Abstract:
:The number of individuals with age-related cognitive impairment is rising dramatically in the UK and globally. There is considerable interest in the general hypothesis that improving the diet of older people may slow the progression of cognitive decline. To date, there has been little attention given to the possible protective role of n-3 long-chain polyunsaturated fatty acids (n-3 LCPs) most commonly found in oily fish, in age-related loss of cognitive function. The main research hypothesis of this study is that an increased dietary intake of n-3 LCPs will have a positive effect on cognitive performance in older people in the UK. To test this hypothesis, a double-blind randomised placebo-controlled trial will be carried out among adults aged 70-79 years in which the intervention arm will receive daily capsules containing n-3 LCP (0.5 g/day docosahexaenoic acid and 0.2 g/day eicosapentaenoic acid) while the placebo arm will receive daily capsules containing olive oil. The main outcome variable assessed at 24 months will be cognitive performance and a second major outcome variable will be retinal function. Retinal function tests are included as the retina is a specifically differentiated neural tissue and therefore represents an accessible window into the functioning of the brain. The overall purpose of this public-health research is to help define a simple and effective dietary intervention aimed at maintaining cognitive and retinal function in later life. This will be the first trial of its kind aiming to slow the decline of cognitive and retinal function in older people by increasing daily dietary intake of n-3 LCPs. The link between cognitive ability, visual function and quality of life among older people suggests that this novel line of research may have considerable public health importance.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Dangour AD,Clemens F,Elbourne D,Fasey N,Fletcher AE,Hardy P,Holder GE,Huppert FA,Knight R,Letley L,Richards M,Truesdale A,Vickers M,Uauy Rdoi
10.1186/1475-2891-5-20subject
Has Abstractpub_date
2006-08-31 00:00:00pages
20issn
1475-2891pii
1475-2891-5-20journal_volume
5pub_type
杂志文章abstract:OBJECTIVE:Large preloads of protein and fat have been shown to lower glucose after a carbohydrate-rich meal in people with type 2 diabetes but add a considerable energy burden. Low calorie preloads [<5% of daily energy intake] have been tested in this study in people with prediabetes and with type 2 diabetes. RESEARCH...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-13-103
更新日期:2014-10-25 00:00:00
abstract:BACKGROUND:Pregnant women, neonates, and school-age children are vulnerable to iodine deficiency. The iodine contents in the environment (drinking water and household salt for cooking) vary by geographical location in China. The aim of this study was to assess the iodine status in vulnerable groups from different geogr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-0525-4
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Multiple sclerosis is a neurodegenerative disorder with a wide range in disease course severity. Many factors seem to be implicated in multiple sclerosis disease course, and diet has been suggested to play a role. Because limited data is present in the literature it was investigated whether variations in die...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-8-36
更新日期:2009-08-10 00:00:00
abstract:BACKGROUND:Information regarding dietary patterns associated with prediabetes in the Chinese population is lacking. The objective of the present study was to explore the association between major dietary patterns and the risk of prediabetes in a middle-aged Chinese population. METHODS:A total of 1761 participants (age...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00593-1
更新日期:2020-07-30 00:00:00
abstract:BACKGROUND:Dietary assessment methods that are user-friendly, simple, yet valid are of interest to both researchers and participants, particularly for use in disadvantaged settings, where language barriers and low levels of education are often present. We tested if parents taking photos of what children ate, using mobi...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00558-4
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults;...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00575-3
更新日期:2020-06-20 00:00:00
abstract:BACKGROUND:We have recently reported that short-term (21-day) dietary modification in accordance with a stringent vegan diet (i.e., a Daniel Fast) lowers blood lipids as well as biomarkers of oxidative stress. However, this work only involved measurements obtained in a fasted state. In the present study, we determined ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-11-16
更新日期:2012-03-21 00:00:00
abstract:BACKGROUND:Because the source of protein may play a role in its satiating effect, we investigated the effect of different proteins on satiation and short-term satiety. METHODS:Two randomized single-blind cross-over studies were completed. In the first study, we investigated the effect of a preload containing 20 g of c...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-139
更新日期:2011-12-23 00:00:00
abstract:BACKGROUND:Aging is a process associated with physiological changes such as in body composition, energy expenditure and physical activity. Data on energy and nutrient intake adequacy among elderly is important for disease prevention, health maintenance and program development. METHODS:This descriptive cross-sectional ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-8-19
更新日期:2009-05-04 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-128
更新日期:2011-11-21 00:00:00
abstract:BACKGROUND:This study examined the association of breakfast consumption, and the type of breakfast consumed, with body mass index (BMI; kg/m(2)) and prevalence rates and odds ratios (OR) of overweight/obesity among Canadian adults. These associations were examined by age group and sex. METHODS:We used data from non-pr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-016-0151-3
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:Parents who perceive common infant behaviors as formula intolerance-related often switch formulas without consulting a health professional. Up to one-half of formula-fed infants experience a formula change during the first six months of life. METHODS:The objective of this study was to assess discontinuance ...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2891-8-27
更新日期:2009-06-19 00:00:00
abstract:OBJECTIVE:To evaluate the association between the consumption of unhealthy foods in children under one year and the education level of the mothers, data obtained from participants of the II Survey on the prevalence of breastfeeding in the Brazilian capitals and the Federal District in 2008 was analyzed. METHODS:During...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-33
更新日期:2014-04-03 00:00:00
abstract::Several observational studies suggest an association between coffee intake and hip fracture risk. However, the results among them are inconsistent. We aimed to evaluate the association between coffee consumption and risk of hip fracture by performing a meta-analysis of prospective cohort studies. PubMed, Embase, and W...
journal_title:Nutrition journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12937-015-0025-0
更新日期:2015-04-18 00:00:00
abstract:BACKGROUND:Malnutrition is frequently observed in patients with pulmonary tuberculosis (TB). The present study aimed to examine the relationship between nutritional status using Malnutrition Universal Screening Tool (MUST) and the mortality of patients with pulmonary TB. METHODS:Fifty-seven patients with pulmonary TB ...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-42
更新日期:2013-04-08 00:00:00
abstract:BACKGROUND:A number of studies have reported the association between dietary patterns and the risk of chronic kidney disease (CKD), however a consistent perspective hasn't been established to date. Herein, we conducted this systematic review and meta-analysis of observational studies to assess the association between d...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-020-00661-6
更新日期:2021-01-08 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Dehydrated fruit and vegetable concentrates provide an accessible form of phytonutrient supplementation that may offer cardioprotective effects. This study assessed the effects of two blends of encapsulated juice powder concentrates (with and without added berry powders) on endothelial function...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2891-10-72
更新日期:2011-06-29 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Adequate nutrient intakes among women of reproductive age (WRA) are important determinants of maternal, neonatal and child health outcomes. However, data on dietary intake for WRA in Vietnam are lacking. This paper aimed to examine the adequacy and determinants of energy and macronutrient inta...
journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2891-12-126
更新日期:2013-09-12 00:00:00
abstract:BACKGROUND:Prebiotics are food ingredients, usually non-digestible oligosaccharides, that are selectively fermented by populations of beneficial gut bacteria. Endoxylanases, altering the naturally present cereal arabinoxylans, are commonly used in the bread industry to improve dough and bread characteristics. Recently,...
journal_title:Nutrition journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/1475-2891-11-36
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:We examined the effect of seasonality on the validity (ability to estimate the mean intake of a group and ranking ability) of nutrient intakes estimated with a comprehensive self-administered diet history questionnaire (DHQ) developed for the assessment of Japanese diets during the preceding one month, using...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-13-51
更新日期:2014-05-31 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the timing of introduction of complementary (solid) foods among infants in South Western Sydney, Australia, and describe the maternal and infant characteristics associated with very early introduction of solids. METHODS:Mother-infant dyads (n = 1035) were recruited in...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-0528-1
更新日期:2020-02-18 00:00:00
abstract::The benefits and risks of nutritional therapies in the prevention and management of infectious diseases in the developed world are reviewed. There is strong evidence that early enteral feeding of patients prevents infections in a variety of traumatic and surgical illnesses. There is, however, little support for simila...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2891-5-21
更新日期:2006-09-04 00:00:00
abstract:BACKGROUND:Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. METHODS:We included 100 overweight and obese adults (...
journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12937-017-0229-6
更新日期:2017-02-06 00:00:00
abstract:BACKGROUND:One of the driving factors of dietary overconsumption throughout the last decennia is the increase of food portion sizes. Larger portions induce higher daily energy intake, so reducing portion size may reduce intake of excess calories. However, real-life studies about the effects of portion size reduction ar...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0352-z
更新日期:2018-04-13 00:00:00
abstract:BACKGROUND:Children in food-insecure families face increased barriers to meeting recommendations for fruit and vegetable consumption. Hospitals and pediatric healthcare institutions have attempted to alleviate food-insecurity through various internal programs like food prescriptions, yet little evidence for these progr...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00616-x
更新日期:2020-09-09 00:00:00
abstract:OBJECTIVE:To evaluate the validity (study 1) and the reproducibility (study 2) of an interviewer-administered food frequency questionnaire (FFQ). METHOD:The FFQ was designed at Laval University and contains 91 items and 33 subquestions. STUDY 1: The FFQ was compared against a 3-day food record (2 week-days and 1 weeke...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-3-13
更新日期:2004-09-13 00:00:00
abstract:BACKGROUND:There is a promising outlook regarding the potential effect of spinach-derived thylakoids in the management of obesity and its associated metabolic disturbances. This research aimed to evaluate the effects of spinach-derived thylakoids supplementation combined with a calorie-restricted diet on anthropometric...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00601-4
更新日期:2020-08-11 00:00:00
abstract::Added sugar regulations and recommendations have been proposed by policy makers around the world. With no universal definition, limited access to added sugar values in food products and no analytical difference from intrinsic sugars, added sugar recommendations present a unique challenge. Average added sugar intake by...
journal_title:Nutrition journal
pub_type: 杂志文章,评审
doi:10.1186/s12937-015-0114-0
更新日期:2015-12-12 00:00:00
abstract:BACKGROUND:Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and early mortality. Excessive shortening of telomere is a marker of accelerated aging and can be influenced by oxidative stress and nutritional deficiency. Plasma n6:n3 polyunsaturated fatty acid...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00626-9
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:The increase in the burden of chronic diseases linked to the nutrition transition and associated dietary and lifestyle changes is of growing concern in south and east Mediterranean countries and adolescents are at the forefront of these changes. This study assessed dietary intake and association with socio-e...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-10-38
更新日期:2011-04-24 00:00:00