Abstract:
BACKGROUND:Gene-environment studies demonstrate variability in nutrient requirements depending upon individual variations in genes affecting nutrient metabolism and transport. This study investigated whether the inclusion of genetic information to personalize a patient's diet (nutrigenetics) could improve long term weight management. METHODS:Patients with a history of failures at weight loss were offered a nutrigenetic test screening 24 variants in 19 genes involved in metabolism. 50 patients were in the nutrigenetic group and 43 patients attending the same clinic were selected for comparison using algorithms to match the characteristics: age, sex, frequency of clinical visits and BMI at initial clinic visit. The second group of 43 patients did not receive a nutrigenetic test. BMI reduction at 100 and > 300 days and blood fasting glucose were measured. RESULTS:After 300 days of follow-up individuals in the nutrigenetic group were more likely to have maintained some weight loss (73%) than those in the comparison group (32%), resulting in an age and gender adjusted OR of 5.74 (95% CI 1.74-22.52). Average BMI reduction in the nutrigenetic group was 1.93 kg/m2(5.6% loss) vs. an average BMI gain of 0.51 kg/m2(2.2% gain) (p < 0.023). Among patients with a starting blood fasting glucose of > 100 mg/dL, 57% (17/30) of the nutrigenetic group but only 25% (4/16) of the non-tested group had levels reduced to < 100 mg/dL after > 90 days of weight management therapy (OR for lowering glucose to < 100 mg/dL due to diet = 1.98 95%CI 1.01, 3.87, p < 0.046). CONCLUSION:Addition of nutrigenetically tailored diets resulted in better compliance, longer-term BMI reduction and improvements in blood glucose levels.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Arkadianos I,Valdes AM,Marinos E,Florou A,Gill RD,Grimaldi KAdoi
10.1186/1475-2891-6-29subject
Has Abstractpub_date
2007-10-18 00:00:00pages
29issn
1475-2891pii
1475-2891-6-29journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Preterm birth is the leading cause of death in children under five. A recent Cochrane review found a 42% reduction in early preterm birth (< 34 weeks' gestation) and 11% reduction in preterm birth (< 37 weeks' gestation) with omega-3 fatty acid supplementation. To assist in the development of implementation ...
journal_title:Nutrition journal
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Nutrition journal
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journal_title:Nutrition journal
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journal_title:Nutrition journal
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doi:10.1186/1475-2891-10-135
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更新日期:2013-06-16 00:00:00
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更新日期:2020-05-27 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章,评审
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更新日期:2017-01-21 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-6
更新日期:2013-01-07 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-018-0417-z
更新日期:2018-11-19 00:00:00
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journal_title:Nutrition journal
pub_type: 杂志文章
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/s12937-019-0445-3
更新日期:2019-03-28 00:00:00