Abstract:
BACKGROUND:Sleep related breathing disorders (SRBD) are associated with increased morbidity and mortality and weight loss is recommended to overweight or obese patients with SRBD. However, maintenance of weight loss is difficult to achieve and strategies for weight loss maintenance is needed. Orlistat is a pharmacological agent that reduces the intestinal absorption of fat and may favour long-term weight maintenance. OBJECTIVE:To examine the change in body weight and dietary intake during a 1-year treatment with orlistat after an initial weight loss in obese subjects with SRBD. Furthermore, to explore the dietary determinants of weight maintenance during treatment with orlistat. METHODS:Men and women with SRBD aged 32-62 years (n=63) participated in a 3-month dietary intervention to increase intake of vegetables and fruit. After an initial weight loss of 3.4 kg they achieved a mean body mass index of 34.3±4.7 kg/m2. Subsequently they were treated with orlistat for 1 year. During this year, dietary and behavioural interventions to attain weight loss were provided in the course of 14 group sessions. Dietary intake, energy density and food choices were assessed with a food frequency questionnaire before and after orlistat treatment. RESULTS:With orlistat, body weight decreased by a mean of 3.5 kg (95% CI 1.5, 5.5). The dietary E% from saturated fat, intake of fatty dairy products and energy density increased after 1 year while intakes of oils, fish and vegetables decreased (all P<0.05). After multivariate adjustments, weight loss was associated with E% protein (R2adj=0.19 [95% CI 0.10, 0.46]), and inversely associated with E% saturated fat (R2adj=0.20 [95% CI 0.12, 0.47]) and fatty dairy products (R2adj=0.23 [95% CI 0.12, 0.49]). CONCLUSIONS:Orlistat induced further weight loss, but dietary compliance declined with time. Increasing dietary protein and restricting saturated fat and fatty dairy products may facilitate weight loss with orlistat.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Svendsen M,Tonstad Sdoi
10.1186/1475-2891-10-21subject
Has Abstractpub_date
2011-03-08 00:00:00pages
21issn
1475-2891pii
1475-2891-10-21journal_volume
10pub_type
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更新日期:2020-02-18 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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doi:10.1186/1475-2891-9-67
更新日期:2010-12-19 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-07-25 00:00:00
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更新日期:2007-09-19 00:00:00
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pub_type: 杂志文章
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更新日期:2018-02-12 00:00:00
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pub_type: 杂志文章
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更新日期:2012-05-03 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-6-29
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-06-16 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-020-00626-9
更新日期:2020-10-30 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-02-06 00:00:00