Abstract：
:Cultured fibroblasts were prepared from six normal controls, five DSM-III manic patients, and six DSM-III schizophrenic patients. Lithium (Li+) uptake, 24-hour Li+ ratios, and steady-state membrane potential were measured in these cell lines. The uptake of 10 mM Li+ reached maximum at 2 hours, with an intracellular concentration of approximately 15 mM. No significant difference in uptake was found among subject groups. Twenty-four hour Li+ (ratio of intracellular/extracellular Li+) ratios were determined by incubating the cell lines for 24 hours in the presence of 2 mM Li+. No significant difference was observed among groups; nor was there any significant correlation between the fibroblast 24-hour ratios and 24-hour in vitro ratios determined in donor red cells. The relationship between membrane potential and the 24 hour Li+ ratio in fibroblasts was determined. The average potential in these cell lines was -56 mV and was not affected by Li+ treatment. No correlation between the Li+ ratio and membrane potential was found.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hitzemann R,Kao L,Hirschowitz J,Garver D,Gruenstein Edoi
10.1016/0165-1781(88)90114-xsubject
Has Abstractpub_date
1988-06-01 00:00:00pages
337-44issue
3eissn
0165-1781issn
1872-7123pii
0165-1781(88)90114-Xjournal_volume
24pub_type
杂志文章abstract：:The absence of assessment tools incorporating different cultural models of mental illness is a major barrier to recruiting ethnic minorities into clinical trials, reducing generalisability of findings and potentially increasing disparities in access to evidence-based care. This study aimed to develop and validate a ne...
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journal_title：Psychiatry research
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更新日期：2011-05-31 00:00:00
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