Abstract:
INTRODUCTION:Despite recent interest in the use of ketogenic diets (KDs) for cancer, evidence of beneficial effects is lacking. This study examined the impact of a randomly assigned KD on quality of life, physical activity and biomarkers in patients with breast cancer. METHOD:A total of 80 patients with locally advanced or metastatic breast cancer and without a history of renal disease or diabetes were randomly assigned to either a KD or a control group for this 12-week trial. Concurrent with the first, third, and fifth chemotherapy sessions, quality of life, physical activity, and biomarkers (thyroid function tests, electrolytes, albumin, ammonia, ALP, lactate and serum ketones) were assessed. Dietary intake was also recorded on admission and the end of the treatment. RESULTS:No significant differences were seen in quality of life or physical activity scores between the two groups after 12 weeks; however, the KD group showed higher global quality of life and physical activity scores compared to the control group at 6 weeks (P = 0.02 P = 0.01). Also, serum lactate and ALP levels decreased significantly in the KD group compared to the control group at the end of the intervention (10.7 ± 3 vs 13.3 ± 4, 149 ± 71 vs 240 ± 164, P = 0.02 and P = 0.007, respectively). A significant inverse association was observed between total carbohydrate intake and serum beta-hydroxybutyrate at 12 weeks (r = - 0.77 P < 0.001). No significant differences between groups were observed in thyroid hormones, electrolytes, albumin, LDH or ammonia. Compliance among KD subjects ranged from 66.7 to 79.2% as assessed by dietary intake and serum ketones levels of > 0.5. CONCLUSION:According to our results, besides a higher global quality of life and physical activity scores compared to the control group at 6 weeks, KD diet combined to chemotherapy in patients with breast cancer does not bring additional benefit about quality of life and physical activity at 12 weeks. However, decreases seen in levels of lactate and ALP in the KD group suggest that a KD may benefit patients with breast cancer. TRIAL REGISTRATION:This trial has been registered on Iranian Registry of Clinical Trials (IRCT) under the identification code: IRCT20171105037259N2 https://www.irct.ir/trial/30755.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Khodabakhshi A,Seyfried TN,Kalamian M,Beheshti M,Davoodi SHdoi
10.1186/s12937-020-00596-ysubject
Has Abstractpub_date
2020-08-22 00:00:00pages
87issue
1issn
1475-2891pii
10.1186/s12937-020-00596-yjournal_volume
19pub_type
杂志文章abstract:BACKGROUND:The consumption of fruit is generally associated with better health, but also higher socioeconomic status (SES). Most previous studies evaluating consumption of fruits have not separated 100% fruit juice and whole fruit, which may conceal interesting patterns in consumption. OBJECTIVE:To estimate demographi...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-14-3
更新日期:2015-01-05 00:00:00
abstract:BACKGROUND:Inadequate protein intake is known to be deleterious in animals. Using WHO consensus documents for human nutrient requirements, the protein:energy ratio (P:E) of an adequate diet is > 5%. Cassava has a very low protein content. This study tested the hypothesis that Nigerian and Kenyan children consuming cass...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-9-9
更新日期:2010-02-26 00:00:00
abstract:BACKGROUND:Dietary assessment methods that can provide high quality data while limiting participant burden and resource requirements in epidemiological research are highly sought after and continue to evolve. The use of mobile phone technology in research has increased rapidly over the last decade and offers multiple a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0315-4
更新日期:2018-01-09 00:00:00
abstract:OBJECTIVES:To determine the effects of isoflavones (soy phyto-estrogens) on serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) and triglyceride (TG). METHODS:We searched electronic databases and included randomized trials with isoflavones interventions i...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-2-15
更新日期:2003-11-19 00:00:00
abstract:BACKGROUND:Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown. OBJECTIVE:This study examined the effec...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-11-98
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Poor diet is thought to be a risk factor for many diseases, including age-related macular disease (ARMD), which is the leading cause of blind registration in those aged over 60 years in the developed world. The aims of this study were 1) to evaluate the dietary food intake of three subject groups: participan...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-3-16
更新日期:2004-09-28 00:00:00
abstract:BACKGROUND:Arterial stiffness is a component of vascular function and an established risk factor for cardiovascular disease. There is a lack of conclusive evidence on the effect of a meal rich in monounsaturated fat (MUFA) compared with an isoenergetic meal rich in saturated fat (SFA) on postprandial vascular function ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-12-93
更新日期:2013-07-10 00:00:00
abstract:BACKGROUND:This study explored the influence of cigarette smoking and food consumption patterns on BMI after adjusting for various socio-demographic characteristics. Since weight-based stereotypes may have an impact on smoking behaviour and both obesity and smoking have been associated with detrimental health effects, ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0408-0
更新日期:2018-11-05 00:00:00
abstract:BACKGROUND:Dietary assessment methods that are user-friendly, simple, yet valid are of interest to both researchers and participants, particularly for use in disadvantaged settings, where language barriers and low levels of education are often present. We tested if parents taking photos of what children ate, using mobi...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00558-4
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Measuring the effects of the acute intake of natural products on human biomarker concentrations, such as those related to oxidation and inflammation, can be an advantageous strategy for early clinical research on an ingredient or product. METHODS:31 total healthy subjects were randomized in a double-blinded...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-67
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:Obesity is the most relevant overnutrition disease worldwide and is associated to different metabolic disorders such as insulin resistance and type-2 diabetes. Low glycemic load foods and diets and moderately high protein intake have been shown to reduce body weight and fat mass, exerting also beneficial eff...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-10-74
更新日期:2011-07-14 00:00:00
abstract:BACKGROUND:Constipation is a common occurrence in formula-fed infants. The aim of this preliminary study was to evaluate the impact of a formula with high levels of lactose and magnesium, in compliance with the official regulations, on stool water content, as well as a parental assessment of constipation. MATERIALS AN...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-55
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFAs) and better cognitive outcomes in older adults. To date, only two randomised, controlled trials have assessed the effect of n-3 LC PUFA supplementation on cognitive function in older cognitively he...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-117
更新日期:2011-10-20 00:00:00
abstract:BACKGROUND:Associations of dietary patterns in Chinese adolescents and children with later obesity have not previously been investigated. The purpose of the present study was to evaluate the associations between dietary patterns and the risk of obesity in Chinese adolescents and children by using a longitudinal design....
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0372-8
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:Due to the absence of a current and validated food frequency questionnaire (FFQ) for use in New Zealand adolescents, there is a need to develop one as a cost-effective way to assess adolescents' food patterns. This study aims to examine the test-retest reliability and relative validity of the New Zealand Ado...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-65
更新日期:2012-09-05 00:00:00
abstract:BACKGROUND:Decreased ability of muscles to respond to anabolic stimuli is part of the underlying mechanism for muscle loss with aging. Previous studies suggest that substantial amounts of essential amino acids (EAA), whey protein and leucine are beneficial for stimulation of acute muscle protein synthesis in older adul...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-9
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:The extent to which psychosocial and diet behavior factors affect dietary self-report remains unclear. We examine the contribution of these factors to measurement error of self-report. METHODS:In 450 postmenopausal women in the Women's Health Initiative Observational Study doubly labeled water and urinary n...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-63
更新日期:2013-05-16 00:00:00
abstract:BACKGROUND:There are several methods of assessing nutritional status in cancer of which serum albumin is one of the most commonly used. In recent years, the role of malnutrition as a predictor of survival in cancer has received considerable attention. As a result, it is reasonable to investigate whether serum albumin h...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-9-69
更新日期:2010-12-22 00:00:00
abstract:BACKGROUND:There is a promising outlook regarding the potential effect of spinach-derived thylakoids in the management of obesity and its associated metabolic disturbances. This research aimed to evaluate the effects of spinach-derived thylakoids supplementation combined with a calorie-restricted diet on anthropometric...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00601-4
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Several studies have shown that cocoa and cocoa-containing foods have the potential to lower blood pressure and improve endothelial function. Most of the studies reporting the beneficial effects of dark chocolate on blood pressure have been short (≤ 4 weeks). The aim of the present 8-wks (weeks) study was to...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0075-3
更新日期:2015-08-22 00:00:00
abstract::Nutrition support programs that only focus upon better complementary feeding remain an insufficient means of limiting growth faltering in vulnerable populations of children. To determine if symptoms of acute infections correlate with the incidence of growth faltering in rural Malawian children, the associations betwee...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-25
更新日期:2011-03-20 00:00:00
abstract:BACKGROUND:Meeting nutrient intake recommendations may demand substantial modifications in dietary patterns, and may increase diet cost. Incentives for modifying one's dietary intake that disregard prices are unlikely to be effective in the general population, especially among low-income strata, due to the high percent...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0466-y
更新日期:2019-07-20 00:00:00
abstract:BACKGROUND:Recent studies have shown that body image perception is an important factor in weight control and may be influenced by culture and ethnicity. The aim of the present study was to assess the relationship between immigrant status of the mother and weight status and body image perception of the child. METHODS:I...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-85
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:There is substantial evidence that low consumption of fruit and vegetables (FV) is a major risk factor for many chronic diseases. The aim of this study was to assess FV consumption and the variables that influence it among elderly individuals in Iran aged 60 and over. METHODS:This was a cross-sectional stud...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-9-2
更新日期:2010-01-13 00:00:00
abstract:BACKGROUND:Based on data obtained from pregnant women who participated in the Mothers and Children's Environmental Health (MOCEH) study in South Korea, we aimed to determine whether maternal intake of fruits and vegetables or vitamin C is associated with fetal and infant growth. METHODS:A total of 1138 Korean pregnant...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究
doi:10.1186/s12937-018-0410-6
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Increasing prevalence of obesity and overweight in the Western world, continue to be a major health threat and is responsible for increased health care costs. Dietary intervention studies show a strong positive association between saturated fat intake and the development of obesity and cardiovascular disease...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-53
更新日期:2011-05-18 00:00:00
abstract:BACKGROUND:Cachexia is a state of involuntary weight loss common to many chronic diseases. Experimental data, showing that cachexia is related to the enhancement of acute phase response reaction, led to the new definition of cachexia that included, aside from the principal criterion of weight loss, other "minor criteri...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-6
更新日期:2013-01-07 00:00:00
abstract:BACKGROUND:The plant stanol ester margarine Benecol is a functional food that has been shown to lower effectively serum total and LDL-cholesterol. The purpose of this post-marketing study is to characterize users of plant stanol ester margarine with and without cardiovascular disease. METHODS:A cohort of plant stanol ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-4-20
更新日期:2005-06-01 00:00:00
abstract::Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that is characterized by intermittent abdominal pain/discomfort, altered bowel habits and abdominal bloating/distension. This review aimed at presenting the recent developments concerning the role of diet in the pathophysiology and management...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-015-0022-3
更新日期:2015-04-14 00:00:00
abstract::Added sugar regulations and recommendations have been proposed by policy makers around the world. With no universal definition, limited access to added sugar values in food products and no analytical difference from intrinsic sugars, added sugar recommendations present a unique challenge. Average added sugar intake by...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-015-0114-0
更新日期:2015-12-12 00:00:00