Abstract：
:The neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) maps to the bipolar susceptibility locus on chromosome 8p21-22. Given the biological role of the neuronal nicotinic acetylcholine receptors and the substantial comorbidity of nicotine dependence in psychiatric disorders, the CHRNA2 gene is a plausible candidate gene for bipolar disorder (BPD). We tested the hypothesis that variations in the CHRNA2 gene confer susceptibility to bipolar I disorder in a case-control association study. Genotypes of one amino acid substitution polymorphism (Ala125Thr) and five non-coding variations across the CHRNA2 gene were obtained from 345 unrelated bipolar I patients and 273 control samples. Genotypes and allele frequencies were compared between groups using chi-square contingency analysis. Linkage disequilibrium (LD) between markers was calculated, and estimated haplotype frequencies were compared between groups. We observed no statitistically significant difference in genotype and allele frequencies for all six variations between bipolar patients and controls, but we did demonstrate strong LD throughout the gene. Haplotype analysis showed that no combinations of alleles were associated with illness. Our results suggest that common variations in the CHRNA2 gene are unlikely to confer susceptibility to BPD in this sample. Further studies are required to elucidate the susceptibility locus for BPD on chromosome 8p21-22.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Lohoff FW,Ferraro TN,McNabb L,Schwebel C,Dahl JP,Doyle GA,Buono RJ,Berrettini WHdoi
10.1016/j.psychres.2005.04.004subject
Has Abstractpub_date
2005-06-30 00:00:00pages
171-7issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(05)00118-6journal_volume
135pub_type
杂志文章abstract：:Unhealthy behaviors and physical morbidity are more common among trauma survivors, especially those who suffer from posttraumatic stress disorder (PTSD). This study looked at the underexplored relationships between parental PTSD, unhealthy behaviors and aging of trauma survivors' offspring. Dyads of parents (mean age ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.060
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To examine the construct validity of the 9 item Traumatic Events Questionnaire (TEQ) and to evaluate the extent to which experiences of trauma assessed using the TEQ are associated with symptoms of psychiatric disorders among 3342 pregnant women in Lima, Peru. METHODS:Symptoms of depression were assessed usi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.016
更新日期：2017-11-01 00:00:00
abstract：:Only few studies addressing the biological background of adjustment disorder (AD) exist. We examined the psychophysiological correlates indicative of autonomic regulation in AD. Heart rate variability (HRV), skin conductance, skin temperature, electromyography, and respiration were measured during serial stress tasks ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.065
更新日期：2018-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(90)90007-s
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.03.035
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：
更新日期：1997-02-07 00:00:00
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1997-05-16 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psychres.2013.08.045
更新日期：2013-12-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.08.008
更新日期：2013-01-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.07.008
更新日期：2011-09-30 00:00:00
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journal_title：Psychiatry research
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doi：10.1016/0165-1781(92)90005-n
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.01.012
更新日期：2011-05-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.04.008
更新日期：2009-11-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.12.006
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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pub_type： 杂志文章,meta分析,评审
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更新日期：2012-03-31 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2014-12-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.031
更新日期：2017-07-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2006-11-22 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-05-20 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(99)00098-0
更新日期：1999-12-20 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2001-12-15 00:00:00
