Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design.

Abstract:

BACKGROUND:Obesity leads to an increase in inflammation and insulin resistance. This study determined antioxidant activity of flaxseed and its role in inflammation and insulin resistance in obese glucose intolerant people. METHODS:Using a randomized crossover design, nine obese glucose intolerant people consumed 40 g ground flaxseed or 40 g wheat bran daily for 12 weeks with a 4-week washout period. Plasma inflammation biomarkers (CRP, TNF-α, and IL-6), glucose, insulin, and thiobaribituric acid reactive substance (TBARS) were measured before and after of each supplementation. RESULTS:Flaxseed supplementation decreased TBARS (p = 0.0215) and HOMA-IR (p = 0.0382). Flaxseed or wheat bran supplementation did not change plasma inflammatory biomarkers. A positive relationship was found between TBARS and HOMA-IR (r = 0.62, p = 0.0003). CONCLUSIONS:The results of the study weakly support that decreased insulin resistance might have been secondary to antioxidant activity of flaxseed. However, the mechanism(s) of decreased insulin resistance by flaxseed should be further determined using flaxseed lignan.

journal_name

Nutr J

journal_title

Nutrition journal

authors

Rhee Y,Brunt A

doi

10.1186/1475-2891-10-44

subject

Has Abstract

pub_date

2011-05-09 00:00:00

pages

44

issn

1475-2891

pii

1475-2891-10-44

journal_volume

10

pub_type

杂志文章,随机对照试验