Abstract：
:The antipsychotic effects of dopamine D2 receptor antagonists (neuroleptics) and the psychotomimetic effects of dopamine agonists suggest that a defect of the D2 receptor gene might be a factor in the etiology of schizophrenia. Fifteen families that contained several members suffering from schizophrenia were tested for linkage between the D2 receptor gene and schizophrenia. In addition, four flanking markers were tested. The mode of inheritance was assumed to be dominant. Five different models of the affection status, which ranged from a narrow to a broad definition of the affection status, were studied. Linkage analysis was carried out with dominant, recessive, and intermediate modes of transmission. Two-point and multipoint analyses between schizophrenia and the D2 receptor gene resulted in log-likelihood differences < -2 for all five models, and linkage between this candidate gene and schizophrenia was excluded. A mutation in the D2 receptor gene itself is therefore extremely unlikely to be related to a higher susceptibility to schizophrenia, at least in the present group of families.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hallmayer J,Maier W,Schwab S,Ertl MA,Minges J,Ackenheil M,Lichtermann D,Wildenauer DBdoi
10.1016/0165-1781(94)90111-2subject
Has Abstractpub_date
1994-08-01 00:00:00pages
203-15issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(94)90111-2journal_volume
53pub_type
杂志文章abstract：:This descriptive study of 55 outpatients with unipolar major depression compared placebo responders (n = 21) and placebo nonresponders (n = 34) with respect to demographic, diagnostic, history of illness and symptomatic features of the current episode of depression. Placebo responders were significantly more likely to...
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pub_type： 临床试验,杂志文章
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更新日期：1986-07-01 00:00:00
abstract：:Impairments in emotion recognition skills are a trans-diagnostic indicator of early mental health problems and may be responsive to intervention. We report on a randomized controlled trial of "Emotion-recognition-training" (ERT) versus treatment-as-usual (TAU) with N=195 mixed diagnostic children (mean age 10.52 years...
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pub_type： 杂志文章,随机对照试验
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abstract：:A significant association between anxiety and depersonalization has been found in healthy controls and psychiatric patients irrespective of underlying conditions. Although patients with depersonalization disorder (DPD) often have a history of severe anxiety symptoms, clinical observations suggest that the relation bet...
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更新日期：2006-12-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2005-04-30 00:00:00
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pub_type： 杂志文章
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更新日期：2014-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1993-10-01 00:00:00
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更新日期：2018-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1983-06-01 00:00:00
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更新日期：1999-02-22 00:00:00
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journal_title：Psychiatry research
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更新日期：2013-04-30 00:00:00
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更新日期：2013-09-30 00:00:00
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pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2011-05-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2014-01-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90011-6
更新日期：1994-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.10.001
更新日期：2016-12-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2018-03-01 00:00:00
abstract：:Patients with schizophrenia are affected more adversely than healthy controls by distracting conditions, due to their inability to adequately apportion attentional resources to targets or distractors. We attempted to re-evaluate the effects of distractors in 25 patients with chronic schizophrenia and in 12 controls. T...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.07.017
更新日期：2005-11-15 00:00:00
abstract：:The covid-19 pandemic has heavily burdened healthcare systems throughout the world. We performed a rapid systematic review to identify, assess and summarize research on the mental health impact of the covid-19 pandemic on HCWs (healthcare workers). We utilized the Norwegian Institute of Public Health's Live map of cov...
journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2014-12-30 00:00:00
abstract：:Family environmental variables are risk factors for recurrent courses of mood disorder in adolescents. The present study examined the association between parental expressed emotion (EE)-critical, hostile and/or emotionally overinvolved attitudes toward a concurrently ill offspring-and suicidal ideation in adolescents ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.02.013
更新日期：2014-05-15 00:00:00
