Abstract:
:Conventional bedside tests of visuospatial function such as the Clock Drawing (CDT) and Intersecting Pentagons (IPT) lack consistency in delivery and interpretation. We compared performance on a novel test of visuospatial ability - the LSD - with the IPT, CDT and MMSE in 180 acute elderly medical inpatients [mean age 79.7±7.1 (range 62-96); 91 females (50.6%)]. 124 (69%) scored ≤23 on the MMSE; 60 with mild (score 18-23) and 64 with severe (score ≤17) impairment. 78 (43%) scored ≥6 on the CDT, while for the IPT, 87 (47%) scored ≥4. The CDT and IPT agreed on the classification of 138 patients (77%) with modest-strong agreement with the MMSE categories. Correlation between the LSD and visuospatial tests was high. A four-item version of the LSD incorporating items 1,10,12,15 had high correlation with the LSD-15 and strong association with MMSE categories. The LSD-4 provides a brief and easily interpreted bedside test of visuospatial function that has high coverage of elderly patients with neurocognitive impairment, good agreement with conventional tests of visuospatial ability and favourable ability to identify significant cognitive impairment. [181 words].
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Williams OA,O'Connell H,Leonard M,Awan F,White D,McKenna F,Hannigan A,Cullen W,Exton C,Enudi W,Dunne C,Adamis D,Meagher Ddoi
10.1016/j.psychres.2016.12.004subject
Has Abstractpub_date
2017-01-01 00:00:00pages
317-322eissn
0165-1781issn
1872-7123pii
S0165-1781(16)30115-9journal_volume
247pub_type
杂志文章abstract::Evidence on mental illness stigma abounds yet little is known about public perceptions of intellectual disability. This study examined causal beliefs about intellectual disability and schizophrenia and how these relate to awareness of the condition and social distance. UK lay people aged 16+(N=1752), in response to vi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.06.019
更新日期:2016-09-30 00:00:00
abstract::A central program for recruiting "normal" control subjects is examined by considering the yield of subjects who meet criteria for "healthy" as defined by their personal and family histories of mental disorders. Of the 267 applicants, 30.3% have no lifetime diagnoses, 41.2% are currently healthy with a history of menta...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(94)90057-4
更新日期:1994-09-01 00:00:00
abstract::The immense burden of health conditions in children that is associated with mental disorders worldwide is increasingly being recognized. In comparison, the burden of disability associated with children's impairments of psychological functions (IPFs) is not well documented. The goal of this population-based study was t...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2010.03.001
更新日期:2010-05-15 00:00:00
abstract::This study describes the Brief Inventory of Social Support Exchange Network (BISSEN) as a standardized brief inventory measuring various aspects of social support. We confirmed the reliability and validity for function and direction of support and standardized the BISSEN. For Sample 1, a stratified random sampling met...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.03.056
更新日期:2017-07-01 00:00:00
abstract::The activity of phosphatidylinositol-specific phospholipase C was significantly reduced in platelets obtained from 20 euthymic manic-depressive patients on therapeutic lithium doses (mean blood level 0.85 mEq/l) compared to an age- and sex-matched group of 36 control subjects. The activities of prostaglandin E1-, alum...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(88)90138-2
更新日期:1988-04-01 00:00:00
abstract::Previous work suggests that iomazenil (formerly known as Ro 16-0154) is a useful ligand for static imaging of the benzodiazepine (BZ) receptor with single photon emission computed tomography (SPECT). The present study evaluated the feasibility of dynamic SPECT imaging of cerebral radioactivity following intravenous [1...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(92)90001-k
更新日期:1992-08-01 00:00:00
abstract::This study examined care pathways, program engagement, and key outcomes associated with a sub-acute inpatient stay in a 20-bed stand-alone Intermediate Stay Mental Health Unit (ISMHU; NSW, Australia). A 6-week evidenced-based tailored intervention program was offered, utilizing a recovery-oriented model of care. Servi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.112889
更新日期:2020-02-20 00:00:00
abstract::The relationship between levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) and symptom scores on the Hamilton Rating Scale for Depression was examined in 31 patients with unipolar depression. Patients with either low MHPG or high MHPG showed significant sleep disturbance in the form of early morning awakening. ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(94)90035-3
更新日期:1994-02-01 00:00:00
abstract::Differences in antipsychotic treatment response, clinical course and outcome of schizophrenia could be related to gender-related cerebral differences in anatomy and function. The aim of the study was to assess sex differences in the striatal dopamine D2 receptor binding in 15 drug-naive schizophrenic patients (seven m...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2003.05.001
更新日期:2004-01-15 00:00:00
abstract::Ten patients with severe, therapy-resistant manic agitation received magnesium sulphate infusions with a continuous magnesium (Mg) flow of approximately 200 mg/h (4353+/-836 mg/day; daily monitored Mg plasma level: 2.44+/-0.34 mmol/l) for periods ranging from 7 to 23 days. Concomitant psychotropic treatment consisted ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(99)00107-9
更新日期:1999-12-27 00:00:00
abstract::The aim of this study was to assess social- perceptual Theory of Mind in bipolar disorder (BD). 112 euthymic participants with BD I or BD II (65 with BD I and 47 with BD II) were compared to a group of 112 persons with no psychiatric diagnosis and 43 with unipolar depression (UD). They completed the task of the "Readi...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.09.039
更新日期:2018-04-01 00:00:00
abstract::This study examined the Montreal Cognitive Assessment (MoCA) as a neurocognitive screener and its relationship with functional outcomes in a sample of outpatients diagnosed with severe mental illness (SMI). The MoCA, Brief Assessment of Cognition in Schizophrenia (BACS), UCSD Performance-Based Skills Assessment Test-2...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.07.078
更新日期:2014-12-15 00:00:00
abstract::Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder in which, classically, patients present with postural instability and falls, parkinsonism, and slowing of vertical saccades. PSP patients typically have deficits in cognitive functioning, difficulties with most daily activities, and present with...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.08.045
更新日期:2013-12-30 00:00:00
abstract::The experience of maternal distress in pregnancy is often linked with poorer obstetric outcomes for women as well as adverse outcomes for offspring. Alterations in placental glucocorticoid signalling and subsequent increased fetal exposure to cortisol have been suggested to underlie this relationship. In the current s...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2017.05.013
更新日期:2017-09-01 00:00:00
abstract::Reduction of volume and neuronal number has been found in several association nuclei of the thalamus in schizophrenic subjects. Recent evidence suggests that schizophrenic patients exhibit abnormalities in early visual processing and that many of the observed perceptual deficits are consistent with dysfunction of the ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2006.11.003
更新日期:2007-05-30 00:00:00
abstract::A key characteristic of bipolar disorder is fluctuation in mood symptoms and functional capacity, yet assessment of bipolar symptomatology often relies heavily on interval measurement that is unable to capture the full range of daily symptom variability and severity. The current study provides a detailed analysis of t...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.04.047
更新日期:2014-08-30 00:00:00
abstract::In an attempt to clarify the possible role of a serotonergic and dopaminergic dysfunction in obsessive-compulsive disorder (OCD), we measured platelet 3H-imipramine (3H-IMI) binding, serotonin uptake, and platelet sulfotransferase activity in 17 drug-free OCD patients and an equal number of healthy controls. Serotonin...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(92)90037-4
更新日期:1992-04-01 00:00:00
abstract::In people with schizophrenia several factors are associated with poor quality of life (QoL), namely, lifestyle-related factors and psychological factors. However, there has been little research on the impact of these factors on QoL. Therefore, the relation between lifestyle-related factors, psychological factors, and ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.06.022
更新日期:2018-09-01 00:00:00
abstract::Correlations between normalized regional cerebral metabolic rates for glucose, determined by positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose, were used to investigate functional associations between pairs of brain regions in 18 adult patients with primary obsessive-compulsive disorder (OCD) of childho...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0925-4927(91)90014-h
更新日期:1991-12-01 00:00:00
abstract::Knowledge of how specific neurocognition (NC) abilities predict social cognition (SC) in schizophrenia has potential to guide novel integrated cognitive-remediation therapies. The scope of studies conducted in this field is limited as they have not examined a comprehensive set of SC domains and they employ small sampl...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.05.055
更新日期:2014-10-30 00:00:00
abstract::Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for de...
journal_title:Psychiatry research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.psychres.2016.11.014
更新日期:2017-01-01 00:00:00
abstract::The PHQ-9 has been found to be reliable and valid, but with both a single and two-factor structure suggested in the literature. This measure has not yet been subject to psychometric investigation using Mokken scale analysis. Confirmatory Factor Analysis (CFA) and Mokken analysis were performed on retrospective data fr...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.12.048
更新日期:2019-01-01 00:00:00
abstract::Birth in late winter and spring has been consistently shown to be a risk factor of schizophrenia. The relationship of late winter/spring birth to clinical characteristics and other putative risk factors, such as family history and obstetric complications, may provide clues to etiology. Data relating to season of birth...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(96)02868-5
更新日期:1996-08-30 00:00:00
abstract::Rises in unemployment as a corollary to the global economic crisis may impinge on the prevalence of depression disproportionally for the two genders. Therefore, differences in the prevalence of the disorder as a function of gender and age were explored in four nationwide surveys in Greece in 2008, 2009, 2011 and 2013....
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.05.041
更新日期:2016-08-30 00:00:00
abstract::Joint effects of genotype and the environment have turned out to be significant in the development of psychotic disorders. The purpose of the present study was to assess the association of an adoptive child׳s thought and schizophrenia spectrum disorders with genetic and environmental risk indicators and their interact...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.12.036
更新日期:2015-04-30 00:00:00
abstract::The World Health Organization ranks obsessive compulsive disorder (OCD) among the leading causes of worldwide medical disability. Affecting approximately 3% of the population, OCD, with its damaging effect on psychosocial function, is among the most severe and impairing of mental disorders. In Diagnostic and Statistic...
journal_title:Psychiatry research
pub_type:
doi:10.1016/j.psychres.2014.12.002
更新日期:2015-05-30 00:00:00
abstract::The goal of this study was to assess integrity of the cingulum bundle in patients diagnosed with first episode schizophrenia, chronic schizophrenia, and matched controls as well as to determine the relationship between diffusion measures of cingulum bundle integrity and severity of patients' delusions of reference. Pa...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2014.08.002
更新日期:2014-11-30 00:00:00
abstract::Negative symptoms have been suggested to have a greater impact on real-world functioning in schizophrenia than other symptoms. We aimed to examine the relationship of specific negative symptoms components ("expressive deficits" - DE - which include alogia and blunted affect, and "avolition" - AA - which includes amoti...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.04.018
更新日期:2014-08-30 00:00:00
abstract::The seven-factor model of personality developed by Cloninger and colleagues describes personality as a function of developmental aspects of character superimposed on heritable dimensions of temperament. The objective of this study was to determine whether this model could be applied to early childhood. We tested a pre...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(02)00008-2
更新日期:2002-04-15 00:00:00
abstract::Co-existence of Asperger syndrome (AS) and non-verbal learning disability (NLD) has been proposed based on the observation that people with AS tend to have significantly higher verbal than performance IQ (VIQ > PIQ by ≥ 15 points), one of the core features of NLD. In the present study we examined neuropsychological an...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.06.006
更新日期:2013-12-15 00:00:00