Abstract：
:In the present study we set out to explore the long-term clinical course of schizophrenia in a holistic manner by adopting sequence analysis. Our aim was to identify course types of illness by means of cluster analysis. The study was based on course and outcome data for 107 patients followed up over 134 months after first admission in the ABC Schizophrenia Study. Focusing on the main syndromes (positive, negative, depressive and unspecific symptoms) and their combinations we looked for similarities in individual illness courses using the 'optimal matching' method. A cluster analysis performed on the resulting similarity matrix yielded two main groups (a 'improving' and a 'chronic' group), which comprised a total of six different types of illness course. The course types differed in both quantitative (frequency of syndromes and syndrome combinations) and qualitative terms (clinical presentation, sequence of syndromes). Cluster membership was only rarely, but clearly associated with sociodemographic characteristics, treatment data and other illness variables.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
An der Heiden W,Häfner Hdoi
10.1016/j.psychres.2015.04.056subject
Has Abstractpub_date
2015-08-30 00:00:00pages
551-9issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(15)00342-Xjournal_volume
228pub_type
杂志文章abstract：:New methods for using ketamine in patients with propofol-electroconvulsive therapy-resistant depression (ECT-RD) are needed in the clinic. This study aimed to investigate the therapeutic efficacy of ketamine plus ECT in ECT-RD patients, along with the treatment-induced brain alterations. A total of 28 ECT-RD patients ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112907
更新日期：2020-05-01 00:00:00
abstract：:Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they pr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.11.001
更新日期：2010-09-30 00:00:00
abstract：:A widespread assumption in research and clinical practice is that cognitive reappraisal is a healthy and successful emotion regulation strategy, while expressive suppression is ineffective and has non-favourable consequences (e.g., decreased positive affect, higher physiological arousal). However, little is known abou...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.05.034
更新日期：2012-12-30 00:00:00
abstract：:A visual analogue scale to evaluate fatigue severity (VAS-F) was developed and tested in a sample of 75 healthy individuals and a sample of 57 patients undergoing medical evaluation for sleep disorders. The scale consists of 18 items related to fatigue and energy, has simple instructions, and is completed with minimal...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90027-m
更新日期：1991-03-01 00:00:00
abstract：:Evidence on mental illness stigma abounds yet little is known about public perceptions of intellectual disability. This study examined causal beliefs about intellectual disability and schizophrenia and how these relate to awareness of the condition and social distance. UK lay people aged 16+(N=1752), in response to vi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.06.019
更新日期：2016-09-30 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) is characterized by unwanted, intrusive and disturbing thoughts or images that cause anxiety and repetitive behaviours or mental acts to relieve these thoughts or images. Considering controversial aetiology of OCD and growing evidence for the role of inflammation in OCD, the aim of ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113065
更新日期：2020-08-01 00:00:00
abstract：:Light falling on the retina is converted into an electrical signal which stimulates serotonin synthesis. Previous studies described an increase of plasma and CNS serotonin levels after bright light exposure. Ghrelin and leptin are peptide hormones which are involved in the regulation of hunger/satiety and are related ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.05.068
更新日期：2015-10-30 00:00:00
abstract：:The pharmacokinetic properties of platelets make these vascular elements a potential and convenient model for serotoninergic neurons. Because we encountered several difficulties in preliminary platelet serotonin (5HT) uptake assays, we explored the influence of several assay factors on the parameters obtained. We foun...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(87)90051-5
更新日期：1987-09-01 00:00:00
abstract：:Animal models and clinical trials in humans suggest that probiotics can have an anxiolytic effect. However, no studies have examined the relationship between probiotics and social anxiety. Here we employ a cross-sectional approach to determine whether consumption of fermented foods likely to contain probiotics interac...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.04.023
更新日期：2015-08-15 00:00:00
abstract：:Religion and/or spirituality (R/S) can play a vital, multifaceted role in mental health. While beliefs about God represent the core of many psychiatric patients' meaning systems, research has not examined how internalized images of the divine might contribute to outcomes in treatment programs/settings that emphasize m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.05.003
更新日期：2017-08-01 00:00:00
abstract：:Verbal memory impairment in borderline personality disorder (BPD) is still a matter of debate. In this study we combine investigations of both, memory retrieval as well as underlying neural circuits in BPD. Functional magnetic resonance imaging (fMRI) was used to study regional brain activation in 18 right-handed fema...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2008.02.006
更新日期：2009-02-28 00:00:00
abstract：:The goal of this study was to assess integrity of the cingulum bundle in patients diagnosed with first episode schizophrenia, chronic schizophrenia, and matched controls as well as to determine the relationship between diffusion measures of cingulum bundle integrity and severity of patients' delusions of reference. Pa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.08.002
更新日期：2014-11-30 00:00:00
abstract：:Human corticotropin releasing hormone (h-CRH) was administered to 14 patients with major depression, after premedication with an overnight dose of 1.5 mg dexamethasone. Cortisol response, expressed as area under the time course curve (AUC), was significantly higher in the 14 patients than in a group of 13 age-matched ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90041-m
更新日期：1991-08-01 00:00:00
abstract：:Schizophrenia patients show a disconnection in amygdala-medial prefrontal cortex and autonomic arousal systems for processing fear. Concurrent functional magnetic resonance imaging [fMRI] and skin conductance recording were used to determine whether these disturbances are specific to fear, or present in response to ot...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.12.018
更新日期：2007-05-15 00:00:00
abstract：:Platelet monoamine oxidase (MAO) activity and intellectual level were examined in a large series of 1,129 18-year-old boys, selected from the general population. Personality traits were determined by means of selected subscales from several personality inventories such as the Zuckerman Sensation Seeking Scale, the Eys...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90134-3
更新日期：1984-05-01 00:00:00
abstract：:While research using Experience Sampling Methodology (ESM) suggests that, in general, contact with relatives or friends may be protective for psychotic experiences, contact with high-Expressed Emotion (high-EE) relatives can have adverse consequences for patients. This study investigated whether contact with high-EE r...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.060
更新日期：2016-11-30 00:00:00
abstract：:Male research subjects were administered placebo and three doses of d-amphetamine (5, 10, and 20 mg/70 kg of body weight) under double-blind conditions in a laboratory situation that provided both aggressive and nonaggressive response options. The nonaggressive response was button pressing maintained by the presentati...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(87)90030-8
更新日期：1987-07-01 00:00:00
abstract：:The primary aim of the present study was to assess the possible associations between dopaminergic, serotonergic, and glutamatergic system-related genes and adverse events after antipsychotic treatment in paranoid schizophrenia patients. The second aim of the study was to compare the intensity of these symptoms between...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2014.05.039
更新日期：2014-10-30 00:00:00
abstract：:Schizophrenia patients have well-established deficits in facial emotion perception, which contribute to their poor social functioning. A number of studies have related these deficits to a differential dysfunction in the magnocellular (M) versus parvocellular (P) visual pathway. We assessed 35 schizophrenia patients an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.031
更新日期：2017-07-01 00:00:00
abstract：:The DSM-IV describes pathological gambling as a chronic condition with an insidious course. However, several extant studies characterize pathological and problem gambling as fluctuating over time. The present analyses expand on previous reports by evaluating changes in pathological gambling symptoms across the lifetim...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.05.015
更新日期：2007-07-30 00:00:00
abstract：:Decreased central serotonergic activity has been associated with aggressive behavior in humans and animals. Whether or not this phenomenon is related to current aggression or to aggressive tendency is debatable. [3H]paroxetine binding in blood platelets represents the activity of serotonin peripheral binding sites. We...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00116-5
更新日期：2000-04-24 00:00:00
abstract：:We have previously reported that the activity in platelets of the important antioxidant enzyme glutathione peroxidase (GPx) is inversely correlated with computed tomographic (CT) measures of brain atrophy in a population of patients with chronic schizophrenia, suggesting that low GPx may be a vulnerability factor in t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90103-c
更新日期：1990-01-01 00:00:00
abstract：:The main goal of this study it is explore the psychopathological differences between IPD and SIPD in a sample of 125 adults with a lifetime diagnosis of cocaine disorder recruited from treatment setting and through street contacts. A secondary analysis of six cross-sectional studies was conducted between 2000 and 2010...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.05.043
更新日期：2016-08-30 00:00:00
abstract：:A notable number of young adults struggle to control impulsive behavior, resulting in impairment and distress. Assessments of problematic sexual behavior (PSB) have noted clinical differences relative to other populations, but neurocognitive findings have varied. This analysis assesses the clinical presentation and ne...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.09.044
更新日期：2016-12-30 00:00:00
abstract：:Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for de...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.psychres.2016.11.014
更新日期：2017-01-01 00:00:00
abstract：:Seventy volunteers had 3 nights of sleep recordings during a period of marital separation, and 61 returned for repeat studies 1 year later. At that time, the divorce was final for 42. Forty of the volunteers were depressed when first screened, and 30 were not. Initially all those undergoing marital separation had less...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90088-7
更新日期：1991-12-01 00:00:00
abstract：:Adult attention deficit hyperactivity disorder (ADHD) is frequently associated with borderline personality disorder (BPD). As both disorders share some core clinical features they are sometimes difficult to distinguish from one another. The present work aimed to investigate differences in the expression of impulsivity...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.03.006
更新日期：2014-06-30 00:00:00
abstract：:In a review of the current literature, we identified (1)H MRS studies of major depressive disorder (MDD) that examined the metabolites N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), glutamate/glutamine/gamma-aminobutyric acid-GABA (Glx), and creatine (Cr). Separate meta-analyses comparing adult and pediatr...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.pscychresns.2005.12.004
更新日期：2006-06-30 00:00:00
abstract：:Family environment is a pathogenic factor of borderline personality disorder (BPD). However, the personality traits of patients with BPD and their parents have never been assessed using the same instrument and then examined for relationships. In the present study, we explored the temperament and character traits of BP...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.10.010
更新日期：2009-01-30 00:00:00
abstract：:The purposes of this study were to investigate the mediating effect of smartphone addiction and depression on neuroticism and quality of life. Self-reported measures of neuroticism, smart-phone addiction, depression, and quality of life were administered to 722 Chinese university students. Results showed smartphone ad...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.074
更新日期：2017-12-01 00:00:00
