Abstract:
:New methods for using ketamine in patients with propofol-electroconvulsive therapy-resistant depression (ECT-RD) are needed in the clinic. This study aimed to investigate the therapeutic efficacy of ketamine plus ECT in ECT-RD patients, along with the treatment-induced brain alterations. A total of 28 ECT-RD patients were intravenously injected with ketamine six times and treated with propofol-ECT six times alternately within two weeks. The Hamilton Depression Scale was used to assess the treatment effect. Global functional connectivity density (gFCD) and functional connectivity strength (FCS) were used to evaluate functional brain alterations. As compared with the propofol-ECT treatment group, the addition of ketamine could improve the therapeutic outcomes in patients with ECT-RD. The treatment increased gFCD in the left temporal and subgenual anterior cingulated cortex. Simultaneously, the treatment decreased FCS within the default mode network. Although increased functional connectivity could be sustained for 10 days, the clinical effect was only sustained 7 days, indicating that the clinical effect and functional brain alterations were disjointed. Ketamine plus propofol-ECT can obviously improve the effects of propofol-ECT in ECT-RD patients. However, the effect is limited in 7 days, suggesting the benefit is short-term.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Zhang J,Tian H,Li J,Ji S,Chen S,Zhu J,Jiang D,Wang L,Li G,Chen M,Wang W,Lin X,Zhuo Cdoi
10.1016/j.psychres.2020.112907subject
Has Abstractpub_date
2020-05-01 00:00:00pages
112907eissn
0165-1781issn
1872-7123pii
S0165-1781(19)32442-4journal_volume
287pub_type
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