Abstract：
:The aim of this study is to investigate whether mismatch negativity (MMN) is associated with functional status or is a state-independent trait for schizophrenia. We assessed MMN in 26 patients with schizophrenia, 20 healthy subjects with high genetic loading, and 48 healthy controls. Repeated measures analysis of variance and Pearson׳s correlations were used to test the hypothesis that MMN is not state-independent. We found a significant main effect of group, indicating differences in the peak amplitudes of the MMN among the three groups. Post-hoc analyses revealed that schizophrenia patients showed a significant reduction in the peak amplitude of MMN, but subjects at high genetic risk and healthy controls did not. Additionally, significant correlations between Global Assessment of Functioning scores and MMN peak amplitude at Fz and Cz were found in patients with schizophrenia. These findings suggest that MMN may reflect current functional status rather than a genetic risk for schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Kim M,Kim SN,Lee S,Byun MS,Shin KS,Park HY,Jang JH,Kwon JSdoi
10.1016/j.pscychresns.2014.02.012subject
Has Abstractpub_date
2014-04-30 00:00:00pages
100-6issue
1-2eissn
0165-1781issn
1872-7123pii
S0925-4927(14)00054-7journal_volume
222pub_type
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