Abstract：
:Most investigators have measured binding of 3H-imipramine to platelet membranes, but some of the preparations may have contained varying proportions of intracellular protein because of contamination with incompletely lysed platelets. Since binding to membranes has been expressed with reference to the amount of protein in the membrane preparation, it is not surprising that there are discrepancies and a wide range of reported values for platelet imipramine binding in the literature. We have now completed a 9-month study of the binding of 3H-imipramine to intact platelets obtained monthly from 12 normal subjects. Using the intact platelet assay, as described by Friedl and Propping, we found that both Bmax and Kd for 3H-imipramine binding exhibited large month-to-month variations and no consistent seasonal trend was observed. The substantial variation in both Bmax and Kd among normal subjects and among samples obtained from the same individual at different times may limit the clinical usefulness of these measurements. A single blood sample is unlikely to give reliable values for Bmax and Kd for comparison purposes.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Goziotis A,Tang SWdoi
10.1016/0165-1781(88)90070-4subject
Has Abstractpub_date
1988-11-01 00:00:00pages
157-62issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(88)90070-4journal_volume
26pub_type
杂志文章abstract：:There is increasing evidence that obsessive-compulsive disorder (OCD) is mediated by genetic factors. Although the precise mechanism of inheritance is unclear, recent evidence has pointed towards the involvement of the serotonergic and dopaminergic systems in the disorder's development. Furthermore, early-onset OCD ap...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.05.007
更新日期：2004-09-30 00:00:00
abstract：:We investigated a 27-year old patient with paranoid schizophrenia. Brain activity related to visual hallucinations was found in higher visual areas corresponding to the content of the hallucinations (faces, bodies, scenes) and the hippocampus. We assume that the hippocampal activity is related to the retrieval of visu...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2007.09.004
更新日期：2007-12-15 00:00:00
abstract：:Body image disturbance and body dysmorphic disorder (BDD) have been researched from a variety of psychological approaches. Psychological inflexibility, or avoidance of one's own cognitive and affective states at a cost to personal values, may be a useful construct to understand these problems. In an effort to clarify ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.11.039
更新日期：2015-03-30 00:00:00
abstract：:Panic disorder (PD) is characterized by anticipatory anxiety and panic, both causing physiological arousal. We investigated the differential responses between anticipatory anxiety and panic in PD and healthy controls (HC). Subjects (15 PD and 30 HC) received an injection of a respiratory stimulant, doxapram, with a hi...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2015.03.001
更新日期：2015-05-30 00:00:00
abstract：:Individuals with body dysmorphic disorder (BDD) are preoccupied with perceived physical defects or flaws, often facial features, which may be due to distorted perception. Previous studies have demonstrated abnormalities in visual processing of faces and figures, and misinterpretations of emotional expressions. The obj...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.01.016
更新日期：2010-10-30 00:00:00
abstract：:This exploratory study aims to examine the differential effects of a computer-based cognitive training in 'prodromal' patients (mean age 27.20 years, S.D. 5.31 years) compared with patients with full-blown schizophrenia (mean age 30.13 years, S.D. 7.77 years). Ten patients at risk for schizophrenia and 16 patients suf...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2009.09.003
更新日期：2011-02-28 00:00:00
abstract：:It has been suggested that low frequency transcranial magnetic stimulation (TMS) over left temporo-parietal cortex may reduce the frequency and intensity of auditory hallucinations in schizophrenia. Sixteen patients with hallucinations, treatment-resistant for at least 2 months, were randomised into a placebo-controll...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.psychres.2004.03.005
更新日期：2004-06-30 00:00:00
abstract：:Psychiatric neuroimaging techniques are likely to improve understanding of the brain in health and disease, but studies tend to be small, based in one imaging centre and of unclear generalisability. Multicentre studies have great appeal but face problems if functional magnetic resonance imaging (fMRI) data from differ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.08.010
更新日期：2010-11-30 00:00:00
abstract：:Chronic imipramine administration decreases the density of serotonin S2 and beta-adrenergic receptors. The mode of action is not clear but might be assumed to be a result of imipramine interacting with its high affinity binding sites on presynaptic serotonin neurons. To investigate this possibility and the role of the...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(83)90045-8
更新日期：1983-07-01 00:00:00
abstract：:We investigated a combination of three classification algorithms, namely the modified maximum uncertainty linear discriminant analysis (mMLDA), the centroid method, and the average linkage, with three types of features extracted from three-dimensional T1-weighted magnetic resonance (MR) brain images, specifically MR i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.03.004
更新日期：2015-06-30 00:00:00
abstract：:Conventional bedside tests of visuospatial function such as the Clock Drawing (CDT) and Intersecting Pentagons (IPT) lack consistency in delivery and interpretation. We compared performance on a novel test of visuospatial ability - the LSD - with the IPT, CDT and MMSE in 180 acute elderly medical inpatients [mean age ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.12.004
更新日期：2017-01-01 00:00:00
abstract：:Cannabis use has been associated with a continuum of psychotic experiences. However, it is unclear whether mood and anxiety symptoms account for increases in attenuated positive psychotic symptoms (APPS) among cannabis users. We predicted that depression and anxiety symptoms would mediate the relation between cannabis...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.03.040
更新日期：2014-08-15 00:00:00
abstract：:This study investigated whether the indices of dopaminergic function, yawning and growth hormone release induced by apomorphine, as well as the drug-induced nausea and hyperthermia, show sensitization or tolerance to repeated injections. Five normal volunteers received 12 injections of apomorphine hydrochloride (0.75 ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90015-7
更新日期：1988-03-01 00:00:00
abstract：:Recent studies have suggested an increased risk of psoriasis among patients with schizophrenia although the results are still inconclusive. This systematic review and meta-analysis of cohort and case-control studies that compared the risk psoriasis among patients with schizophrenia versus subjects without schizophreni...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.psychres.2017.11.021
更新日期：2018-01-01 00:00:00
abstract：:Exposure to smoking cues increases craving to smoke and negatively changes mood in smokers with schizophrenia (SWS). This pilot study compared reactivity to real-world smoking environments versus neutral environments in SWS (n=10) and non-psychiatric control smokers (CON; n=10). Results indicate that both SWS and CON ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.04.005
更新日期：2011-07-30 00:00:00
abstract：:Increasing evidence implicates altered dopamine function in major affective illness. In the present study, growth hormone responses to the dopamine agonist apomorphine were not different for 14 male depressed patients and 16 healthy male volunteers. Baseline and post-apomorphine prolactin levels were lower for the dep...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90113-6
更新日期：1984-09-01 00:00:00
abstract：:Eating disorders (EDs) remain understudied among veterans, possibly due to the perception that primarily male population does not suffer from EDs. However, previous research suggests that male and female veterans do experience EDs. The high rates of posttraumatic stress disorder (PTSD), depression, and obesity observe...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.06.018
更新日期：2014-11-30 00:00:00
abstract：:Seventeen obsessive-compulsive disorder (OCD) patients and 25 normal control subjects submitted 24-hour urine samples for measurement of urinary free cortisol (UFC). Thirteen of the 17 OCD patients submitted a second 24-hour urine collection after a 10-week trial of either clomipramine (n = 6) or placebo (n = 7). At b...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90081-f
更新日期：1990-05-01 00:00:00
abstract：:Heightened emotional reactivity is one of the core features of borderline personality disorder (BPD). However, recent findings could not provide evidence for a general emotional hyper-reactivity in BPD. The present study examines the emotional responding to self-relevant pictures in dependency of the thematic category...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2014.06.041
更新日期：2014-12-15 00:00:00
abstract：:In the present study we set out to explore the long-term clinical course of schizophrenia in a holistic manner by adopting sequence analysis. Our aim was to identify course types of illness by means of cluster analysis. The study was based on course and outcome data for 107 patients followed up over 134 months after f...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.04.056
更新日期：2015-08-30 00:00:00
abstract：:Depression is associated with a lowered degree of esterification of serum cholesterol, an increased C20:4omega6/C20:5omega3 ratio and decreases in omega3 fractions in fatty acids (FAs) or in the red blood cell membrane. The aims of the present study were to examine: (i) serum phospholipid and cholesteryl ester composi...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/s0165-1781(99)00014-1
更新日期：1999-03-22 00:00:00
abstract：:As a psychiatric treatment, modern electroconvulsive therapy (ECT) requires anesthesia to enhance safety, but anesthetics may weaken its efficacy. Previous studies have provided inconsistent results and lack satisfactory details of the influence of anesthetics on ECT efficacy, which partially complicates the clinical ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.09.010
更新日期：2012-07-30 00:00:00
abstract：:Voxel-based morphometry and functional magnetic resonance imaging demonstrated severe atrophy and decreased activation of visual attention areas and occipital lobes in a patient with early posterior cortical atrophy compared with healthy controls and patients with early Alzheimer's disease. Our complex approach indica...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2008.01.006
更新日期：2008-11-30 00:00:00
abstract：:This case highlights recurrent low-grade fevers caused by extended-release Quetiapine (Quetiapine XR), a previously unreported side effect, in a patient with Schizophreniform Disorder. While there have been case reports of Quetiapine causing neuroleptic malignant syndrome, there is paucity of data specifically describ...
journal_title：Psychiatry research
pub_type： 信件
doi：10.1016/j.psychres.2020.113583
更新日期：2021-01-01 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder characterized by intrusive thoughts and behaviors that dominate daily living, like an itch patients cannot ignore. Deficits in executive functioning are common in OCD and are thought to be related to dysfunctional frontal-striatal systems....
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.12.006
更新日期：2013-07-30 00:00:00
abstract：:There is evidence from research based on self-report personality measures that schizophrenia patients tend to be lower in extraversion and higher in neuroticism than healthy individuals. Self-report personality measures assess aspects of the explicit self-concept. The Implicit Association Test (IAT) has been developed...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.023
更新日期：2014-08-30 00:00:00
abstract：:Previous studies that operationalized reactive aggression using behavioral observations in general populations have not taken into account the type of stimulus that elicits reactive aggression. In the present study we define a specific form of reactive aggression, i.e., reactive aggression in response to neutral behav...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.08.006
更新日期：2010-04-30 00:00:00
abstract：:The antipsychotic effects of dopamine D2 receptor antagonists (neuroleptics) and the psychotomimetic effects of dopamine agonists suggest that a defect of the D2 receptor gene might be a factor in the etiology of schizophrenia. Fifteen families that contained several members suffering from schizophrenia were tested fo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90111-2
更新日期：1994-08-01 00:00:00
abstract：:Recent clinical studies report antipsychotics as a better option to augment the action of antidepressants in treatment resistant cases. However, the proper mechanisms underlying the antidepressant effect of antipsychotics is still not clear. Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.083
更新日期：2017-12-01 00:00:00
abstract：:Earlier neuroimaging studies of working memory (WM) have demonstrated that dorsolateral prefrontal cortex (DLPFC) activity increases as maintenance and load demand increases. However, few studies have carefully disambiguated these two WM processes at the behavioral and physiological levels. The objective of the presen...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.08.002
更新日期：2007-02-28 00:00:00
