Abstract:
BACKGROUND:Decreased ability of muscles to respond to anabolic stimuli is part of the underlying mechanism for muscle loss with aging. Previous studies suggest that substantial amounts of essential amino acids (EAA), whey protein and leucine are beneficial for stimulation of acute muscle protein synthesis in older adults. However, these studies supplied only proteins, and no bolus studies have been done with dairy products or supplements that contained also fat and carbohydrates besides proteins. The aim of this study was to evaluate whether a specifically designed nutritional supplement in older adults stimulates muscle protein synthesis acutely to a greater extent than a conventional dairy product. Moreover, the combined effect with resistance exercise was studied by using a unilateral resistance exercise protocol. METHODS:Utilizing a randomized, controlled, double blind study design, healthy older adults received a single bolus of a high whey protein, leucine-enriched supplement (EXP: 20 g whey protein, 3g total leucine, 150 kcal; n = 9) or an iso-caloric milk protein control ( CONTROL:6g milk protein; n = 10), immediately after unilateral resistance exercise. Postprandial mixed muscle protein fractional synthesis rate (FSR) was measured over 4h using a tracer infusion protocol with L-[ring-¹³C₆]-phenylalanine and regular blood and muscle sampling. RESULTS:FSR was significantly higher overall after EXP (0.0780 ± 0.0070%/h) vs CONTROL (0.0574 ± 0.0066%/h (EMM ± SE)) (p = 0.049). No interaction between treatment and exercise was observed (p = 0.519). Higher postprandial concentrations of EAA and leucine are possible mediating factors for the FSR response, while plasma insulin increase did not dictate the FSR response. Moreover, when the protein intake from the supplements was expressed per kg leg lean mass (LLM), a significant correlation was observed with resting postprandial FSR (r = 0.48, P = 0.038). CONCLUSIONS:Ingestion of a high whey protein, leucine-enriched supplement resulted in a larger overall postprandial muscle protein synthesis rate in healthy older subjects compared with a conventional dairy product. This acute effect is promising for long-term effects on parameters of muscle mass, strength and function in sarcopenic older people, which requires further study. TRIAL REGISTRATION:This trial is registered in the Dutch Trial Register under number NTR1823.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Luiking YC,Deutz NE,Memelink RG,Verlaan S,Wolfe RRdoi
10.1186/1475-2891-13-9subject
Has Abstractpub_date
2014-01-22 00:00:00pages
9issn
1475-2891pii
1475-2891-13-9journal_volume
13pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Dietary fibre food intake is related to a reduced risk of developing diabetes mellitus. However, the mechanism of this effect is still not clear. The aim of this study was to evaluate the effect of commercial fibre cereals on the rate of gastric emptying, postprandial glucose response and satiety in healthy ...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1475-2891-6-22
更新日期:2007-09-17 00:00:00
abstract::This paper aims to guide readers embarking on the complex literature in respect of childhood and adolescent obesity. It opens with a discussion of definitions of 'obesity' based on overall fat levels and the significance of fat distribution. This is followed by simple descriptions of the various techniques used to mea...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-6-32
更新日期:2007-10-26 00:00:00
abstract:BACKGROUND:Constipation is a common occurrence in formula-fed infants. The aim of this preliminary study was to evaluate the impact of a formula with high levels of lactose and magnesium, in compliance with the official regulations, on stool water content, as well as a parental assessment of constipation. MATERIALS AN...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-55
更新日期:2011-05-19 00:00:00
abstract:BACKGROUND:We conducted a single-arm clinical trial in institutionalized seniors, on the effects of high-dose vitamin D3-fortified bread daily intake (clinicaltrials.gov registration NCT00789503). METHODS:At 1 and 3 years after the dietary fortification was stopped, serum 25-hydroxyvitamin D (25(OH)D), parathyroid hor...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-12-137
更新日期:2013-10-11 00:00:00
abstract::Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that is characterized by intermittent abdominal pain/discomfort, altered bowel habits and abdominal bloating/distension. This review aimed at presenting the recent developments concerning the role of diet in the pathophysiology and management...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-015-0022-3
更新日期:2015-04-14 00:00:00
abstract:BACKGROUND:Healthier dietary patterns are generally more costly than less healthy patterns, but dietary costs may be more important for dietary quality in lower educated and ethnic minority groups. The aim of this study was to investigate the association between dietary costs and dietary quality and interactions with e...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0445-3
更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. METHODS:We included 100 overweight and obese adults (...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-017-0229-6
更新日期:2017-02-06 00:00:00
abstract:BACKGROUND:High fructose corn syrup (HFCS) sweetened soft drink intake has been linked with asthma in US high-schoolers. Intake of beverages with excess free fructose (EFF), including apple juice, and HFCS sweetened fruit drinks and soft drinks, has been associated with asthma in children. One hypothesis for this assoc...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-015-0097-x
更新日期:2015-10-16 00:00:00
abstract:BACKGROUND:Multiple micronutrient deficiencies, in particular iron deficiency anaemia (IDA) is a severe public health problem in Lao People's Democratic Republic (Lao PDR). Because of the practical difficulties encountered in improving the nutritional adequacy of traditional complementary foods and the limitations asso...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-129
更新日期:2011-11-24 00:00:00
abstract:BACKGROUND:An increasing number of studies in Western countries have shown that healthy dietary patterns may have a protective effect against cognitive decline and dementia. However, information on this relationship among non-Western populations with different cultural settings is extremely limited. We aim to examine t...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-017-0273-2
更新日期:2017-09-11 00:00:00
abstract:BACKGROUND:Tocotrienols (T3) and tocopherols (T), both members of the natural vitamin E family have unique biological functions in humans. T3 are detected in circulating human plasma and lipoproteins, although at concentrations significantly lower than α-tocopherol (α-T). T3, especially α-T3 is known to be neuropotecti...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-5
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:A number of studies have reported the association between dietary patterns and the risk of chronic kidney disease (CKD), however a consistent perspective hasn't been established to date. Herein, we conducted this systematic review and meta-analysis of observational studies to assess the association between d...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-020-00661-6
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND:Children in food-insecure families face increased barriers to meeting recommendations for fruit and vegetable consumption. Hospitals and pediatric healthcare institutions have attempted to alleviate food-insecurity through various internal programs like food prescriptions, yet little evidence for these progr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00616-x
更新日期:2020-09-09 00:00:00
abstract:BACKGROUND:This study examined the association of breakfast consumption, and the type of breakfast consumed, with body mass index (BMI; kg/m(2)) and prevalence rates and odds ratios (OR) of overweight/obesity among Canadian adults. These associations were examined by age group and sex. METHODS:We used data from non-pr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0151-3
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:To assess the nutrition knowledge of physicians on the basic effects of diet on blood lipids and lipoproteins. METHODS:Anonymous mailed dietary knowledge surveys to 6000 randomly selected physicians in the United States licensed in either Internal Medicine or Cardiology. RESULTS:Response rate: 16% (n = 639...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-2-19
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The objectives of this study are to construct a cultural adopted questionnaire for evaluation of consumer's attitudes toward functional foods among Iranian's population according to Theory of Planned Behavior (TPB) and to investigate the attitudes toward vitamin enriched foods (VEF). METHODS:Participants we...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00574-4
更新日期:2020-06-16 00:00:00
abstract:BACKGROUND AND AIM:Fenugreek is a herb that is widely used in cooking and as a traditional medicine for diabetes in Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of the effect of fenugreek intake o...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/1475-2891-13-7
更新日期:2014-01-18 00:00:00
abstract:BACKGROUND:Intra-articular hyaluronic acid represents a substantive addition to the therapeutic armamentarium in knee osteoarthritis. We examined the effect of dietary supplementation with a natural extract of chicken combs with a high content of hyaluronic acid (60%) (Hyal-Joint) (active test product, AP) on pain and ...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-7-3
更新日期:2008-01-21 00:00:00
abstract:BACKGROUND:Obesity is the most relevant overnutrition disease worldwide and is associated to different metabolic disorders such as insulin resistance and type-2 diabetes. Low glycemic load foods and diets and moderately high protein intake have been shown to reduce body weight and fat mass, exerting also beneficial eff...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2891-10-74
更新日期:2011-07-14 00:00:00
abstract:BACKGROUND:Dietary assessment methods that are user-friendly, simple, yet valid are of interest to both researchers and participants, particularly for use in disadvantaged settings, where language barriers and low levels of education are often present. We tested if parents taking photos of what children ate, using mobi...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00558-4
更新日期:2020-05-27 00:00:00
abstract::In this letter, we respond to the comments raised by Visaria et al. in their letter to the editor about the publication "Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES) 2011-2014". We have further adjusted for s...
journal_title:Nutrition journal
pub_type: 评论,信件
doi:10.1186/s12937-020-00620-1
更新日期:2020-09-11 00:00:00
abstract:BACKGROUND:Because the source of protein may play a role in its satiating effect, we investigated the effect of different proteins on satiation and short-term satiety. METHODS:Two randomized single-blind cross-over studies were completed. In the first study, we investigated the effect of a preload containing 20 g of c...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-139
更新日期:2011-12-23 00:00:00
abstract:BACKGROUND:Dietary assessment methods that can provide high quality data while limiting participant burden and resource requirements in epidemiological research are highly sought after and continue to evolve. The use of mobile phone technology in research has increased rapidly over the last decade and offers multiple a...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0315-4
更新日期:2018-01-09 00:00:00
abstract:BACKGROUND:We examined the effect of seasonality on the validity (ability to estimate the mean intake of a group and ranking ability) of nutrient intakes estimated with a comprehensive self-administered diet history questionnaire (DHQ) developed for the assessment of Japanese diets during the preceding one month, using...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-51
更新日期:2014-05-31 00:00:00
abstract:BACKGROUND:Dietary intake of vitamin K has been reported to reduce coronary artery calcification (CAC) and cardiovascular events. However, it is unknown whether supplemental menaquinone (MK)-4 can reduce CAC or arterial stiffness. To study the effect of MK-4 supplementation on CAC and brachial ankle pulse wave velocity...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0175-8
更新日期:2016-05-12 00:00:00
abstract:BACKGROUND:Information regarding dietary patterns associated with prediabetes in the Chinese population is lacking. The objective of the present study was to explore the association between major dietary patterns and the risk of prediabetes in a middle-aged Chinese population. METHODS:A total of 1761 participants (age...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00593-1
更新日期:2020-07-30 00:00:00
abstract::Public health policies, including in Europe, are considering measures and recommendations to limit the intake of added or free sugars. For such policies to be efficient and monitored, a precise knowledge of the current situation regarding sugar intake in Europe is needed. This review summarizes published or re-analyze...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-016-0225-2
更新日期:2017-01-21 00:00:00
abstract:BACKGROUND:Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults;...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00575-3
更新日期:2020-06-20 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-3-13
更新日期:2004-09-13 00:00:00
abstract:BACKGROUND:Our previous studies demonstrated that dietary supplementation with milk fat globule membrane (MFGM) combined with habitual exercise improved muscle strength by stimulating neuromuscular development in mice. This study aimed to demonstrate the beneficial effects of dietary MFGM supplementation plus regular e...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-015-0073-5
更新日期:2015-08-25 00:00:00