Abstract:
BACKGROUND:The association between serum selenium levels and type 2 diabetes mellitus (T2DM) is controversial. We performed a systematic review and non-linear dose-response meta-analysis of observational studies to investigate the association in the present study. METHODS:A comprehensive literature search was conducted using MEDLINE and EMBASE databases. A pooled odds ratio (OR) and related 95 % confidence interval (95 % CI) for T2DM between the highest and lowest serum selenium categories, and a non-linear dose-response relationship between selenium and T2DM were estimated. RESULTS:A total of five studies (of 13,460 participants) were identified as meeting the inclusion criteria. The pooled OR indicated that there was a significantly higher prevalence of T2DM in the highest category of blood selenium compared with the lowest (OR = 1.63, 95 % CI: 1.04-2.56, P = 0.033). Moreover, a significant non-linear dose-response relationship was observed between serum selenium levels and T2DM (P < 0.001). Serum selenium levels were positively associated with T2DM in populations with relatively low serum selenium levels (<97.5 μg/l) and those with high serum selenium levels (>132.5 μg/l). CONCLUSIONS:The positive association between serum selenium levels and T2DM existed in populations with relatively low levels and high levels of serum selenium, indicating a likely U-shaped non-linear dose-response relationship between serum selenium and T2DM.
journal_name
Nutr Jjournal_title
Nutrition journalauthors
Wang XL,Yang TB,Wei J,Lei GH,Zeng Cdoi
10.1186/s12937-016-0169-6subject
Has Abstractpub_date
2016-05-04 00:00:00pages
48issue
1issn
1475-2891pii
10.1186/s12937-016-0169-6journal_volume
15pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:The extent to which psychosocial and diet behavior factors affect dietary self-report remains unclear. We examine the contribution of these factors to measurement error of self-report. METHODS:In 450 postmenopausal women in the Women's Health Initiative Observational Study doubly labeled water and urinary n...
journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-12-63
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abstract:BACKGROUND:To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada. METHODS:A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, ...
journal_title:Nutrition journal
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journal_title:Nutrition journal
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
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journal_title:Nutrition journal
pub_type: 杂志文章,随机对照试验
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doi:10.1186/s12937-015-0097-x
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journal_title:Nutrition journal
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journal_title:Nutrition journal
pub_type: 杂志文章
doi:10.1186/1475-2891-2-15
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journal_title:Nutrition journal
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pub_type: 临床试验,杂志文章
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pub_type: 信件
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journal_title:Nutrition journal
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Nutrition journal
pub_type: 杂志文章
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