Abstract：
:Recognition and treatment of comorbid chronic psychotic symptoms in post-traumatic stress disorder (PTSD) has become of increasing clinical interest. Altered dopamine beta-hydroxylase (DBH) activity has been reported in mood disorders. Plasma DBH is reduced in major depression with psychosis and elevated in bipolar disorder with psychosis compared with their respective non-psychotic diagnostic groups. DBH is likely a trait marker with interindividual variations secondary to genetic polymorphism. We therefore evaluated DBH activity in PTSD patients with and without psychotic features and compared these groups with age- and gender-matched control subjects. Vietnam combat veterans with PTSD (n = 19) (including patients with and without psychotic features) and normal control subjects (n = 22) had plasma DBH enzyme activity assayed photometrically. DBH was significantly higher in patients with PTSD with psychotic features than in patients without psychotic features (80.6 +/- 13.4 vs. 42.1 +/- 7.3 mM/min, P < 0.01) and was also higher than normal control subjects (46.12 +/- 4.93, P < 0.01). Plasma DBH activity may differentiate psychotic and non-psychotic subtypes of PTSD. The observed changes are, interestingly, opposite to those seen in psychotic depression but comparable to psychotic bipolar disorder. Since DBH is a genetic marker, this may reflect individual vulnerabilities to develop psychosis in the context of trauma.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hamner MB,Gold PBdoi
10.1016/s0165-1781(98)00002-xsubject
Has Abstractpub_date
1998-02-27 00:00:00pages
175-81issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(98)00002-Xjournal_volume
77pub_type
杂志文章abstract：:Dewan asserted 20 years ago that a bedside light could shorten and regularize the menstrual cycle among women with long and irregular menstrual patterns. To replicate this, seven volunteers slept with a 100-watt bulb by the bedside from days 13-17 of their menstrual cycles, while nine controls similarly used a dim red...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90067-f
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abstract：:Haloperidol and reduced haloperidol plasma concentrations were measured in age-matched Chinese and non-Chinese patients (n = 32). Steady-state plasma concentrations were obtained 10-12 hours after the bedtime dose. Haloperidol and reduced haloperidol concentrations were measured by liquid chromatography and radioimmun...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90170-4
更新日期：1989-10-01 00:00:00
abstract：:Attention-deficit hyperactivity disorder is a common finding in school children. Because it was suggested to be related to frontal lobe dysfunction, we hypothesized that brain activation would be altered during an event-related color-word matching Stroop task in comparison to a healthy control group. Twelve medication...
journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(98)00015-8
更新日期：1998-06-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02802-1
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.001
更新日期：2017-06-01 00:00:00
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2016-04-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2012-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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doi：10.1016/0165-1781(88)90001-7
更新日期：1988-02-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.psychres.2015.09.001
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-12-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.04.004
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journal_title：Psychiatry research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Psychiatry research
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更新日期：2008-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.01.006
更新日期：2005-04-15 00:00:00
abstract：:The Unified Biosocial Theory of Personality developed by Cloninger has been applied in different cultures. Distribution by age and sex of the Temperament and Character Inventory (TCI) dimensions were assessed cross-culturally for samples in Spain and the USA. Three non-clinical samples were included: i) 404 participan...
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更新日期：2011-04-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1986-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.07.004
更新日期：2011-03-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.08.036
更新日期：2013-12-30 00:00:00
