Abstract：
:Glucocorticoids are known to modulate memory functions, with elevated cortisol levels being associated with impaired declarative memory. This specific effect has been shown in several studies using pharmacological doses of cortisol. The present study was designed to assess the effects of stress-induced cortisol elevations on (1) the type of memory processing (encoding, consolidation and retrieval), and (2) on the emotional valence of the material under study. Sixteen healthy females were presented neutral and emotional material (words and paragraphs) before and after a stress challenge. Declarative memory was tested immediately after presentation and 24 h later (delayed recall). Delayed, but not immediate recall of the information presented after the stress challenge was significantly reduced compared with delayed recall of information presented before the stress challenge. In line with this, strong negative correlations were found for delayed recall of words and spatial memory presented after the challenge with post-stress cortisol levels, whereas no significant correlations were found between cortisol levels and delayed recall at day 1. These results suggest that stress-induced cortisol specifically affects long-term consolidation of declarative memories. These findings may have implications for understanding the effects of traumatic stress on memory functioning in patients with stress-related psychiatric disorders.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Elzinga BM,Bakker A,Bremner JDdoi
10.1016/j.psychres.2004.11.007subject
Has Abstractpub_date
2005-04-30 00:00:00pages
211-23issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(05)00023-5journal_volume
134pub_type
杂志文章abstract：:Quantitative electroencephalographic (QEEG) analyses are presented for a group of 90 subjects recovering from polysubstance abuse (median = 90 days abstinent) who preferentially used cocaine. QEEGs showed significant decreases from normal in both absolute and relative delta power and decreased theta power in both abso...
journal_title：Psychiatry research
pub_type： 杂志文章
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pub_type： 历史文章,杂志文章
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pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02496-j
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journal_title：Psychiatry research
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journal_title：Psychiatry research
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doi：10.1016/j.pscychresns.2004.07.006
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journal_title：Psychiatry research
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1986-07-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Psychiatry research
pub_type： 杂志文章
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