Abstract：
:Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for developing a psychosis. Structural Equation Modeling was used to examine the effect of childhood adversity on depression, anxiety, transition to psychosis and overall functioning at 4-year follow-up. In addition, we evaluated economic costs of childhood adversity in terms of health care use and productivity loss. Data pertain to 105 UHR participants of the Dutch Early Detection and Intervention Evaluation (EDIE-NL). Physical abuse was associated with higher depression rates (b=0.381, p=0.012) and lower social functional outcome (b=-0.219, p=0.017) at 4-year follow-up. In addition, emotional neglect was negatively associated with social functioning (b=-0.313, p=0.018). We did not find evidence that childhood adversity was associated with transition to psychosis, but the experience of childhood adversity was associated with excess health care costs at follow-up. The data indicate long-term negative effects of childhood adversity on depression, social functioning and health care costs at follow-up in a sample of UHR patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Kraan TC,Ising HK,Fokkema M,Velthorst E,van den Berg DPG,Kerkhoven M,Veling W,Smit F,Linszen DH,Nieman DH,Wunderink L,Boonstra N,Klaassen RMC,Dragt S,Rietdijk J,de Haan L,van der Gaag Mdoi
10.1016/j.psychres.2016.11.014subject
Has Abstractpub_date
2017-01-01 00:00:00pages
55-62eissn
0165-1781issn
1872-7123pii
S0165-1781(16)30872-1journal_volume
247pub_type
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