,Baruah PS,Mazlan M,Yusof YA,Ngah WZ

    更新日期:2011-04-23 00:00:00

  • Feasibility of a commercial smartphone application for dietary assessment in epidemiological research and comparison with 24-h dietary recalls.

    abstract:BACKGROUND:Dietary assessment methods that can provide high quality data while limiting participant burden and resource requirements in epidemiological research are highly sought after and continue to evolve. The use of mobile phone technology in research has increased rapidly over the last decade and offers multiple a...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-018-0315-4

    authors: Ambrosini GL,Hurworth M,Giglia R,Trapp G,Strauss P

    更新日期:2018-01-09 00:00:00

  • Evaluation of antiaggregatory activity of flavonoid aglycone series.

    abstract:BACKGROUND:Among natural compounds, present in every day diet, flavonoids have shown beneficial effect in prevention of cardiovascular diseases that can be attributed, at least partially to the described antiaggregatory activity i.e. antiplatelet effects of flavonoids. Due to the ever increasing pharmacological interes...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-10-73

    authors: Bojić M,Debeljak Z,Tomičić M,Medić-Šarić M,Tomić S

    更新日期:2011-07-11 00:00:00

  • Effect of different protein sources on satiation and short-term satiety when consumed as a starter.

    abstract:BACKGROUND:Because the source of protein may play a role in its satiating effect, we investigated the effect of different proteins on satiation and short-term satiety. METHODS:Two randomized single-blind cross-over studies were completed. In the first study, we investigated the effect of a preload containing 20 g of c...

    journal_title:Nutrition journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1475-2891-10-139

    authors: Abou-Samra R,Keersmaekers L,Brienza D,Mukherjee R,Macé K

    更新日期:2011-12-23 00:00:00

  • Dietary pattern is associated with obesity in Chinese children and adolescents: data from China Health and Nutrition Survey (CHNS).

    abstract:BACKGROUND:Associations of dietary patterns in Chinese adolescents and children with later obesity have not previously been investigated. The purpose of the present study was to evaluate the associations between dietary patterns and the risk of obesity in Chinese adolescents and children by using a longitudinal design....

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/s12937-018-0372-8

    authors: Zhen S,Ma Y,Zhao Z,Yang X,Wen D

    更新日期:2018-07-11 00:00:00

  • The consumption of unhealthy foods by Brazilian children is influenced by their mother's educational level.

    abstract:OBJECTIVE:To evaluate the association between the consumption of unhealthy foods in children under one year and the education level of the mothers, data obtained from participants of the II Survey on the prevalence of breastfeeding in the Brazilian capitals and the Federal District in 2008 was analyzed. METHODS:During...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-13-33

    authors: Saldiva SR,Venancio SI,de Santana AC,da Silva Castro AL,Escuder MM,Giugliani ER

    更新日期:2014-04-03 00:00:00

  • Effect of seasonality on the estimated mean value of nutrients and ranking ability of a self-administered diet history questionnaire.

    abstract:BACKGROUND:We examined the effect of seasonality on the validity (ability to estimate the mean intake of a group and ranking ability) of nutrient intakes estimated with a comprehensive self-administered diet history questionnaire (DHQ) developed for the assessment of Japanese diets during the preceding one month, using...

    journal_title:Nutrition journal

    pub_type: 杂志文章

    doi:10.1186/1475-2891-13-51

    authors: Suga H,Asakura K,Sasaki S,Nojima M,Okubo H,Hirota N,Notsu A,Fukui M,Date C

    更新日期:2014-05-31 00:00:00