A commingling analysis of platelet monoamine oxidase activity.

Abstract:

:The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity being controlled by a single major locus with a gene frequency of 0.02 for high-MAO activity. Accordingly, it is unlikely that such a locus could serve as a genetic marker for a disorder which is associated with low activity. However, this finding does not rule out the possibility that MAO activity is an associated risk factor in disease.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Rice J,McGuffin P,Shaskan EG

doi

10.1016/0165-1781(82)90069-5

subject

Has Abstract

pub_date

1982-12-01 00:00:00

pages

325-35

issue

3

eissn

0165-1781

issn

1872-7123

pii

0165-1781(82)90069-5

journal_volume

7

pub_type

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