Ketamine plus propofol-electroconvulsive therapy (ECT) transiently improves the antidepressant effects and the associated brain functional alterations in patients with propofol-ECT-resistant depression.

Abstract:

:New methods for using ketamine in patients with propofol-electroconvulsive therapy-resistant depression (ECT-RD) are needed in the clinic. This study aimed to investigate the therapeutic efficacy of ketamine plus ECT in ECT-RD patients, along with the treatment-induced brain alterations. A total of 28 ECT-RD patients were intravenously injected with ketamine six times and treated with propofol-ECT six times alternately within two weeks. The Hamilton Depression Scale was used to assess the treatment effect. Global functional connectivity density (gFCD) and functional connectivity strength (FCS) were used to evaluate functional brain alterations. As compared with the propofol-ECT treatment group, the addition of ketamine could improve the therapeutic outcomes in patients with ECT-RD. The treatment increased gFCD in the left temporal and subgenual anterior cingulated cortex. Simultaneously, the treatment decreased FCS within the default mode network. Although increased functional connectivity could be sustained for 10 days, the clinical effect was only sustained 7 days, indicating that the clinical effect and functional brain alterations were disjointed. Ketamine plus propofol-ECT can obviously improve the effects of propofol-ECT in ECT-RD patients. However, the effect is limited in 7 days, suggesting the benefit is short-term.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Zhang J,Tian H,Li J,Ji S,Chen S,Zhu J,Jiang D,Wang L,Li G,Chen M,Wang W,Lin X,Zhuo C

doi

10.1016/j.psychres.2020.112907

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

112907

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(19)32442-4

journal_volume

287

pub_type

杂志文章
  • Social adjustment could be associated with the serotonin transporter gene in remitted patients with mood disorders and healthy subjects.

    abstract::We investigated the serotonin transporter gene (5-HTTLPR) in the functioning of euthymic patients with mood disorders (n=285) and healthy controls (n=94). The 5-HTTLPR genotype showed marginal associations with working, familial and social adjustment, with marked differences between controls and patients. Because of t...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2005.01.006

    authors: Serretti A,Mandelli L,Lorenzi C,Smeraldi E

    更新日期:2005-04-15 00:00:00

  • Platelet serotonin uptake: methods and strain differences.

    abstract::The pharmacokinetic properties of platelets make these vascular elements a potential and convenient model for serotoninergic neurons. Because we encountered several difficulties in preliminary platelet serotonin (5HT) uptake assays, we explored the influence of several assay factors on the parameters obtained. We foun...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(87)90051-5

    authors: Codd EE,Walker RF

    更新日期:1987-09-01 00:00:00

  • Simultaneous pattern of rCBF and rCMRGlu in continuation ECT: case reports.

    abstract::This report presents the simultaneous pattern of cerebral blood flow and cerebral glucose metabolism in two patients with a major depressive disorder who were undergoing continuation ECT. The regional cerebral blood flow and regional cerebral metabolic rate of these patients were imaged using double isotope 18F-FDG an...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/s0925-4927(03)00077-5

    authors: Conca A,Prapotnik M,Peschina W,König P

    更新日期:2003-11-30 00:00:00

  • Behavioral engagement level, variability, and diurnal rhythm as a function of bright light in bipolar II seasonal affective disorder: an exploratory study.

    abstract::Six patients with bipolar II seasonal affective disorder (SAD) and seven normal control subjects rated their moods in winter at six fixed times each week-day during 1 week of dim and 2 weeks of bright light. The scales rated represent the mood dimension specifically associated with depression, a dimension here called ...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章

    doi:10.1016/0165-1781(92)90129-q

    authors: Krauss SS,Depue RA,Arbisi PA,Spoont M

    更新日期:1992-08-01 00:00:00

  • Polyunsaturated fatty acid composition and childhood adversity: Independent correlates of depressive symptom persistence.

    abstract::Childhood experiences, personality, and polyunsaturated essential fatty acid (PUFA) composition have all been shown to affect the likelihood of depressive symptoms. Few studies have addressed relationships between these factors in their influence on the occurrence or course of depressive symptoms. The following analys...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2017.06.036

    authors: Coryell WH,Langbehn DR,Norris AW,Yao JR,Dindo LN,Calarge CA

    更新日期:2017-10-01 00:00:00

  • Personality traits in the differentiation of major depressive disorder and bipolar disorder during a depressive episode.

    abstract::The aim of this study was to determine the differences in personality traits between individuals with Major Depressive Disorder (MDD) and Bipolar Disorder (BD) during a depressive episode, when it can be hard to differentiate them. Data on personality traits (NEO-FFI), mental disorders (Mini International Neuropsychia...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2015.12.029

    authors: Araujo JMG,Passos MBD,Molina ML,da Silva RA,Souza LDM

    更新日期:2016-02-28 00:00:00

  • Cortisol levels before and after cognitive behavioural therapy in patients with eating disorders reporting childhood abuse: A follow-up study.

    abstract::The etiopathogenesis of eating disorders (EDs) is complex and still not well understood. Biological, psychological and environmental factors (e.g. childhood abuse) have all been considered to be involved in the onset and the persistence of EDs. The hypothalamic-pituitary-adrenal (HPA) axis is a relevant biological fac...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2019.03.046

    authors: Lelli L,Castellini G,Cassioli E,Monteleone AM,Ricca V

    更新日期:2019-05-01 00:00:00

  • Behavior Problems Inventory (BPI): Psychometric characteristics of an instrument for routine assessment of persons with psychoses and related disorders.

    abstract::This study explores the psychometric characteristics of the Behavior Problems Inventory (BPI), an instrument for routine clinical assessment of behavior problems in outpatients with psychosis based on information provided by key family informants. Six hundred and twenty-one patients diagnosed with psychosis and bipola...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.03.051

    authors: Vázquez Morejón AJ,Vázquez-Morejón R,Bellido Zanin G

    更新日期:2018-12-01 00:00:00

  • T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients.

    abstract::It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-beta1), has been shown to modulate the production of Th1 and...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2004.08.005

    authors: Kim YK,Myint AM,Lee BH,Han CS,Lee SW,Leonard BE,Steinbusch HW

    更新日期:2004-12-30 00:00:00

  • Associations between depression subtypes and substance use disorders.

    abstract::Evaluating whether certain subtypes of Major Depressive Disorder (MDD) are more strongly associated with Substance Use Disorders (SUDs) may help clarify reasons for MDD-SUD relations. Therefore, this study compared DSM-IV-defined non-atypical/non-melancholic depression (undifferentiated depression; n=365), atypical de...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2007.10.014

    authors: Leventhal AM,Francione Witt C,Zimmerman M

    更新日期:2008-10-30 00:00:00

  • A structural test of the Integrated Motivational-Volitional model of suicidal behaviour.

    abstract::Suicidal behaviours are highly complex, multi-determined phenomena. Despite this, historically research has tended to focus on bivariate associations between atheoretical demographic and/or psychiatric factors and suicidal behaviour. The aim of this study was to empirically test the Integrated Motivational-Volitional ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.03.023

    authors: Dhingra K,Boduszek D,O'Connor RC

    更新日期:2016-05-30 00:00:00

  • Discerning the latent structure of hypothetical psychosis proneness through admixture analysis.

    abstract::The application of psychometric procedures to a normal population sample to detect individuals with increased liability for schizophrenia is a useful methodological adjunct to the traditional genetic high-risk strategy. A necessary and reasonable step in the process of establishing the utility of a viable psychometric...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(90)90041-3

    authors: Lenzenweger MF,Moldin SO

    更新日期:1990-09-01 00:00:00

  • Platelet imipramine binding in endogenous depressed patients and controls: relationship to platelet MAO and 5HT uptake during successful imipramine treatment.

    abstract::Platelet imipramine binding was measured in 25 unmedicated depressed patients and 25 age- and sex-matched healthy controls. In the patients, the measurement was repeated after 3 weeks and 2 months of imipramine treatment leading to clinical recovery. No significant differences in imipramine binding were found between ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(90)90040-c

    authors: Quintana J

    更新日期:1990-09-01 00:00:00

  • The concomitant use of second-generation antipsychotics and long-term antiretroviral therapy may be associated with increased cardiovascular risk.

    abstract::To study the effect of concurrent use of second-generation antipsychotics (SGAs) on metabolic syndrome (MetS) components conferring increased cardiovascular risk in a sample of human immunodeficiency virus (HIV)-infected adults taking antiretroviral therapy (ART). A retrospective study of participants consecutively re...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2014.04.015

    authors: Ferrara M,Umlauf A,Sanders C,Meyer JM,Allen McCutchan J,Duarte N,Hampton Atkinson J,Grant I,Ellis RJ,CHARTER Group.

    更新日期:2014-08-15 00:00:00

  • The role of unhelpful metacognitive beliefs in psychosis: Relationships with positive symptoms and negative affect.

    abstract::The Self-Regulatory Executive Function (s-REF) model assumes that a common set of unhelpful metacognitive beliefs have a central role in predisposition to psychological disorder and the maintenance of symptoms and distress. This research aims to test whether the five unhelpful metacognitive beliefs implicated in the m...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.10.029

    authors: Sellers R,Gawęda Ł,Wells A,Morrison AP

    更新日期:2016-12-30 00:00:00

  • Selective attrition does not affect cross-sectional estimates of associations with emotional and behavioral problems in a longitudinal study with onset in adolescence.

    abstract::The present examination raises the question whether attrition in a longitudinal study leads to biased findings. The Zurich Adolescent Psychology and Psychopathology Study (ZAPPS) originated in 1994 by following a sample of 1239 adolescents with follow-ups after three, six, and 22 years. The study collected data on lif...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2019.112685

    authors: Steinhausen HC,Spitz A,Aebi M,Metzke CW,Walitza S

    更新日期:2020-02-01 00:00:00

  • Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study.

    abstract::The subgenual prefrontal cortex (SGPFC) plays an important role in emotional processing. We carried out a magnetic resonance imaging (MRI) study comparing the volume of the SGPFC in child and adolescent bipolar patients and healthy controls. The sample consisted of 15 children and adolescents who met DSM-IV criteria f...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2004.11.004

    authors: Sanches M,Sassi RB,Axelson D,Nicoletti M,Brambilla P,Hatch JP,Keshavan MS,Ryan ND,Birmaher B,Soares JC

    更新日期:2005-01-30 00:00:00

  • Effects of season on electro-oculographic ratio in winter seasonal affective disorder.

    abstract::Low electro-oculographic (EOG) ratios have been reported in patients with seasonal affective disorder (SAD) during the winter. This study evaluated the effects of the changing seasons on EOG ratios in SAD patients. Sixteen outpatients with SAD and 16 age-, sex-, and medication-matched normal volunteers had EOG testing...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(95)02788-2

    authors: Ozaki N,Rosenthal NE,Myers F,Schwartz PJ,Oren DA

    更新日期:1995-11-29 00:00:00

  • Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study.

    abstract::The aim of the study was to describe diagnostic stability and psychosocial outcomes of subjects with early-onset schizophrenia (EOS). All the subjects who had been hospitalized in the Department of Psychiatry of the First Affiliated Hospital of Kunming Medical University between January 2011 and July 2015 with the dia...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.11.013

    authors: Kang C,Zhou H,Yang J,Yang R,Sun N,Wang S,Yang C,Han D,Srihari VH

    更新日期:2019-01-01 00:00:00

  • Serum prolactin levels following intramuscular chlorpromazine: two- and three-hour response as predictors of six-hour response.

    abstract::Neuroendocrine studies that examine the changes in serum prolactin levels following intramuscular (im) neuroleptics have usually monitored prolactin levels before and for 90 minutes to 3 hours after neuroleptic injection. Recent studies have suggested that this may be an inadequate period of time. In the present study...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(79)90056-8

    authors: Busch DA,Fang VS,Meltzer HY

    更新日期:1979-10-01 00:00:00

  • Psychometric properties of the positive and negative syndrome scale (PANSS) in schizophrenia.

    abstract::We analyzed the psychometric properties of the Positive and Negative Syndrome Scale (PANSS) in a sample of 100 DSM-III-R schizophrenic patients. Our findings coincided with the results of Kay's group in the following points: (1) the PANSS scores were normally distributed; (2) the positive and negative scales showed go...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(94)90093-0

    authors: Peralta V,Cuesta MJ

    更新日期:1994-07-01 00:00:00

  • Low-grade inflammation in first-episode psychosis is determined by increased waist circumference.

    abstract::Psychosis is associated with low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP), a risk factor for cardiovascular events and mortality in the general population. We investigated the relationship between hs-CRP and anthropometric and metabolic changes in first-episode psychosis (FEP) dur...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.10.022

    authors: Keinänen J,Suvisaari J,Reinikainen J,Kieseppä T,Lindgren M,Mäntylä T,Rikandi E,Sundvall J,Torniainen-Holm M,Mantere O

    更新日期:2018-12-01 00:00:00

  • Behavioral changes in patients with mild senile dementia of the Alzheimer's type.

    abstract::Behavioral changes in 44 subjects with well-characterized mild senile dementia of the Alzheimer's type (SDAT) and 16 subjects with only questionable SDAT were compared to a control group of 58 subjects. Answers to both open-ended questions and personality items from the Blessed Dementia Scale were examined. Seventeen ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(87)90062-x

    authors: Rubin EH,Morris JC,Storandt M,Berg L

    更新日期:1987-05-01 00:00:00

  • Towards a reliable repeated-measures beads task for assessing the jumping to conclusions bias.

    abstract::The jumping to conclusions bias (JTC), in which some people gather less information than others before making a decision, has been linked to delusions in psychosis. JTC is usually identified via the beads task, in which a sequence of beads (the "target" sequence) is used to measure the amount of evidence participants ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.04.043

    authors: McLean BF,Mattiske JK,Balzan RP

    更新日期:2018-07-01 00:00:00

  • Preliminary validation of a set of content analysis scales applicable to verbal samples for measuring the magnitude of psychological states in children.

    abstract::Scores on 17 psychological dimensions of the Gottschalk-Gleser content analysis scales were obtained from 5-minute speech samples of 37 white children hospitalized on the psychiatric service of a general hospital. These content analysis scores were compared to identical scores obtained from a normative sample of 109 w...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(79)90030-1

    authors: Gottschalk LA,Uliana RL,Hoigaard JC

    更新日期:1979-07-01 00:00:00

  • Role of REM sleep and dream variables in the prediction of remission from depression.

    abstract::To test the hypothesis that REM sleep and/or dreams contribute to overnight mood regulation, 61 subjects were tested on the Beck Depression Inventory (BDI), and for 3 nights of monitored sleep on two occasions, once close to, and 1 year after, a marital separation. Forty-nine percent of the variance in the follow-up B...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/s0165-1781(98)00071-7

    authors: Cartwright R,Young MA,Mercer P,Bears M

    更新日期:1998-09-21 00:00:00

  • Associations Between Subclinical Inflammatory Markers and OCD: A Retrospective Study.

    abstract::Obsessive-compulsive disorder (OCD) is characterized by unwanted, intrusive and disturbing thoughts or images that cause anxiety and repetitive behaviours or mental acts to relieve these thoughts or images. Considering controversial aetiology of OCD and growing evidence for the role of inflammation in OCD, the aim of ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2020.113065

    authors: Herdi O,Sayar-Akaslan D,İlhan RS,Çolak B,Duman B

    更新日期:2020-08-01 00:00:00

  • Decreased regional homogeneity in insula and cerebellum: a resting-state fMRI study in patients with major depression and subjects at high risk for major depression.

    abstract::Functional disconnectivity during the resting state has been observed in subjects with major depressive disorder (MDD), and in subjects at high genetic risk for major depression during task performance. It is hypothesized that functional impairments in certain brain areas are present in patients with MDD and in their ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2010.03.004

    authors: Liu Z,Xu C,Xu Y,Wang Y,Zhao B,Lv Y,Cao X,Zhang K,Du C

    更新日期:2010-06-30 00:00:00

  • Disclosure of mental illness to prospective employers: Clinical, psychosocial, and work correlates in persons receiving supported employment.

    abstract::Deciding whether to disclose one's psychiatric disorder to a prospective employer is a complex decision for people with severe mental illness seeking to return to work, with potential advantages and disadvantages. The present study examined the rates, patterns, and correlates of disclosure in 51 participants (74.5% sc...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2019.01.017

    authors: DeTore NR,Hintz K,Khare C,Mueser KT

    更新日期:2019-03-01 00:00:00

  • Gray matter density reduction in the insula in fire survivors with posttraumatic stress disorder: a voxel-based morphometric study.

    abstract::Voxel-based morphometry (VBM) is an objective whole-brain technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. In the current study, we used VBM to examine possible cerebral gray matter abnormalities in patients with posttraumatic stress di...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2005.09.006

    authors: Chen S,Xia W,Li L,Liu J,He Z,Zhang Z,Yan L,Zhang J,Hu D

    更新日期:2006-01-30 00:00:00