Abstract：
:The increases that occur in plasma prolactin (PRL) levels after i.m. administration of 5 mg of haloperidol (the HAL test) provide information about the responsivity of D2 dopamine receptors in the hypothalamus-hypophysis, and may be a measure of their occupancy during the neuroleptic treatment of schizophrenic patients. We studied these responses during treatment with haloperidol (doses 7.5-60 mg daily, mean = 20.6) in 12 male schizophrenic patients who did not have a satisfactory therapeutic response to the drug, and the test was repeated 6 weeks later, after the patients were switched to therapy with the atypical neuroleptic risperidone (8-16 mg daily, mean = 11.7). After the institution of risperidone treatment, the total score on the Brief Psychiatric Rating Scale (BPRS) fell by 38% (from a mean score of 47.2 to 29.3). BPRS subscale scores for positive, negative, and general symptoms were reduced by 38, 35, and 40%, respectively. Moderate PRL responses to the HAL test were found during haloperidol treatment and no responses at all during treatment with risperidone. Baseline PRL increased significantly from a mean of 35.0 (S.D. = 16.0) to a mean of 55.7 ng/ml plasma (S.D. = 19.6). This high potency of risperidone to increase PRL levels cannot be explained by the serotonergic blocking activity of the drug, and seems not to be restricted to its D2 receptor blocking capacity.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Markianos M,Hatzimanolis J,Lykouras Ldoi
10.1016/s0165-1781(99)00098-0subject
Has Abstractpub_date
1999-12-20 00:00:00pages
115-22issue
2eissn
0165-1781issn
1872-7123pii
S0165-1781(99)00098-0journal_volume
89pub_type
杂志文章abstract：:Psychiatric neuroimaging techniques are likely to improve understanding of the brain in health and disease, but studies tend to be small, based in one imaging centre and of unclear generalisability. Multicentre studies have great appeal but face problems if functional magnetic resonance imaging (fMRI) data from differ...
journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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doi：10.1016/j.psychres.2019.01.035
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(96)02961-7
更新日期：1997-03-03 00:00:00
abstract：:This study examines sexual behavior, serotonin turnover in the central nervous system, and testosterone in free-ranging non-human primates. Study subjects were 33 young adult male rhesus macaques (Macaca mulatta) living in naturalistic social groups on a 475-acre South Carolina barrier island. Blood and cerebrospinal ...
journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1997-09-19 00:00:00
abstract：:Cultured fibroblasts were prepared from six normal controls, five DSM-III manic patients, and six DSM-III schizophrenic patients. Lithium (Li+) uptake, 24-hour Li+ ratios, and steady-state membrane potential were measured in these cell lines. The uptake of 10 mM Li+ reached maximum at 2 hours, with an intracellular co...
journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1988-06-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析,评审
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更新日期：2013-12-30 00:00:00
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journal_title：Psychiatry research
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doi：10.1016/j.psychres.2011.09.010
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.06.012
更新日期：2009-08-30 00:00:00
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2000-10-30 00:00:00
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.09.005
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pub_type： 临床试验,杂志文章
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更新日期：1988-04-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.015
更新日期：2014-08-15 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.05.006
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journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2018.12.095
更新日期：2019-02-01 00:00:00
abstract：:The need for closure (NFC), a desire for a firm answer and less ambiguity, has a key role in cognitive flexibility in typical development (TD) populations. This study investigated this motivational construct and its relation to cognitive inflexibility in autism spectrum disorder (ASD). Compared with individuals with T...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.057
更新日期：2019-01-01 00:00:00
abstract：:This study examined season-of-assessment differences in parent and child reports of depressive problems on well-validated instruments in 2009 U.S. children and adolescents, aged 6 to 18 years, from a nationally representative population survey. A parent completed the Child Behavior Checklist (CBCL) for each participan...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.07.011
更新日期：2009-12-30 00:00:00
abstract：:Previous studies framed a possible link of retinoic acid (RA) regulation in brain to autism spectrum disorders (ASD) etiology. The aim of this study was to measure serum levels of RA in relation to the degree of the severity of autism. Serum RA levels were measured by enzyme-linked immunosorbent assay (ELISA) colorime...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.08.091
更新日期：2018-11-01 00:00:00
